Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

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ba0005op19 | Clinical (1) | ECTS2016

Profiles of 25 hydroxyvitamin D and its metabolites 24, 25-dihydroxyvitamin D and 1, 25-dihydroxyvitamin D in vitamin D3 supplementation studies

Tang Jonathan , Nicholls Holly , Dutton John , Piec Isabelle , Washbourne Christopher , Saleh L , Novak A , Close G , Macdonald H , Jackson S , Greeves J , Fraser William

see P21....
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ba0005p21 | Biochemical testing | ECTS2016

Profiles of 25 hydroxyvitamin D and its metabolites 24, 25-dihydroxyvitamin D and 1, 25-dihydroxyvitamin D in vitamin D3 supplementation studies

Tang Jonathan , Nicholls Holly , Dutton John , Piec Isabelle , Washbourne Christopher , Saleh L , Novak A , Close G , Macdonald H , Jackson S , Greeves J , Fraser William

Background: Vitamin D plays an important role in calcium and phosphate homeostasis. Circulating 25 hydroxyvitamin D [25(OH)D] is metabolised into its biologically active form 1,25-dihydroxyvitamin D [1,25-d(OH)D] by the actions of 1α hydroxylase, and into inactive 2metabolite 24,25-dihydroxyvitamin D [24,25-d(OH)D] by 24-hydroxylase. Recent studies suggest the production of 1,25-d(OH)D) from 25(OH)D is 24,25-d(OH)D dependent. Genetic mutations of CYP24A1 gene resulting in...
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ba0005p372 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Sex hormone-binding globulin is associated with markers of vertebral fracture and vertebral fracture risk

Koromani Fjorda , Muka Taulant , Oei Ling , Zillikens Carola , Hofman Albert , Uitterlinden Andre G , Oei Edwin , Hans Didier , Franco Oscar H , Rivadeneira Fernando

Background: The relation between sex hormone-binding globulin (SHBG) and vertebral fracture (VFx) is unclear.Aim: To examine whether SHBG is associated with bone mineral density at lumbar spine (LS-BMD), trabecular bone score (TBS) and prevalent VFx.Methods: Data of 6224 men and women participants in the third visit of the first cohort (I-3) and the first visit of the second cohort (II-1) of a prospective population based cohort, w...
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ba0005p373 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

The association between diabetes, trabecular bone score, bone mineral density and vertebral fractures

Koromani Fjorda , Muka Taulant , Oei Ling , Zillikens Carola , Hofman Albert , Franco Oscar H , Uitterlinden Andre G , Oei Edwin , Hans Didier , Rivadeneira Fernando

Background: Fracture risk is increased in Type 2 diabetes (T2D) individuals. Bone mineral density (BMD) is inversely associated with fracture risk but paradoxically high in T2D individuals. Trabecular bone score (TBS) reflects bone microarchitecture and predicts fracture risk.Objective: We aimed to compare mean lumbar spine TBS (LS-TBS) and lumbar spine BMD (LS-BMD) values, across individuals with and without i) vertebral fracture (VFx), ii) T2D; and iii...
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ba0002oc10 | Biology | ICCBH2013

Phenotypic dissection of bone mineral density facilitates the identification of skeletal site specificity on the genetic regulation of bone

Kemp John P , Medina-Gomez Carolina , Estrada Karol , Heppe Denise H M , Zillikens Carola M , Timpson Nicholas J , St Pourcain Beate , Ring Susan M , Hofman Albert , Jaddoe Vincent W V , Smith George Davey , Uitterlinden Andre G , Tobias Jonathan H , Rivadeneira Fernando , Evans David M

Heritability of bone mineral density (BMD) varies at skeletal sites, possibly reflecting different relative contributions of environmental and genetic influences. To quantify shared genetic influences across different sites, we estimated the genetic correlation of BMD at the upper limb (UL), lower limb (LL) and skull (S) obtained from whole body DXA scans, using bivariate genome-wide complex trait analysis (GCTA). The study (n=9395) combined data from the Avon Longitu...
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ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...
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ba0002p102 | (1) | ICCBH2013

Influence of nutritional status in the bone mass assessed by quantitative ultrasonography of boys

de Oliveira Barbeta Vinicius Justino , Bertapelli Fabio , Goncalves Ezequiel Moreira , Krahenbuhl Tathyane , de Barros Ramalho Luiz Carlos , Martin Juan Eduardo Samur-San , Ribeiro Roberto Regis , Guerra-Junior Gil

The childhood is an important period for bone mass acquisition, and this tissue may be influenced by the nutritional status. However, the relation between the nutritional status and the bone parameters of quantitative ultrasound (QUS) remains unclear. The aim of this study was to verify the influence of nutritional status on bone mass assessed by QUS in male children from 7 to 10 years old. The sample consisted of 461 Brazilians pre-pubertal schoolchildren (8.30±1.13 year...
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ba0001pp126 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2013

Vitamin D: light side and best time of sunshine in Riyadh, Saudi Arabia

Alshahrani Fahad , Almalki Mussa , Aljohani Naji , Alzahrani Abdullah , Alsaleh Yossef , Holick Michel

Low levels of 25-hydroxyvitamin D have been documented among inhabitants of the wider Middle East and North African countries. Sunlight has long been recognized as a major provider of vitamin D. In this study we aimed to determine the optimum time for sun exposure in the Central region of Riyadh, Saudi Arabia. Ampoules containing 7-dehydrocholesterol in ethanol were exposed to sunlight every hour starting from sunrise until sunset in July and December. Our results demonstrated...
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ba0001ni7 | (1) | ECTS2013

Phenotypic dissection of bone mineral density facilitates the identification of skeletal site specificity on the genetic regulation of bone

Kemp John P , Medina-Gomez Carolina , Estrada Karol , Heppe Denise , Zillikens Carola , Timpson Nicholas , Pourcain Beate , Ring Susan , Hofman Albert , Jaddoe Vincent V W , Smith George Davey , Uitterlinden Andre G , Tobias Jonathan H , Rivadeneira Fernando , Evans David M

see PP282....
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ba0001pp282 | Genetics | ECTS2013

Phenotypic dissection of bone mineral density facilitates the identification of skeletal site specificity on the genetic regulation of bone

Kemp John P , Medina-Gomez Carolina , Estrada Karol , Heppe Denise , Zillikens Carola , Timpson Nicholas , Pourcain Beate , Ring Susan , Hofman Albert , Jaddoe Vincent V W , Smith George Davey , Uitterlinden Andre G , Tobias Jonathan H , Rivadeneira Fernando , Evans David M

Heritability of bone mineral density (BMD) varies at skeletal sites, possibly reflecting different relative contributions of environmental and genetic influences. To quantify shared genetic influences across different sites, we estimated the genetic correlation of BMD at the upper limb (UL), lower limb (LL), and skull (S) obtained from whole body DXA scans, using bivariate genome-wide complex trait analysis (GCTA). The study (n=9395) combined data from the Avon Longit...
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Bone Abstracts
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