Bone Abstracts

Interleukin-6 (IL-6) plays an important role in bone metabolism and regulates fracture healing in a presently unknown process. In the fracture callus IL-6 expression is biphasic; it peaks during the inflammatory phase and again during intramembranous and endochondral ossification (Ai-Aql et al. 2008). Few studies using IL-6 knockout mice indicate that IL-6 might be crucial for bone healing (Yang et al. 2007). However, a generalized IL-6 knockout induces multi...

We have previously shown that female neuronal nitric oxide synthase knockout (nNOS KO) mice have increased trabecular bone volume. However, this study was performed in mice at 10 weeks of age only. To investigate whether the high bone volume is maintained during ageing, we compared 3-month- and 12-month-old wild type (WT) and nNOS KO mice using μCT. The tibias from 8 WT and 8 nNOS KO mice at each age were dissected, fixed for 24 h in buffered formalin, stored in 70% ethan...

: Osteonecrosis of the jaws (ONJ) is a relatively new adverse effect associated with bisphosphonate therapy, but no causal association has been established. By definition, a patient is considered to suffer from ONJ if he has current or previous treatment with a bisphosphonate, exposed bone in the maxillofacial region that has persisted for more than 8 weeks and no history of radiation therapy to the jaws. It has been proposed that ONJ could be linked with impaired topical immu...

The aim of the study was to evaluate effects of 6-month-long administration with nanopartical calcium on morphological and densitometric properties of axial skeleton in pigs subjected to osteoporosis induction with dexamethasone. Male newborn piglets (N=28) were divided after birth into four equal groups (control group receiving placebo, Dex group receiving dexamethasone, NanoCa group receiving orally nanopartical calcium and NanoCa/Dex group) receiving simultaneously...

The aim of this study was to determine morphological and densitometric parameters of mandible obtained from male and female silver foxes (Vulpes vulpes). The study was performed on 1-year-old males (n=7) and females (n=8). Mandible was isolated and subjected to morphological and densitometric analysis using quantitative computed tomography (QCT) method and Somatom Emotion Siemens apparatus (Siemens, Erlangen, Germany) equipped with Somaris/5 VB10B so...

Recent studies suggest the link between low vitamin D levels and the prevalence of cardiovascular disease, diabetes, hypertension and a number of different types of cancer. Nowadays, vitamin D deficiency is recognized as a pandemic health problem and pediatric cancer patients may be even at higher risk than the healthy children. Children suffered from malignancy are especially exposed to its deficiency, because of the potential impact of the disease and its treatment. However,...

Background: Mutations in SATB2 have been described in association with a unique phenotype known as SATB2-associated syndrome (SAS). This condition is characterised by severe intellectual disability affecting speech development, behaviour, facial features and dental anomalies. Skeletal features and osteoporosis have been reported in older individuals (aged 15–36), in association with point mutations. We report a 24-year-old man with a SATB2 misse...

Introduction: Whilst it is well-established that sedentary behaviour may increase the risk of paediatric obesity, and potentially result in early onset cardio-metabolic diseases such as type 2 diabetes and cardiovascular disease, there is less consensus about the potential detrimental effects that long-term sedentary behaviour may have on bone health during childhood.Purpose: To determine if long-term sedentary behaviour affects accrual of bone mass, str...

Objectives: Patients with anorexia nervosa (AN) are at high risk of reduced bone mass. The aim of this intervention study was to investigate the long-term effects on bone and body composition three years after intense weight gain therapy.Methods: Twenty-five female AN patients, mean age 20.1 years, mean BMI of 15.5 kg/m2, were included. Twenty-two patients fulfilled the treatment for 12 weeks with a high-energy diet. Body composition and bone ...

Introduction: The clinical diagnosis of mild forms of hypophosphatasia [HPP], a rare genetic bone disease, is often made in adulthood, on the basis of persistently low serum levels of alkaline phosphatase [ALP], often coupled with signs of poor bone/teeth mineralization.Case report: A 50-year-old male on treatment with vitamin D supplementation because of osteoporosis of lumbar spine (T-score –3.2) and femoral neck (T-score –2.4), was referred ...