Bone Abstracts

A osteoporotic fracture has become a global health issue that causes tremendous impact on mortality as well as heavy socioeconomic burden. Previous studies suggested that vitamin D may prevent fractures by improving muscle mass as well as via increasing bone density directly. The purpose of the study is to determine that the influence of vitamin D on bone mineral density depends on its effects on muscle mass.We analyzed the data from Korean National Heal...

Objectives: The correlation between vitamin D and GH–IGF1 axis is documented. Growing children, need extra Vit-D because it is required for growth. Severe deficiency in Vit-D generates poor growth. Height is usually more affected. Growth hormone (GH) deficiency in children causes severe growth retardation, Vit-D deficiency, and osteopenia. The aim of this presentation was: 1. To evaluate the Vit-D blood level to children in substitution treatment with rhGH. 2. To see if t...

Aim: Determining level of vitamin D and other conditions in children with osteoporosis.Methodology: Bibliography review in a worldwide basis about the issue and what we have observed.Outcome: We studied the level of 25OHD3 in all patients with osteoporosis and osteopenia. 25OHD3 95% deficit was found in these patients when reduced bone mass occurs. There are several disorders for hypocalcemia. Intestinal malabsorption syndromes, re...

Objectives: Single nucleotide polymorphisms (SNP) in genes related to vitamin D metabolism have been associated with 25-hydroxyvitamin D (25(OH)D) status, but these relationships have not been examined in pregnancy or following antenatal vitamin D supplementation. We assessed whether SNPs in DHCR7 (7-dehydrocholesterol reductase), CYP2R1 (25-hydroxylase), CYP24A1 (24-hydroxylase) and GC (Vitamin D binding protein) were associated with the re...

Introduction: Vitamin D deficiency has been associated with impaired physical functioning and several chronic diseases and might thereby affect quality of life and self-rated health. The aim of this study was to assess relationships of serum 25-hydroxyvitamin D (25(OH)D) with quality of life and self-rated health, and to examine whether physical performance and number of chronic diseases mediate these relationships.Methods: Data were obtained from the LA...

The aim of the work was to determine the influence of vitamin D deficiency on bone mineral density in schoolchildren.Methods: There were examined 304 children aged 10–18 years. The boys consisted 55.0%. The average age of boys was 12.9±0.2 and girls – 12.4±0.2 years old. Researches included ultrasound densitometry of calcaneus by SAHARA (Hologic), blood chemistry, 25(OH)D and intact parathyroid hormone (iPTH) in plasma were determined...

Objectives: The linear growth of child is characterized by the presence of phases of growth spurt which allowed to rich the peak growth to the end of puberty. Acceleration of velocity of linear growth required the adequate calcium and vitamin D supplementation necessary for mineralization of bone matrix and osteoblast proliferation.The aim of our study was to evaluate changes of serum concentrations of vitamin D during the growth phases.<p class="abs...

Objectives: Vitamin D deficiency is of current interest especially in high risk patients for reduced bone mineral density as in pediatric hematologic oncologic patients.Methods: During a 4 year period 194 pediatric hematologic oncologic patients were screened for serological vitamin D deficiency (defined as 25 (OH)D levels <30 ng/ml and accordingly <75 nmol/l). 61 patients were in the prospective group 1 defined as screening at time of diagnosis,...

Objectives: Study the prevalence of hypovitaminosis D in chronically ill children in Greece, as well the efficacy of a proposed replacement therapy.Methods: A total number of 213 children (121 males and 92 females), with mean age 10.1 years (1–18), suffering various pathological conditions (cerebral palsy, Duchenne myopathy, epilepsy), were sampled to measure serum 25(OH)D and parameters of bone turnover. 101 children were given replacement therapy ...

Data on the prevalence of vitamin D deficiency/insufficiency in children with haematological malignancies (HM) in Sweden are scarce. Our studies indicate that one third of children with HM had vitamin deficiency/insufficiency already at the time of diagnosis. In this study, we aimed to investigate the impact of season and age at HM onset on vitamin D status by analysing 25(OH)D levels in two different age groups: children ≤6 years of age, and children >6 years of age...