Bone Abstracts

Background: Children with special needs may be greater risk of vitamin D deficiency due to decreased mobility and outdoor play, concomitant medications that increase catabolism of vitamin D, reduced nutritional intake and low body weight. Gastrostomy-fed children receiving a nutritionally complete formula may still be at risk of vitamin D deficiency due to the above factors.Objective: The objective of this study is to assess the vitamin D status of speci...

There is a similarity of the mechanisms of physiological and pathological mineralization. Pathological calcification of soft tissues as the case of vascular calcification is characterized by the deposition of hydroxyapaptite induced by matrix vesicles at least in the initial stage as in the case of physiological calcification in skeletal tissues. Lipid metabolism is involved in the differentiation of smooth muscle cells and bone cells suggesting that phospholipases can modulat...

Recent meta-analyses of vitamin D without co-administration of calcium have not demonstrated fracture prevention, possibly through lack of power, inappropriate choice of doses, or failure to target the intervention to deficient populations. Bone mineral density (BMD) is able to detect biologically significant effects in much smaller cohorts, so is a relevant surrogate measure with which to re-assess the skeletal efficacy of these supplements. We searched Web of Science, Embase...

Low circulating levels of total 25-hydroxyvitamin D (25OHD) have been reported in obese people of different ethnicities in several countries. Low total 25OHD in obesity could be due to lower binding proteins (with normal free 25OHD), lower dietary intake or sunlight exposure, greater volume of distribution (pool size) or more rapid metabolic clearance.The aims of this study were to determine if free 25OHD and 1,25-dihydroxyvitamin D (1,25(OH)2...

Introduction: Although systemic lupus erythematosus (SLE) has traditionally been considered a disease of women, men may also be afected. Male osteoporosis is increasingly recognised. Several studies have reported that mean bone mineral density is significantly reduced in SLE women patients and most of them have low levels of vitamin D. The aim of our study is to analize this situation in men.Objectives: Determine 25-hydroxyvitamin-D (25OHD) serum concent...

This investigation sought to assess the relationship between vitamin D and calcium intake and estimated bone stiffness as assessed by multisite quantitative ultrasound (mQUS) in a large cohort. A total of 1177 men and 2949 women were assessed with mQUS (Beam-Med Omnisense quantitative ultrasound; Isreal) at the distal radius, tibia, and phalanx sites as part of the Canadian Multicentre Osteoporosis Study (clinical sites included Saskatoon, Calgary, Hamilton, Quebec City, Halif...

Background: Optimal intake of calcium and vitamin D of pregnant women is an important component for the normal course of pregnancy, but here are the contradictory opinions about the case of shortage of the consumption, there is no uniform approach to the appointment of them.Aim: To assess the level of consumption of alimentary calcium, and characteristic of the status of vitamin D and calcium in blood serum of pregnant women.Materi...

The aim of the research was to determine the efficacy of alfacalcidol (Alpha D3 Teva) in the treatment of women with postmenopausal osteoporosis and vitamin D deficiency.Methods: 20 women with systemic postmenopausal osteoporosis were examined. All patients had vitamin D deficiency (the average level of 25(OH)D in blood serum was (37.16 (24.9, 45.1)) nmol/l). Alfacalcidol was prescribed for 12 month in doses 1 μg. duration of observation was 12 mont...

Introduction: Treatment in thyroid function disorders, which lead to clinical hypothyroidism, is replacement with levothyroxine. We aimed to investigate the effect of long-term levothyroxine therapy on vitamin D metabolism and bone mineral density in children.Materials and methods: Twenty-seven children with hypothyroidism receiving levothyroxine therapy (M/F: 13/14, mean age, 12.1±0.7 years) and 21 healthy controls (M/F: 13/8, mean age, 11.8±0...

Fractures in infancy raise the spectre of child abuse; it has been suggested that lack of vitamin D could result in bone abnormalities that could predispose to fractures. We utilised a mouse model system to investigate whether vitamin D deficiency in utero alters early bone growth and development.C57BL/6 female mice received vitamin D deficient or replete diet for 6 weeks, then mated and continued on their respective diets until weaning. Pups were culled...