Bone Abstracts

Introduction: To analyze clinical assessment and efficacy of once-yearly i.v. zoledronic acid for osteoporosis.Materials and methods: The subjects were 322 osteoporotic patients who received more than single infusion of zoledronic acid in our hospital from October 2008 to March 2011. On clinical assessment, the adherence was evaluated by measuring the rate of reinfusion. Adverse events were recorded for safety assessment. For efficacy assessment, the bon...

Objective: The aim of this study was to assess the relationship between renal function (estimated glomerular filtration rate (eGFR) using Cockcroft–Gault (CG) equation and modification of diet in renal disease (MDRD), respectively), bone mineral density (BMD) and both arterial stiffness in Korean postmenopausal women.Materials and methods: From January 2008 until December 2010, among the person who got medical examinations including bone densitometr...

Purpose: Osteoradionecrosis (ORN) of the mandible is a serious complication of radiation therapy, and preceded by soft tissue damage before bone loss appears. However, there is still no adequate treatment to heal the soft tissue damage of ORN. This study investigated the effect of PDGF-BB or mesenchymal stem cells (rMSCs) on radiation-induced soft tissue injury.Methods: Rat model was designed to irradiate the skin of SD rats while sparing the body and in...

Objectives: Metabolic bone disease is a frequent complication of end-stage renal disease, characterised by a decreased bone mineral density, which can be measured with dual-energy X-ray absorptiometry. Its validity as a marker for clinical bone disease and increased fracture risk has never been established in adults with pediatric onset of end-stage renal disease (1–3). Adult survivors of pediatric end stage renal disease have very low bone mineral density and small statu...

The receptor activator of NF-kB (RANK) and ITAM-containing adaptors have been identified as essential factors involved in osteoclast formation and bone remodeling, but their mechanisms and interacting factors have not yet been fully identified. Here we report that early estrogen-induced gene 1 (EEIG1), a novel RANK ligand (RANKL)-inducible protein, physically interacts with RANK and further associates with Gab2, PLCg2, and Tec/Btk kinases by RANKL stimulation. Overexpression o...

Tyrosine kinase c-Src plays an important role in actin ring formation and bone resorption activity in osteoclasts. Therefore, c-Src has been targeted for the treatment of osteolytic disorders. In the present study, we investigated anti-resorptive effect of dibenzazepine (DBZ), one of the γ-secretase inhibitors (GSIs), on osteoclast-mediated excessive bone resorption. DBZ did not affect osteoclast differentiation, but disturbed actin ring formation and inhibited osteoclast...

Objectives: We investigated bone mineral density (BMD) in women as this is related to a history of previous pregnancies and miscarriage and according to age.Materials and methods: We performed retrospective study on 1043 women who had their BMD in a university hospital. We analyzed the BMD and the previous obstetric history according to age and the clinical characteristics.Results: The mean age of the study subjects was 56.7±5...

Melatonin is a neuro-hormone released primarily from the pineal gland, which has been shown to have bone anabolic effect, although it is still unclear whether its skeletal action is directly mediated by receptors expressed on bone cells or is indirect. In this study, we examined melatonin’s effects on bone cellular activities in vitro and tested whether it modifies angiogenesis and blood flow to bone, which are both essential for bone formation.<p class="abst...

Notch signaling plays a central role in various cell fate decisions, including skeletal development. Recently, Notch signaling was implicated in osteoclast differentiation and maturation, including the resorption activity of osteoclasts. However, the specific involvement of notch signaling in resorption activity was not fully investigated. Here, we investigated the roles of Notch signaling in the resorption activity of osteoclasts by use of the γ-secretase inhibitor diben...

Introduction: Hypertrophy of ligamentum flavum (LF) induces narrowing of spinal canal which develops neurogenic claudication. Several mechanisms of LF hypertrophy have been suggested. Among them inflammatory cytokine play a crucial role in LF hypertrophy by increasing collagen synthesis. Cyclooxygenase-2 (COX-2) pathway shares inflammatory reaction from infection and arthritis. Selective COX-2 inhibitor (COX-2si) might modulates collagen synthesis via suppressing inflammatory ...