Searchable abstracts of presentations at key conferences on calcified tissues

ba0004oc17 | (1) | ICCBH2015

Inhibition of TGFβ signalling delays ossification in patients with fibrodysplasia ossificans progressiva

Micha Dimitra , Voermans Elise , Huib van Essen , Drukker Jesse , Netelenbos Coen , Eekhoff Marelise , Bravenboer Nathalie

Fibrodysplasia ossificans progressiva (FOP) is a rare congenital disorder characterized by progressive heterotopic ossification. FOP patients only present great toe malformations at birth. However, as they grow older they develop soft tissue lumps as a result of flare-ups causing the irreversible replacement of skeletal muscle tissue with bone tissue leading to cumulative physical immobility. Classical FOP patients possess a mutation (c.617G>A; R206H) in the activin recept...

ba0004p10 | (1) | ICCBH2015

Infantile Blount's disease: histopathologic changes in the proximal tibial metaphysis -- comparison between medial and lateral specimens

Hollman Freek , Vroemen Pascal , Rompa Paul , Moh Prosper , van Rhijn Lodewijk , Weltink Tim , Staal Heleen

Only minor literature on histopathologic changes in Blount’s disease is available. This study presents the histologic findings of biopsies harvested from the medial and lateral part of the proximal tibia during the W/M serrated osteotomy in patients with infantile Blount’s disease, performed in Ghana. In this study it is hypothesized that the medial metaphyseal area in these children will present a different histological morphology compared to the lateral metaphyseal...

ba0004p30 | (1) | ICCBH2015

Whole-body MR imaging as diagnostic tool in children with hereditary multiple osteochondromas

Staal Heleen , Dremmen Marjolein , Robben Simon , Witlox Adhiambo , van Rhijn Lodewijk

Patients with hereditary multiple osteochondromas (HMO) undergo frequent X-rays to evaluate the growth of the osteochondromas. The conventional radiographs show clear images of the growth of the bony part of the osteochondromas and of the growth direction of the long bones. However the cartilage cap on the osteochondroma nor the cartilage of the nearby epiphysis or the surrounding soft tissue of the osteochondromas is shown. Besides these disadvantages taking frequent radiogra...

ba0005cabs.oc2.1 | Oral Communications | ECTS2016

Prostate cancer microRNAs in extracellular vesicles stimulate osteoclastogenesis

Bijnsdorp Irene , Mulder Jorn , Geldof Albert , Bakker Astrid , de Vries Teun , van Moorselaar Jeroen

Prostate cancer (PCa) is the most common cancer in males. When patients develop metastasis, no curative therapy is available. To find new therapeutic options, it is crucial to understand how PCa cells induce metastasis. Recently, it was shown that PCa cells secrete small extracellular vesicles (EVs) that can be found in the circulation and in bones. Uptake of EVs by other cells may change their behaviour. We previously identified three miRNAs that were uniquely upregulated in ...

ba0005p318 | Osteoporosis: evaluation and imaging | ECTS2016

Circulating microRNA in metabolic bone diseases-osteoporosis

Mandourah Abdullah , Hof Rob Van' T , Ranganath Lakshminarayan , Barraclough Roger , Barraclough Dong

Osteoporosis is the commonest worldwide age-related bone disease. It is clinically symptomless until the first fracture happens. Circulating microRNAs can be used as novel biomarkers to assess health status and progression of complex diseases. A recent review highlighted the involvement of microRNAs in the control of bone formation and remodeling. Most of these studies have been done on animal models, but few on human blood samples.This research aims to ...

ba0005p463 | Other diseases of bone and mineral metabolism | ECTS2016

Change in bone mineral density with high-dose prednisone in patients with rheumatoid arthritis

Rasch Linda , van Tuyl Lilian , Kremer Martijn , Bultink Irene , Boers Maarten , Lems Willem

Background: Recently, we showed that treatment with COBRA-light therapy including prednisone with initially 30 mg/day was as effective as the original COBRA scheme, with initially 60 mg/day (Ter Wee, ARD 2015), in the treatment of rheumatoid arthritis (RA). Since high-dose glucocorticoids are associated with bone loss, we investigated the differences in bone mineral density (BMD) after 1 year of treatment in both arms.Objective: To determine whether ther...

ba0005p464 | Other diseases of bone and mineral metabolism | ECTS2016

The course and management of craniofacial fibrous dysplasia: a case series

Majoor Bas , Appelman-Dijkstra Natasha , Bruggemann Jens , van de Sande Michiel , Dijkstra Sander , Hamdy Neveen

Introduction: Cranialfacial fibrous dysplasia (CFD) presents with pain, facial asymmetry and/or neurological complications. It has been suggested that patients with CFD respond favourably to treatment with bisphosphonates, by a decrease in pain and arrest of progression. Therefore, we performed a retrospective study of 56 patients with CFD in our center.Methods: We assessed clinical characteristics and disease course. Furthermore, clinical and biochemica...

ba0001pp464 | Other diseases of bone and mineral metabolism | ECTS2013

Effects of add-on parathyroid hormone (PTH(1-84)) substitution therapy in hypoparathyroidism: results from 2.5 years of PTH treatment

Sikjaer Tanja , Moser Emil , Rolighed Lars , Mosekilde Leif , Rejnmark Lars

Conventional treatment of hypoparathyroidism with calcium and active vitamin D analogues causes a high renal calcium excretion and over-mineralized bone.We studied 62 patients with hypoPT randomized to 6 months of treatment with either parathyroid hormone (PTH(1-84)) 100 μg/d s.c. or similar placebo, administered as an add-on therapy. Forty-two of the patients had follow-up test performed after 2.5 years; 9 patients had continued daily PTH treatment...

ba0003oc1.4 | Phosphate metabolism, fracture repair and osteoarthritis | ECTS2014

Long-term Fgf23 deficiency induces renal and skeletal PTH resistance in vitamin D receptor-ablated mice

Andrukhova Olena , Murali Sathish Kumar , Zeitz Ute , Erben Reinhold G.

Fibroblast growth factor-23 (FGF23) is a hormone originating from osteocytes with suppressive actions on renal phosphate reabsorption and vitamin D synthesis. We recently identified FGF23 as a calcium-conserving hormone, regulating the membrane transport of the epithelial calcium channel TRPV5 in distal renal tubules. Here, we analyzed the long term sequelae of Fgf23 deficiency and renal calcium wasting on bone and mineral metabolism in 9-month-old mice lacking both Fgf23<...

ba0003oc3.3 | Osteoclasts, gastric hormones and HIF | ECTS2014

Thyroid hormones stimulate osteoclastogenesis via TRα-dependent actions in osteoblasts

Logan John G , Bassett JH Duncan , Williams Graham R

Thyrotoxicosis results in osteoporosis, and thyroid hormone (T3) stimulates osteoclastic bone resorption by unknown mechanisms. We previously demonstrated that knockout mice lacking thyroid hormone receptor α (TRα0/0) are euthyroid but have high bone mass, whereas mice lacking TRβ (TRβ−/−) are thyrotoxic and osteoporotic. Tartrate resistant acid phosphatase (TRAcP) staining revealed osteoclast numbers were reduced by 13% (<...