Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

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ba0005p74 | Bone development/growth and fracture repair | ECTS2016

In vitro investigation of the effect of Magnetic Resonance guided Focused Ultrasound Surgery on osteosarcoma cell lines

Agnese Valentina , Costa Viviana , Carina Valeria , Bellavia Daniele , Raimondi Lavinia , De Luca Angela , Scoarughi Gianluca , Midiri Massimo , Stassi Giorgio , Giavaresi Gianluca

Aim: Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) is an invasive treatment able to control local disease and pain of bone tumors. Unfortunately, there is not any scientific evidence of the biological effect of MRgFUS treatment on tumor cells, especially in lower dose region, where tissues are only warmed to sub-lethal temperatures. Here we investigate the effect of in vitro MRgFUS treatment, at different levels of acoustic energy (200–630 J), on ...
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ba0005p244 | Genetics and Epigenetics | ECTS2016

NBAS is the gene mutated in two patients affected by Acrofrontofacionasal Dysostosis type 1

Palagano Eleonora , Zuccarini Giulia , Mantero Stefano , Conte Daniele , Angius Andrea , Uva Paolo , Prontera Paolo , Vezzoni Paolo , Villa Anna , Merlo Giorgio , Sobacchi Cristina

Acrofrontofacionasal Dysostosis type 1 (AFFND1) is a rare human syndrome (estimated prevalence lower than 1:1,000,000), characterized by bone abnormalities in addition to other multiple congenital anomalies and intellectual disability. Only four AFFND1 families, three of Brazilian and one of Indian origin, have been described so far and an autosomal recessive pattern of inheritance has been suggested. The patients are severely affected: the main clinical features are intellect...
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ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...
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ba0003pp314 | Osteoporosis: treatment | ECTS2014

The effect of risedronate on hypogonadal osteoporotic HIV males treated with highly active anti-retroviral therapy: a pilot study

Pepe Jessica , Isidori Andrea M , Falciano Mario , Iaiani Giancarlo , Salotti Alessandra , Diacinti Daniele , Del Fiacco Romano , Sbardella Emilia , Cipriani Cristiana , Piemonte Sara , Raimo Orlando , D'angelo Antonella , Romagnoli Elisabetta , Lenzi Andrea , Minisola Salvatore

Objective: We evaluated the effect of risedronate on BMD and bone turnover markers in HIV infected osteoporotic males, according to their gonadal status.Methods: 41 HIV patients treated with highly active anti-retroviral therapy (HAART) were followed for 24 months and divided into two groups: patients with osteoporosis or osteopenia with fractures (Group A, n=20) and those without (Group B, n=21). Group A and B were fur...
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ba0003pp126 | Cell biology: osteoblasts and bone formation | ECTS2014

Glucose-dependent insulinotropic polypeptide directly affects collagen deposition and maturation in osteoblast cultures

Mabilleau Guillaume , Mieczkowska Aleksandra , Chappard Daniel

Objectives: A role for glucose-dependent insulinotropic polypeptide (GIP) in controlling extracellular bone matrix deposition and maturation has previously been evidenced in GIP receptor knock-out mice. However, as the GIP receptor is expressed in several tissues other than bone it was difficult to ascertain whether the modifications of extracellular bone matrix were due to direct effects on osteoblasts or indirect through regulation of signals originating from other tissues. ...
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ba0006p019 | (1) | ICCBH2017

Zebrafish as model organism for craniosynostosis

Bluemel Rabea , Klopocki Eva , Liedtke Daniel

Objectives: Craniosynostosis is a skeletal birth defect, resulting in premature fusion of cranial sutures. The patency of the sutures is essential to enable the growth of the skull in compliance to the developing brain. Mutations in TWIST1 and TCF12 have been identified in patients with Saethre-Chotzen syndrome, which is typically associated with coronal synostosis. Studies in mouse models suggest that the quantity of TCF12-TWIST1 heterodimers is one critical...
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ba0004p160 | (1) | ICCBH2015

Prevalence of muscle deficits in survivors of childhood acute lymphoblastic leukemia

Veilleux Louis-Nicolas , Rauch Frank , Curnier Daniel , Krajinovic Maja , Laverdiere Caroline , Sinnett Daniel , Alos Nathalie

Overall cure rates for childhood acute lymphoblastic leukemia (ALL) have improved allowing the cure of over 85% of patients. At least 70% of survivors of childhood ALL cancers have substantial morbidities as a result of their treatment. There is evidence that survivors of ALL have increased rates of long-term skeletal muscle dysfunction and weakness. Our objective was to determine the percentage of patients with muscle dysfunctions (muscle force, power, endurance, and % of fit...
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ba0001pp440 | Osteoporosis: treatment | ECTS2013

Strontium potently inhibits mineralisation in bone-forming osteoblast cultures while osteoclast formation from marrow mononuclear cells is moderately reduced

Wornham Daniel , Hajjawi Mark , Orriss Isabel , Arnett Timothy

Strontium ranelate (SrR) is now widely used for the prevention of osteoporotic fractures. The mechanisms by which this occurs, however, remain unclear. We investigated the actions of Sr2+ salts in bone-forming cultures of primary osteoblasts from rat calvariae. Osteoblasts were treated continuously with either SrR or SrCl2 for 14 days. Abundant, discretely mineralised ‘trabecular’ bone structures formed in alizarin red-stained control cultures. ...
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ba0002p115 | (1) | ICCBH2013

Bone mineral density in late adolescence of transsexuals treated with GnRH-analogues in their teens

Klink Daniel , Caris Martine , van Trotsenburg Mick , Rotteveel Joost

Young transsexuals at a minimum age of 12 years are treated with GnRH-analogues (GnRHa) to suspend pubertal development until the addition of hormones of the desired sex is started at a minimum age of 16 years. The effect of this treatment on adult bone mineral density (BMD) is still unknown. We aimed to assess BMD at the age of 22, as this is near its peak in healthy individuals.In this prospective observational study 19 female to male (FtM) and 16 male...
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ba0003pp24 | Bone biomechanics and quality | ECTS2014

Beneficial effects of a GIP mimetic on bone material properties

Mabilleau Guillaume , Mieczkowska Aleksandra , Irwin Nigel , Flatt Peter , Chappard Daniel

Objectives: A role for glucose-dependent insulinotropic polypeptide (GIP) in controlling bone mass and strength has previously been reported. However, the rapid degradation of GIP in the bloodstream by the dipeptidyl peptidase-4 enzyme precludes therapeutic use. To circumvent this problem, a series of N-terminally modified GIP agonists have been developed. The aim of the present study was to investigate the effects of 28-day treatment with N-AcGIP on bone microarchitecture and...
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Bone Abstracts
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