Bone Abstracts

Background: Primary de Toni-Debré-Fanconi syndrome is a metabolic disorder characterized by hypophosphatemic rickets or osteomalacia, renal tubular acidosis, renal glycosuria, generalized aminoaciduria. It is a non-FGF23-mediated hypophosphatemic disorder, with primary defect in proximal tubular dysfunction. The orthopaedic sequela of this rare disorder in the literature is scarce.Presenting problem: We present a clinical case of a 10-year-old femal...

Lipid raft microdomains have important role in cellular signaling. Caveolae are a specialized type of lipid rafts that are stabilized by oligomers of caveolin protein. Here we showed that caveolin-1 (Cav-1) is a critical membrane structural protein of osteoclast. In microarray analysis, we found that caveolin-1 was significantly up-regulated by RANKL. Knock-down of Cav-1 in bone marrow derived-macrophage reduced osteoclastogenesis. Consistent with the in vitro results...

Bisphosphonates (BPs) are widely used as antiresorptive drugs. However, one of most potent BPs, zoledronic acid (ZA) can cause BP-related osteonecrosis of the jaws (BRONJ) with a poorly understood pathophysiology. The aim of this study was to find a clue for the development of BRONJ by evaluating the cytotoxic effects of ZA on osteoblasts and examining the action mechanism of ZA on osteoclast differentiation. Jaw bone osteoblasts (JB-OBs), long bone osteoblasts (LB-OBs), and b...

Bisphosphonates (BPs) are widely used for treating osteoporosis and preventing osseous metastasis or hypercalcemia in cancers. However, osteonecrosis of the jaw in patients treated with BP after dentoalveolar surgery has been increasing, especially in those treated with strong BPs such as zoledronate (ZA). The pathobiology underlying the occurrence of osteonecrosis only in the jaw bone remains unclear. The objective of this study was to compare the effects of BPs on the in...

Background: There have been many studies on the association between vitamin D and testosterone in the world. But it has not been fully clarified. Furthermore, data in Korean men is limited. This study aimed to determine the association between vitamin D and testosterone levels in korean men.Methods: This cross sectional study analyzed serum 25-hydroxyvitamin D (25(OH)D) and total testosterone in 365 Korean men over 25 years of age who visited a local uni...

Osteoporosis is known to be associated with metabolic diseases characterized by insulin resistance, such as central obesity, diabetes, and metabolic syndrome. Non-alcoholic fatty liver disease (NAFLD) is also increased in such insulin resistant conditions. However, little is known about whether osteoporosis and nonalcoholic fatty liver disease are etiologically related to each other or not. We investigated whether bone mineral density(BMD) is associated with NAFLD in pre- and ...

Purpose: Osteoporosis is a progressive bone disease that is characterized by a decrease in bone mass, density and destruction of microstructure, which can lead to an increased risk of fracture. Although many studies have been published about relationship between end-stage renal disease and osteoporosis, but research on the relationship between proteinuria and the prevalence of osteoporosis is still lacking.Methods: We assessed 91 postmenopausal women wit...

Objectives: There are some studies that evaluated changes of bone marrow density (BMD) and re-fracture after zoledronic acid injection. However, there is no study that showed about the fracture on all of the body, fracture healing, and improvement of clinical symptom after zoledronic acid injection. In this study, authors evaluated the 1 year BMD change, changes of lumbar pain in lumbar spine fractures, effects on fracture healing, re-fracture and additional fracture on other ...

Introduction: Percutaneous vertebroplasty is a well known surgical method to put the bone cement at osteoporotic vertebrae. There was a few report concerning about bone cement related complication such as dislodgment of injected cement. There are some contradictory study for long term reaction to bone cement in osteoporotic bone, especially injected cement features. This study is to assess the radiographic features of patients who underwent percutaneous vertebroplasty (PVP) in...

Evidence indicates that dipeptidyl-peptidase 4 (DPP4) plays a distinct role in bone metabolism. However, there has been no report on the association, if any, between circulating DPP4 levels and osteoporosis-related phenotypes. This study aimed to determine if DPP4 predicts osteoporotic fracture (OF) risk in postmenopausal women. This case–control study was conducted in multiple centers in Korea. We enrolled 178 cases with OF and 178 age- and body mass index-matched contro...