Bone Abstracts

Introduction: Hypertrophy of ligamentum flavum (LF) induces narrowing of spinal canal which develops neurogenic claudication. Several mechanisms of LF hypertrophy have been suggested. Among them inflammatory cytokine play a crucial role in LF hypertrophy by increasing collagen synthesis. Cyclooxygenase-2 (COX-2) pathway shares inflammatory reaction from infection and arthritis. Selective COX-2 inhibitor (COX-2si) might modulates collagen synthesis via suppressing inflammatory ...

The purpose of this study is to assess the correlation of trabecular bone score (TBS) to variable factors, i.e. sex, age, body size and BMD. Moreover, we want to find variables of correlation coefficient change with aging.We randomly selected 2,906 subjects (1726 female and 1180 male, age range 20’s to 70’s) from several hospitals in Korea. Participants who have abnormal Dual Energy X-ray Absorptiometry (DXA) images or lumbar disease were exclu...

Background: Asian-specific prediction model for estimating the individual risk of osteoporotic fracture was rare. We aimed to develop a Korean fracture risk prediction model using clinical risk factors and assess external validity of the final model.Methods: A total of 718,306 Korean men and women aged 50–90 were followed for 7 years in national system based cohort study. Fifty percent were randomly assigned to the development dataset and 50% to the...

Background: In 2004, we reported a 48.1% prevalence of osteoporosis in an Ibansung cohort. The current prospective intervention study was undertaken in order to estimate the prevalence of osteoporosis from 2004 to 2015 and the increasing treatment rate of osteoporosis following osteoporosis screening tests with ultrasound bone densitometry and education in the same cohort.Methods: From November 1, 2014 to August 31, 2015, 960 adults ≥50 years of ag...

Introduction: Norway has one of the highest reported incidences of osteoporotic fracture. Since, bone mineral density (BMD) is a strong predictor of future fracture risk, high peak bone mass achievement is essential. This study is the first to examine BMD in a population-based study including Norwegian adolescents. Here we compare the measured BMD with international reference ranges and explore predictors of BMD in this population.Methods: In 2010–2...

Objectives: To evaluate bone status and body composition in patients with phenylketonuria and hyperphenylalaninemia.Methods: Eighty patients (48 with phenylketonuria and 32 with hyperphenylalaninemia), aged 5–18 years, early-diagnosed, underwent dual energy X-ray absorptiometry. Bone mineral density (lumbar spine and total body), bone strength (bone mineral content:lean tissue mass ratio), lean tissue mass, body fat percentage, and fat mass index we...

Poor bone mineralization remains a major health problem in patients with Thal and has been linked to functional zinc deficiency despite adequate dietary intake. The global etiology of poor bone mineralization includes inadequate dietary intake of calcium and vitamin D, endocrinopathies leading to disturbed calcium homeostasis, dysregulation of the GH–IGF1 axis, and delayed puberty, all resulting in limited growth, decreased bone formation and increased bone resorption. Th...

Background: The prevalent vertebral fracture (VF) is a risk factor for future VF, which can be decreased with drug therapy. However, most VFs are not recognized clinically. VFA by DXA and spine X-ray can be performed to detect these prevalent VFs.Objectives: This study aimed to estimate the costs, effectiveness, and radiation exposure of VF diagnostic strategies.Methods: Markov model over a 10-year period was used to calculate the ...

Objective: The purpose of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in leptin (LEP), its receptor (LEPR) and β adrenergic receptor (ADRB) genes and bone mineral density (BMD) in postmenopausal Korean women.Methods: The LEP c.280G>A, LEPR c.326A>G, c.668A>G, c.1968G>C, c.2096C>T, ADRB2 c.46A>G, c.79C>G, c.718T>C, c....

Mechanical stress and strain generated by physical exercises or the other passive stimulations are well known to have a positive effect on the growing musculoskeletal system. Especially, when the impact stimulation which evokes high magnitude of strain in a second is applied to bone, it improves bone qualities. Thus, to verify the effect of impact stimulation, we conducted longitudinal study on morphological properties of the tibia in growing rats. Free falls from designated h...