Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

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ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...
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ba0001op29 | Pre-Clinical | ECTS2013

miR-192 impairs invasion and tumor-induced osteolysis by repressing CCL2 in bone metastatic colonization

Valencia Karmele , Luis-Ravelo Diego , Bovy Nicolas , Martinez-Canarias Susana , Ormazabal Cristina , Zandueta Carolina , Anton Iker , Struman Ingrid , Tabruyn Sebastien , Segura Victor , De Las Rivas Javier , Bandres Eva

see PP154....
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ba0001pp154 | Cancer and bone: basic, translational and clinical | ECTS2013

miR-192 impairs invasion and tumor-induced osteolysis by repressing CCL2 in bone metastatic colonization

Valencia Karmele , Luis-Ravelo Diego , Bovy Nicolas , Martinez-Canarias Susana , Ormazabal Cristina , Zandueta Carolina , Anton Iker , Struman Ingrid , Tabruyn Sebastien , Segura Victor , De Las Rivas Javier , Bandres Eva

Emerging evidence suggests that miRNAs (miR) can modulate a complex gene network in a cell-intrinsic and non-cell autonomous manner. We previously identified by transcriptomic analysis miR-192 to be heavily downregulated in different highly metastatic subpopulations (HMS) isolated from bone metastases in a lung cancer mice model, but its mechanistic contribution to the prometastatic activity remains unknown.To delineate the pleiotropic functions elicited...
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ba0002p137 | (1) | ICCBH2013

Influence of nutritional status in the bone mass assessed by phalangeal quantitative ultrasound of girls aged 7–10 years old

Bertapelli Fabio , Goncalves Ezequiel M , Barbeta Vinicius J O , Krahenbuhl Tathyane , Ramalho Luis C B , Martin Juan E Samur-San , Ribeiro Roberto R , Guerra-Junior Gil

The childhood obesity is a global epidemic. Some studies with pre-pubertal children reported a positive relationship between fat mass and bone. However, there are no available data on the influence of the nutritional status on parameters of quantitative ultrasound (QUS). The aim of this study was to evaluate the influence of nutritional status in bone mass assessed by QUS of proximal phalanges in girls. The bone mass parameter, amplitude dependent speed sound (AD-SoS) in meter...
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ba0003pp373 | Other diseases of bone and mineral metabolism | ECTS2014

Involvement of Gla rich protein with pathological calcification during osteoarthritis. Insights into its γ-carboxylation status

Rafael Marta , Cavaco Sofia , Viegas Carla , Santos Sofia , Ramos Acacio , Luis Ines , Costa Ruben , Willems Brecht , Herfs Marjolein , Theuwissen Elke , Vermeer Cees , Simes Dina

Gla-rich protein (GRP) is a vitamin K-dependent protein, characterized by a high density of γ-carboxylated Glu residues and high calcium binding affinity. It was shown to accumulate in mouse and sturgeon cartilage and in sites of skin and vascular calcification in humans. Four alternatively spliced transcripts of the GRP gene (GRP–F1, F2, F3 and F4) were described in mouse chondrocytes and zebrafish. Osteoarthritis (OA) is a common degenerative joint disease...
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ba0005cabs.oc1.1 | Oral Communications | ECTS2016

Secreted YB-1 (Y-box binding protein 1) as a biomarker of bone disease progression in patients with breast cancer and bone metastases

Bettencourt Maria , Ferreira Arlindo , Alho Irina , Lucia Costa Ana , Sousa Ana Rita , Mansinho Andre , Abreu Catarina , Pulido Catarina , Macedo Daniela , Vendrell Ines , Pacheco Teresa , Costa Luis , Casimiro Sandra

YB-1 (Y-box binding protein 1) is a multifunctional cold-shock protein that has been implicated in all hallmarks of cancer. Elevated YB-1 protein levels were correlated with poor prognosis in several types of cancers, including breast cancer (BC). In BC, high YB-1 expression is a marker of decreased overall survival (OS) and distant metastasis-free survival across all subtypes. YB-1 is also secreted by different cell types and may act as an extracellular mitogen. Therefore, ou...
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ba0005cabs.oc3.1 | Oral Communications | ECTS2016

Blockade of C5aR impairs tumor-induced osteoclastogenesis preventing bone metastasis colonization in lung cancer

Ajona Daniel , Zandueta Carolina , Corrales Leticia , Pajares Maria J. , Martinez-Terroba Elena , Perurena Naiara , Montuenga Luis M. , Pio Ruben , Lecanda Fernando

C5aR is a membrane-associated receptor for C5a, a potent immune mediator generated after complement activation. C5aR expressed in tumor infiltrating immune cells creates a favorable microenvironment for tumor progression. However, the expression of C5aR by cancer cells and its contribution to their malignant phenotype is poorly understood. Immunohistochemical analysis revealed that high levels of C5aR in human lung tumors were associated with poor survival (P=0.005) a...
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ba0005op28 | Pre-Clinical (1) | ECTS2016

Neuropetide Y Y1 receptor deletion impairs matrix demineralization and resorption

Sousa Daniela M , Conceicao Francisco , Leitao Luis , Neto Estrela , Alves Cecilia J , Alencastre Ines S , Herzog Herbert , Aguiar Paulo , Lamghari Meriem

see P194....
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ba0005p194 | Cell biology: osteoclasts and bone resorption | ECTS2016

Neuropetide Y Y1 receptor deletion impairs matrix demineralization and resorption

Sousa Daniela M , Conceicao Francisco , Leitao Luis , Neto Estrela , Alves Cecilia J , Alencastre Ines S , Herzog Herbert , Aguiar Paulo , Lamghari Meriem

Neuropeptide Y Y1 receptor (Y1R) signalling has been shown to play a key role in bone homeostasis, emerging as a novel therapeutic target in bone diseases. Y1R knockout mice (Y1−/−) display a high-bone mass phenotype that has been mainly attributed to increased osteoblast activity. Nevertheless, the Y1R regulatory role on osteoclastogenesis and matrix resorption remains largely unknown. To clarify th...
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ba0006p005 | (1) | ICCBH2017

Muscular fitness, bone mineral density and hip geometry in young males: the PRO-BONE study

Ubago-Guisado Esther , Vlachopoulos Dimitris , de Moraes Augusto Cesar , Torres-Costoso Ana , Wilkinson Kelly , Metcalf Brad , Sanchez-Sanchez Javier , Gallardo Leonor , Gracia-Marco Luis

Objective: The main aim was to evaluate associations between muscular fitness indices and bone outcomes, including hip geometry estimates in young males.Methods: One hundred twenty one males (13.1±0.1 years) were included: 41 swimmers, 37 footballers, 29 cyclists and 14 non-athletes. Lean mass, areal bone mineral density (aBMD) and hip structural estimates were measured using dual-energy X-ray absorptiometry. Relationships of physical fitness tests ...
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Bone Abstracts
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