Bone Abstracts

Objectives: Glucagon-like peptide 1 is secreted by intestinal L-cells into the blood supply in response to nutrients in the intestine. Although osteoblasts express the GLP-1 receptor (GLP-1R), the main action of the GLP-1/GLP-1R pathway in bone physiology and bone quality is unknown. The aim of the present study was to investigate bone strength and quality in a mouse model of GLP-1R deficiency.Materials/methods: Eight 16 weeks-old GLP-1R knock-out male m...

Objectives: Glucose-dependent insulinotropic polypeptide (GIP) is secreted by intestinal K-cells into the blood supply in response to nutrient ingestion and absorption. Although osteoblasts and osteoclasts express the GIP receptor (GIPR), the main action of the GIP/GIPR pathway in bone physiology and bone quality is unknown. The aim of the present study was to investigate bone quality in a mouse model of GIPR deficiency.Materials/methods: Eleven 16 weeks...

The aim of this study was to evaluate the effect of anabolic PTH on periodontal repair and mandibular bone defect in rats. Fenestration defects were created unilaterally of lower first molars in Wistar rats (n=32), and both periodontal ligament and cementum were removed. Animals were treated 3 times a week and then assigned to four groups (n=8): i) C14 – placebo administration for 14 days; ii) P14 – PTH administration for 14 days; iii) C21 – pl...

This study aims at determining if casein would lead to a better bone status than soy in the context of a moderate protein restriction (6% of total energy intake) in growing mice.Ten-week-old female Balb/C mice were divided in four groups of 15 animals. Two groups received 6% of their energy intake as protein, one as casein and the other as soy protein. The third group was a normal-protein control receiving 20% soy protein. The last group (positive contro...

An IgM monoclonal gammopathy (MGUS) is often the first sign of a lymphomonocytic B-lymphoma (Waldenström macroglobulinemia-WD). Osteolytic lesions can occur in B cell malignancies (WD, hairy cell leukemia, LLC\..) but are less frequent than in myeloma. In addition, bone remodeling in WD is poorly understood. However, an osteoporosis is often observed in MGUS patients. We studied a series of bone biopsies performed in patients with an IgM gammopathy by histomorphometry, mi...

Introduction: The creatine kinase (CK) is a dimeric enzyme, involved in energetical metabolism. It is present in many tissues, but higher concentration in skeletal and cardiac muscle.Therefore, conditions that involve muscle tissue may increase this serum enzyme. Such enzyme elevation is usually observed in inflammatory myopathies and others autoimmune diseases.Sometimes some elevation in CK is not fully understood out off these co...

Purpose: Denosumab is a new potent antiresorptive treatment of osteoporosis that can potentially induce a compensatory increase of parathyroid hormone (PTH) levels. We aimed to evaluate the alteration of PTH 1 and 6 months after denosumab’s administration (60 mg) with different regimens of calcium and vitamin D (Ca/D) supplementation, as well as the association of PTH with serum Ca and bone markers.Methods: This was a prospective, multicenter, study...

Introduction: The aim was to examine serum levels of RANKL, OPG and TNF-α before and after curative surgery (PTX) in patients with primary hyperparathyroidism, and their relationship to bone turnover and bone loss.Patients and methods: A 46 patients with rather severe primary hyperparathyroidism (mean PTH=196 pg/ml, mean total Ca=11.4 mg/dl, spine osteoporosis in 50%, hip osteoporosis in a third) mean age of 63.3±12.3 years, 41 women/five males...

Objectives: CKD in children is associated with suppressed body growth. Physical activity has been previously shown to increase expression of IGF1 signaling in muscles of rats with CKD, but the effects of this intervention on bone tissue have not been investigated yet. The purpose of this study was to examine the effects of aerobic exercise on CKD related bone disease.Methods: Twenty-day old/50 g male rats underwent a two step subtotal nephrectomy (Nx) or...

Introduction: Osteogenesis imperfecta (OI) is characterized by low bone mass, skeletal fragility and, frequently, short stature. We previously showed in oim/oim mice that sclerostin inhibition increased bone mass, mineral content and strength. Here, we compared the body length and the sizes of long bones, head and vertebrae between oim/oim and wildtype mice and analyzed the effect of sclerostin antibody (Scl-Ab) on these parameters.Materials and methods:...