Bone Abstracts

Giant cell tumour of bone (GCTb) is an osteolytic neoplasia with tendency to local recurrence (10–25%), while metastases or malignant transformation are described in 1–4% of cases.It is composed by three distinct populations that cross-talk each other generating unbalance in bone remodeling and activation of NF-kB signaling pathway.To identify new candidate biological markers useful for improving clinical management of GC...

Postmenopausal women with early stage hormone-receptor-positive breast cancer (EBC) are standardly treated with aromatase inhibitors (AIs). However, one side-effect of AIs treatment is a decrease in bone mineral density (BMD) and an increased risk of fracture. The objectives of this study were to examine: i) changes in bone formation (N-terminal propeptide of type I procollagen; PINP) and bone resorption (cross-linked C-telopeptides of bone type I collagen; CTX) markers, as we...

Caffeine is a methylxanthine found in many foods and is widely consumed by the human population. Therefore, its effects and mechanisms in various tissues have been widely studied. Various bone abnormalities have been observed in fetuses from rats treated with caffeine. But the genesis of these abnormalities is not known. The objective of this study was to verify the metabolism and activity of calvaria osteoblasts from offspring of rats treated with caffeine during pregnancy. T...

Background: Among body composition phenotypes there is no consensus on definition and consequences of sarcopenic obese phenotype. The recommended method to quantify the muscle mass is the dual energy X-ray absorptiometry (DXA), based on measurement of total fat mass and appendicular lean mass. A high BMI may provide a great bone mineral density (BMD) in many individuals, but it does not guarantee optimal bone strength. The aim of our study is to investigate the influence of sa...

Background: Sarcopenic obesity is usually defined by the combination of sarcopenia and obesity but there is not a standard definition yet. The recommended method for the quantification of muscle mass is dual energy X-ray absorptiometry (DXA), based on assessment of total fat mass and appendicular lean mass. Low Body Mass Index (BMI) used to be considered as a risk factor for fragility fracture. However, recent evidences have demonstrated a correlation between BMI and vertebral...

Objective: The objective of this observational cross-sectional study is to identify the prevalence of vitamin D deficiency in healthy women in Greece, as reflected by the levels of 25-hydroxyvitamin D (25(OH)D), since recent data indicate that vitamin D deficiency can be common in countries previously considered as low risk (e.g. Mediterranean countries).Materials and methods: A population of 840 community dwelling women was recruited at the health promo...

Patients with type 2 diabetes (T2DM) have an increased risk of hip and vertebral fractures compared to non-T2DM subjects. The bone mineral density (BMD) does not reflect the impaired bone quality in T2DM patients. The aim of the present study was to investigate the relationship between BMD and bone formation (N-terminal propeptide of type I procollagen, PINP; osteocalcin, OC) and bone resorption (cross-linked C-telopeptides of bone type I collagen, CTX) markers, as well as cha...

Background: Zoledronic acid (ZA) is associated with a transient post-infusional acute phase reaction (APR) due to the activation of γδTCR lymphocytes (γδTcells).Aims: To investigate if APR correlates with γδTcell percentage or cytokine polarization, or with 25-OH vitamin D levels; to identify a 25-OH vitamin D level associated with a lower risk of APR.Methods: Sera for ELISA test (IFNγ, IL17, and ...

Denosumab (DNMB) is an effective treatment for osteoporosis with antiresorptive effect that has demonstrated to increase the bone mass and reduces the incidence of both vertebral and nonvertebral fractures in randomized controlled trials (RCTs).Objectives: To confirm that this drug is actually effective in our experience into daily clinical practice as well.Material and methods: 30 postmenopausal women, mean age 71 years (r</em...

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, auto-inflammatory disorder of unknown cause that affects children and adolescents. CRMO is characterized by periodic bone pain, fever, multiple bone lesions occurring at any skeletal site, even if the metaphyseal area of long bones, clavicle and shoulder girdle are the most common locations. Dermatological manifestations include psoriasis, acne and pustules. The clinical and radiological features of the disease are v...