Bone Abstracts

Objective: The postmenopausal women and elderly men have a big burden for osteoporosis related vertebral fracture and the frequency of clinically unrecognized vertebral fracture is known to be increasing. Vertebral Fracture Assessment (VFA) using DXA is a convenient and safe method to patients together with bone density test and is reported to be proper as a screening method to prevent additional vertebral fracture as diagnosing the vertebral fracture with unrecognized symptom...

Objectives: AIS is a prevalent three-dimensional spinal deformity associated with low bone mass which has been reported to be a significant prognostic factor for curve progression in AIS. If left untreated, low bone mass in AIS could persist into adulthood thus leading to subsequent health problems. This study aimed at evaluating the therapeutic effect of oral calcium plus Vit-D supplementation for low bone mass in skeletally immature AIS girls.Methods: ...

Objectives: Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional spinal deformity associated with low bone mass. Our previous clinical trial demonstrated the anabolic bone effect of vibration treatment (VT) at the femoral neck in AIS subjects. The therapeutic effect was more pronounced in those with optimal serum 25(OH) Vit-D level (>40 nmol/l). To investigate possible factor interaction between Vit-D and VT on their anabolic bone effects, this in-vitro...

Objectives: This study aimed to evaluate detailed bone profiles during puberty for Chinese adolescents in Hong Kong using high-resolution peripheral quantitative computed tomography (HR-pQCT) and dual-energy x-ray absorptiometry (DXA).Methods: 333 healthy girls and 231 healthy boys (12–16-years-old) were recruited from secondary schools. Areal bone mineral density (aBMD) of bilateral femoral necks were measured by DXA while bone quality parameters w...

Engulfment adaptor phosphotyrosine-binding (PTB) domain containing 1 (GULP1) is an adaptor protein involved in the engulfment of apoptotic cells via phagocytosis. Although GULP1 is widely expressed in various tissues, including the brain, muscle, testis, and bone, the function of GULP1 has not been well studied. Here, we investigated whether GULP1 plays a role in the regulation of bone remodeling and examined its expression in bone cells. Conditional Gulp1 floxed mice...

A osteoporotic fracture has become a global health issue that causes tremendous impact on mortality as well as heavy socioeconomic burden. Previous studies suggested that vitamin D may prevent fractures by improving muscle mass as well as via increasing bone density directly. The purpose of the study is to determine that the influence of vitamin D on bone mineral density depends on its effects on muscle mass.We analyzed the data from Korean National Heal...

Although EGF has been known to inhibit osteoblast differentiation, its molecular mechanism has not been clearly elucidated. Smurf1 acts as a negative regulator of BMP signaling by inducing ubiquitination and proteasomal degradation of BMP type I receptor and R-Smads. In this study, we investigated the effect of EGF on the expression of Smurf1 and the role of Smurf1 in EGF-induced inhibition of BMP2-induced osteogenesis. EGF increased Smurf1 expression which was blocked by trea...

Bones’ fracture resistance is achieved in vivo by adaptation to habitual loading. Aged bone can adapt to exercise1 but in female rodents ageing impairs the adaptive response to artificial loading2,3. This inconsistency led us to investigate whether treadmill exercise, sufficiently mild to not itself stimulate new bone formation, could rescue aged bone’s diminished response to artificial loading.Young adult 17-week...

Purpose: Osteoradionecrosis (ORN) of the mandible is a serious complication of radiation therapy, and preceded by soft tissue damage before bone loss appears. However, there is still no adequate treatment to heal the soft tissue damage of ORN. This study investigated the effect of PDGF-BB or mesenchymal stem cells (rMSCs) on radiation-induced soft tissue injury.Methods: Rat model was designed to irradiate the skin of SD rats while sparing the body and in...

Objectives: Metabolic bone disease is a frequent complication of end-stage renal disease, characterised by a decreased bone mineral density, which can be measured with dual-energy X-ray absorptiometry. Its validity as a marker for clinical bone disease and increased fracture risk has never been established in adults with pediatric onset of end-stage renal disease (1–3). Adult survivors of pediatric end stage renal disease have very low bone mineral density and small statu...