Bone Abstracts

Objective: The aim of this study was to assess the association between bone mineral density (BMD) and coronary atherosclerosis in healthy postmenopausal women.Methods: We performed a retrospective review of 252 postmenopausal women who visited the health promotion center for a routine checkup, after excluding participants who had factors affecting BMD and coronary artery disease. BMD of the lumbar spine and proximal femur was evaluated by dual-energy X-r...

Introduction: To analyze clinical assessment and efficacy of once-yearly i.v. zoledronic acid for osteoporosis.Materials and methods: The subjects were 322 osteoporotic patients who received more than single infusion of zoledronic acid in our hospital from October 2008 to March 2011. On clinical assessment, the adherence was evaluated by measuring the rate of reinfusion. Adverse events were recorded for safety assessment. For efficacy assessment, the bon...

Objective: The aim of this study was to assess the relationship between renal function (estimated glomerular filtration rate (eGFR) using Cockcroft–Gault (CG) equation and modification of diet in renal disease (MDRD), respectively), bone mineral density (BMD) and both arterial stiffness in Korean postmenopausal women.Materials and methods: From January 2008 until December 2010, among the person who got medical examinations including bone densitometr...

Purpose: Osteoradionecrosis (ORN) of the mandible is a serious complication of radiation therapy, and preceded by soft tissue damage before bone loss appears. However, there is still no adequate treatment to heal the soft tissue damage of ORN. This study investigated the effect of PDGF-BB or mesenchymal stem cells (rMSCs) on radiation-induced soft tissue injury.Methods: Rat model was designed to irradiate the skin of SD rats while sparing the body and in...

Objectives: Metabolic bone disease is a frequent complication of end-stage renal disease, characterised by a decreased bone mineral density, which can be measured with dual-energy X-ray absorptiometry. Its validity as a marker for clinical bone disease and increased fracture risk has never been established in adults with pediatric onset of end-stage renal disease (1–3). Adult survivors of pediatric end stage renal disease have very low bone mineral density and small statu...

Melatonin is a neuro-hormone released primarily from the pineal gland, which has been shown to have bone anabolic effect, although it is still unclear whether its skeletal action is directly mediated by receptors expressed on bone cells or is indirect. In this study, we examined melatonin’s effects on bone cellular activities in vitro and tested whether it modifies angiogenesis and blood flow to bone, which are both essential for bone formation.<p class="abst...

Introduction: Hypertrophy of ligamentum flavum (LF) induces narrowing of spinal canal which develops neurogenic claudication. Several mechanisms of LF hypertrophy have been suggested. Among them inflammatory cytokine play a crucial role in LF hypertrophy by increasing collagen synthesis. Cyclooxygenase-2 (COX-2) pathway shares inflammatory reaction from infection and arthritis. Selective COX-2 inhibitor (COX-2si) might modulates collagen synthesis via suppressing inflammatory ...

Objectives: To evaluate risk factors of subsequent vertebral fracture following acute osteoporotic vertebral compression fracture.Methods: As a multicenter retrospective study, we recruited 135 patients treated for acute osteoporotic compression fracture with available spine image taken at 1-year follow-up in three hospitals. The patients were divided into two groups according to occurrence of subsequent vertebral fracture. Two groups were analyzed with ...

The purpose of this study is to understand the changes of TBS scores in Asian females by comparing 1990’s and 2010’s DXA images.We have compared the DXA images of 3774 Korean females (age: 20–79) to Japanese (age: 20–79). While Korean DXA images were obtained in 2014 and 2015, Japanese data were obtained in 1996. Participants who have abnormal DXA images or lumbar disease were excluded. TBSiNsight® software (v. 2.1.1, ...

The purpose of this study is to assess the correlation of trabecular bone score (TBS) to variable factors, i.e. sex, age, body size and BMD. Moreover, we want to find variables of correlation coefficient change with aging.We randomly selected 2,906 subjects (1726 female and 1180 male, age range 20’s to 70’s) from several hospitals in Korea. Participants who have abnormal Dual Energy X-ray Absorptiometry (DXA) images or lumbar disease were exclu...