Bone Abstracts

Leptin and adiponectin have an opposing relationship in circulation; leptin is higher and adiponectin lower in overweight/obese individuals, and vice versa. Studies showed that both leptin and adiponectin can be either beneficial or harmful to bone depending on the mode of action. The objective was to investigate the association of serum leptin:adiponectin ratio (L:A) with BMD of various skeletal sites and markers of bone turnover in overweight and obese postmenopausa...

Introduction: In postmenopausal women with vertebral compression fractures (VCF) the mechanisms regulating healing processes and an anti-osteoporotic treatment are not completely clarified. The aim of this prospective study was the evaluation of bone turnover markers, bone mineral density and radiographic progression of one or more VCF during assumption of risedronate, strontium ranelate or teriparatide.Materials and methods: Women with recent osteoporot...

Introduction: Minodronate, a new-generation bisphosphonate (BP), is the first BP available as a once-monthly oral regimen in Japan. Aside from being a highly potent inhibitor of bone resorption, minodronate has been shown to possess antagonistic action against the P2X2/3 receptor, which has an important role in nociceptive transmission. The purpose of this study was to investigate the analgesic effects of once-monthly oral minodronate (MIN50 mg) on low back pain (LBP) associat...

Introduction: Bisphosphonates (BPs) are currently the mainstay of treatment in osteoporosis; however, the complex dosing regimens might interfere with long-term adherence, which provided the rationale to develop BPs with less-frequent dosing schedules. Minodronate (MIN 50 mg), a highly potent new-generation BP, is the first BP available as a once-monthly oral regimen in Japan. The aim of the present study was to investigate patient preference for, and adherence to, MIN 50 mg i...

Impaired bone material properties have been invoked as being responsible for the development of atypical femoral fractures (AFF) after long term bisphosphonate use. We therefore analyzed bone material properties in a bone biopsy obtained at the fracture site from an 88-year-old female with AFF, who had been treated with alendronate for 8 years. We used conventional histology, quantitative backscattered electron imaging (qBEI), and Raman spectroscopy (RS).<p class="abstext"...

Strontium ranelate (SrR) is now widely used for the prevention of osteoporotic fractures. The mechanisms by which this occurs, however, remain unclear. We investigated the actions of Sr2+ salts in bone-forming cultures of primary osteoblasts from rat calvariae. Osteoblasts were treated continuously with either SrR or SrCl2 for 14 days. Abundant, discretely mineralised ‘trabecular’ bone structures formed in alizarin red-stained control cultures. ...

Conventional treatment of hypoparathyroidism with calcium and active vitamin D analogues causes a high renal calcium excretion and over-mineralized bone.We studied 62 patients with hypoPT randomized to 6 months of treatment with either parathyroid hormone (PTH(1-84)) 100 μg/d s.c. or similar placebo, administered as an add-on therapy. Forty-two of the patients had follow-up test performed after 2.5 years; 9 patients had continued daily PTH treatment...

Introduction: The aim was to examine serum levels of RANKL, OPG and TNF-α before and after curative surgery (PTX) in patients with primary hyperparathyroidism, and their relationship to bone turnover and bone loss.Patients and methods: A 46 patients with rather severe primary hyperparathyroidism (mean PTH=196 pg/ml, mean total Ca=11.4 mg/dl, spine osteoporosis in 50%, hip osteoporosis in a third) mean age of 63.3±12.3 years, 41 women/five males...

Objectives: The Brtl mouse, a unique model for the autosomal dominant forms of osteogenesis imperfecta was used to prove the feasibility of a lentiviral-shRNA-based strategy to improve collagen quality by targeting the mutant Col1a1 allele at the point mutation responsible for the causative substitution Gly349Cys. The ability to specifically suppress the mutant allele should convert the moderate Brtl outcome to the mild one caused by quantitative defect.<p class="...

Objectives: To evaluate bone status and body composition in patients with phenylketonuria and hyperphenylalaninemia.Methods: Eighty patients (48 with phenylketonuria and 32 with hyperphenylalaninemia), aged 5–18 years, early-diagnosed, underwent dual energy X-ray absorptiometry. Bone mineral density (lumbar spine and total body), bone strength (bone mineral content:lean tissue mass ratio), lean tissue mass, body fat percentage, and fat mass index we...