Bone Abstracts

Background and objective: High-resolution magnetic resonance imaging (hrMRI) can assess trabecular bone microarchitecture but the number of image slices required for reliable assessment is unclear.Methods: MRI was performed just below the growth plate of the proximal tibia from 20 healthy controls (all female; median age 21 years (range 18–35) and 10 cases (three mals: seven females; median age 19.5 years (range 16–48) with known bone abnormali...

The aim of this study was to estimate the structure of pain syndrome and reveal the presence of neuropathic pain component in patients suffering from the osteoporosis and low back pain.Material and methods: We have examined 107 patients aged 45–89 years (average age 68.1±1.2 years). Patients were divided into 2 groups: A – patients with osteoporosis (n=49), B – patients with low back pain (n=58). And according to age...

Objective: Children in rural areas have inadequate nutritional intake, hence their muscle function may be compromised. The objective of this study was to study the determinants of muscle function in rural Indian school going children.Methods: We cross sectionally studied 232 prepubertal school going children (106 girls) aged 6–11 years, from 2 different villages in rural area around Pune city in July 2018. Height, weight, body composition (bioelectr...

There is increasing evidence for the key role of osteocytes in the regulation of bone remodeling. One of the main products of these cells, sclerostin, inhibits bone formation and may also stimulate bone resorption. To our knowledge, there are few data in prostate cancer (PC) patients especially in patients with hypogonadism related to androgen deprivation therapy (ADT). The aim of this study was to compare serum levels of sclerostin in ADT-treated and untreated PC patients wit...

Introduction: The FRAX model is a new method to assess fracture risk and this aspect is important in menopause. The DXA is still the golden standard but the relationship between these two instruments is complex.Aim: We correlate the 10-year absolute fracture risk of hip (10-yH) and major fractures (10-yM) based on FRAX with or without bone mineral density (BMD) with lumbar DXA in menopause women, and we use a statistical model to find out whether the vit...

Background: Previous TBS studies in type 2 diabetes have suggested a deterioration of bone microarquitecture that could be related to a higher risk of fractures. However, there are no information in liver transplantation (LT) patients with new-onset diabetes after transplantation (NODAT).Our aim was to investigate TBS in LT patients and the influence of NODAT in these patients. Also, we investigated the relationship between TBS and body composition param...

Introduction: The creatine kinase (CK) is a dimeric enzyme, involved in energetical metabolism. It is present in many tissues, but higher concentration in skeletal and cardiac muscle.Therefore, conditions that involve muscle tissue may increase this serum enzyme. Such enzyme elevation is usually observed in inflammatory myopathies and others autoimmune diseases.Sometimes some elevation in CK is not fully understood out off these co...

Sclerostin is a major negative regulator of osteoblastic activity. Serum sclerostin has a weak positive association with BMD but contradictory results have been described concerning associations with fractures. These contradictions could be explained by the fact that serum sclerostin does not reflect its action in bone. In this study we question whether serum sclerostin is associated with its expression in bone. In addition we aimed to detect associations between sclerostin in...

Objectives: Evaluation of influence the structural and functional condition of bone tissue on caries intensity in adolescents living with deficient of fluoride in drinking water (<0.4 mg/l).Methods: It was examined 200 school children (12 and 15 years old) living in Transcarpathian region.Oral examination was done to determine caries intensity in the subjects (DMFT-index). Bone quality was determined using quantitative ultrasou...

Objective: To study any possible relations of vitamin D status and metabolic syndrome (MetS) components in children, since there is evidence for extraskeletal functions of vitamin D, and its deficiency may contribute to the pathogenesis of several major diseases. In addition to explore any possible role of birth weight (BW).Methods: Clinically healthy children aged 3–9 years (n=152) were included in the study. Forty-six were born large for ...