Bone Abstracts

Benign jaw tumors including ossifying fibroma (OF) can be often incidentally diagnosed due to their slow-growing and painless characteristics. In cases of massive growing jaw tumors, it can result in deformity of teeth, infection and intracranial complications. Depending on the location of tumor lesion, it may not completely resected and recur after the primary operation, which may require subsequent operations.Molecular mechanisms and the etiology of th...

C-C chemokine receptor 5 (CCR5) is a co-receptor of macrophage-tropic viruses including HIV. Epidemiological and pathological findings have reported that functional changes in CCR5 correlate with HIV transmission bone destruction disease. However, the roles of CCR5 in bone pathophysiology have not been well documented.Ccr5-deficient osteoclasts showed decreased bone resorption activity accompanied with disorganized cellular architecture and impa...

Distal-less homeobox 5 (Dlx5) is a transcription factor that enhances osteogenic differentiation of mesenchymal stem cells via upregulating the expression of Runx2 and other osteoblast phenotypic genes. We have previously demonstrated that Dlx5 also downregulates adipogenic differentiation of mesenchymal stem cells and that insulin decreases expression levels of Dlx5 via increasing expression levels of miR-124, a microRNA targeting 3′UTR of Dlx5. However, the mechanism o...

Sphingosine-1-phosphate (S1P) is a significant regulator of bone metabolism. Recently, we found that a high plasma S1P level is associated with low bone mineral density (BMD), high levels of bone resorption markers, and a high risk of prevalent vertebral fracture in postmenopausal women. We investigated the possibility that S1P is a predictor of incident fracture. A total of 263 postmenopausal women participated in this longitudinal study and received follow-up for a mean dura...

Introduction: As Korean society have been entered to aging population, osteoporosis is considered one of the most important disease in the elderly. Osteoporotic vertebral compression fractures can affect to patient’s quality of life. But, in Korea, there is few studies about this, so we investigated.Aim: To evaluate the quality of life of patients with vertebral compression fracture.Methods: This study was performed in multice...

Introduction: The purposes of this study were to evaluate the trends in the incidence and mortality of hip fracture between 2008 and 2012, and predict the number of hip fractures in Korea up to 2025, using nationwide claims data.Methods: Nationwide claims data managed by the National Health Insurance Service (NHIS) was used to identify patients with hip fracture. All new visits or admissions to medical institutes for hip fracture aged 50 years or more be...

Introduction: Vertebral fracture has been recognized as a major health concern. Our purposes were to evaluate the trends in the incidence and mortality of vertebral fracture between 2008 and 2012 and predict the number of vertebral fracture that will occur in Korea up to 2025, using nationwide data from the National Health Insurance Service (NHIS).Method: A nationwide data set was evaluated to identify all new visits to medical institutes for vertebral f...

Nutrition is a major modifiable factor that affects bone health. Dietary potassium may act as an alkaline source by neutralizing the acid load and reducing calcium loss from bone.We aimed to evaluate the association between dietary potassium intake and bone mineral density (BMD) in the Korean population. We analyzed data from the Korean National Health and Nutrition Examination Survey (KNHANES) A total of 3135 men aged >50 years and 4052 postmenopaus...

The present study figured out the relationship between social network and osteoporosis among elderly women. Social network could be beneficial to one’s health since it works as social capital providing several supports. On the other hand, social network can also be a source of social burden aggravating one’s health. To examine the seemingly contradicting associations, Korean Urban Rural Elderly Study (KURE) data was analyzed. There were 1938 older women aged over 65,...

Background: Denosumab (DMAB) is used in adults for the treatment of osteoporosis, giant cell tumour of bone, and cancer metastases. There are little data on paediatric use with clinical decision making reliant on adult data and clinical experience.Presenting problem: We have treated 33 children with DMAB: Perthes disease (n=9), avascular necrosis (n=17), osteoporosis (n=1), aneurysmal bone cyst (n=4) and giant cell tum...