Bone Abstracts

Objective: The purpose of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in leptin (LEP), its receptor (LEPR) and β adrenergic receptor (ADRB) genes and bone mineral density (BMD) in postmenopausal Korean women.Methods: The LEP c.280G>A, LEPR c.326A>G, c.668A>G, c.1968G>C, c.2096C>T, ADRB2 c.46A>G, c.79C>G, c.718T>C, c....

Ablation of osteosarcoma cells by sublethal hypothermia before radiation may increase sarcoma tissue sensitivity by inducing growth arrest. Normal cells that are not lethally damaged by hypothermia and radiation can undergo DNA repair thus promoting cell survival. Nevertheless, understanding of the response of normal bone forming osteoblast cells towards hypothermia is necessary before administering on osteosarcoma cells. In this study we evaluated the response of short-term m...

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Study aim: Vertebral strength is determined by bone size, shape, bone mineral density, microarchitecture, and bone material properties. Despite its importance to vertebral mechanics, no studies have reported on the variation of bone microdamage present in the human vertebra. Thus, the aim of this study was to assess regional changes in trabecular bone microdamage in association with bone microarchitecture and resorption in whole human lumbar vertebrae.Me...

Study aim: The general assumption that changes in bone microstructure and material properties at the iliac crest are representative of skeletal sites that are susceptible to osteoporotic fracture has not yet been addressed. Therefore, our study aim was to perform a comparative analysis of bone microarchitecture, accumulated microdamage and osteocyte morphology between the iliac crest, proximal femur and vertebral body.Methods: Trabecular bone cores were ...

Introduction: Vitamin D is an essential material in bone metabolism, and regulation of body minerals. Vitamin D deficiency has various causes, including limitations in sunlight exposure (type of clothing, sunscreen usage, indoor activity), seasonal geographic latitude and altitude, atmospheric pollution, diet, and ageing.The aim of the work was to determine the frequency of vitamin D deficiency among Ukrainian schoolchildren and its influence on bone min...

The cathepsin K inhibitor odanacatib (ODN) is a bone formation-sparing inhibitor of osteoclastic resorption activity. This drug is currently under development for the treatment of postmenopausal osteoporosis. To support the bone safety profile of ODN, we evaluated the effects of ODN on trabecular bone hard tissue properties in the estrogen-deficient model of the ovariectomized (OVX) rhesus monkeys. Animals (n=16/group, age 11–22 years) were treated immediately af...

Introduction: Acromegaly is a rare disease caused by excess growth hormone (GH) production by an adenoma of the anterior pituitary gland. The skeletal complications of GH and IGF-1 excess include increased bone turnover, increased cortical bone mass and deteriorated microarchitecture of trabecular bone, associated with a high risk of vertebral fractures in the presence of a relatively normal Bone Mineral Density (BMD). There are no data on bone material properties in patients ...

Osteoporosis is the commonest worldwide age-related bone disease. It is clinically symptomless until the first fracture happens. Circulating microRNAs can be used as novel biomarkers to assess health status and progression of complex diseases. A recent review highlighted the involvement of microRNAs in the control of bone formation and remodeling. Most of these studies have been done on animal models, but few on human blood samples.This research aims to ...

Odanacatib (ODN), a selective and reversible cathepsin K inhibitor was shown to histomorphometrically reduce trabecular (Tb) and intracortical (Ic) bone remodeling while preserving endocortical (Ec) and stimulating periosteal (Ps) bone formation (BF) in monkeys. Here, we investigate the bone site specific mechanism of ODN on bone modeling (Mo) versus remodeling (Re)-based osteons. Rhesus monkeys (13–19 yrs, n=8–11/group) were ovariectomized and treated with ...