Bone Abstracts

Abstract: Osteogenesis imperfecta, also known as ‘brittle bone disease’, is a heterogeneous disorder of connective tissue generally caused by dominant mutations in the genes COL1A1 and COL1A2, encoding the α1 and α2 chains of type I (pro)collagen. Symptomatic patients are usually prescribed bisphosphonates, but this treatment is neither curative nor sufficient. A promising field is gene silencing through RNA interference. In this study, small interfering RN...

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In type 2 diabetes mellitus (T2DM) patients, an increased fracture risk is observed, although the bone mineral density is even higher than in non-diabetic patients. This raises the question of the quality of the organic and inorganic matrix in bone1–3. T2DM is also known to forward dysfunctions in the development of soft tissues such as brittle skin due to cross-linking of the collagen or inflammation of the gingiva. For the latter, a possible influence of diab...

Objectives: To investigate the burden and impact of gastrointestinal (GI) events in osteoporosis (OP) patients by i) examining the association of GI events with the likelihood of OP treatment initiation; ii) measuring the effect of GI events on treatment discontinuation; and iii) determining the impact of GI events post-OP treatment on health care resource utilization and cost. All subjects are identified utilizing national health registries which cover the whole Danish popula...

We previously demonstrated that an isocaloric low protein diet attenuates the bone anabolic response to GH. Whether such a dietary manipulation could affect the bone anabolic effects of PTH was assessed. We studied 6-month-old female rats pair fed with isocaloric diets with a low protein (2.5% casein, LP) or normal protein content (15% casein, NP) for 2 weeks. Then, the animals were treated with 5 or 40 μg/kg recombinant human amino-terminal fragment PTH(1–34) (PTH-5...

Introduction: Biopsy is a milestone in the diagnosis and treatment of skeletal lesions. Closed core-needle biopsy under computed tomography (CT) guidance is the gold standard. Open biopsy on the other hand may lead to more secure diagnosis.Objectives: Aim of this retrospective case-series study was the review of all biopsies (closed and open) performed at our department during the last eleven years in children suffering from bone tumours and the evaluati...

Spatial distributions of major and minor chemical elements are supposed to change during tissue maturation and due to bone diseases. Previous studies suggested that osteocytes have the ability to interact with the bone matrix of their environment. For this interaction osteocytes make use of the big inner surface of the osteocyte lacuno-canalicular network (OLCN) in which they are accommodated. The aim of this study was to quantify spatial correlations between the elemental com...

Increasing bone formation is an effective approach to prevent osteoporotic fractures. Although the intermittent administration of PTH is an established osteoanabolic therapy and an anti-Sclerostin antibody (Scle-AB) is currently being tested in phase 3 clinical trials, a great need exists for additional bone anabolic agents. Thus, in the context of a bi-national consortium we aim to uncover novel epigenomic networks controlling bone formation to identify new epigenomic approac...

Objective: To assess the effect of mechanical loading in anorexia nervosa (AN) in vivo, by comparing bone geometry and microarchitecture in weight bearing versus non-weight bearing bone.Subjects and methods: A total of 26 female patients with AN, and 26 female controls matched on age and height were included. Bone geometry, volumetric bone mineral density (vBMD) and microarchitecture were assessed using HR-pQCT (Scanco Medical, Brütisellen,...

Purpose: Denosumab is commonly used as an anti-resorptive agent to treat osteoporosis. After discontinuation of denosumab, however, bone resorption increases again, and the bone mass gained during therapy is lost within a year.Methods: We present a case report of asymptomatic hypoparathyroid hypercalcemia in a patient who discontinued long-term treatment with denosumab.Results: A 67-year old women with osteoporosis was treated with...