Bone Abstracts

It has long been known that osteoarthritis induces dramatic structural changes in subchondral bone. Studies on patients’ biopsies have also shown that the new sclerotic bone is hypomineralized and has decreased elastic modulus. Due to their amenability for genetic studies, murine models of OA are particularly important for drug target discovery. However, whilst osteosclerosis has been reported also in murine OA models, little is known about the compositional and mechanica...

Introduction: We recently showed that patients with primary Sjögren Syndrome (pSS) have significantly higher bone mineral density (BMD) in the lumbar spine and femoral neck compared with healthy controls. The majority of those patients (69%) were using hydroxychloroquine (HCQ), which may have favourable effects on BMD.Aim: To evaluate whether HCQ modulates human bone cells in vitro.Methods: Osteoblasts were differenti...

Objective: Autism Spectrum Disorder (ASD) is associated with lower bone mass in children. Physical activity and nutrition influence bone pathophysiology, and differences in these lifestyle factors are observed between children with vs. without ASD; however, whether these factors contribute to bone differences is unknown. We examined if: 1) differences existed in bone mineral density (BMD), content (BMC), or bone geometry in boys with vs without ASD and 2) whether physical acti...

Background: Rickets is a disorder of the growing child arising from impaired mineralisation of the growth plate and osteoid. The most common cause of NR in the UK is thought to be secondary to vitamin D deficiency [VDD; serum 25-hydroxyvitamin D (25OHD) <25 nmol/l], although in some African & South Asian countries dietary calcium deficiency (DCaD) by itself, or together with VDD is an important cause of NR (Ann Trop Paediatr. 2006;26:1–16). Currently, the data on ...

Vertebral fractures (VF) defined by morphometric analysis of spine radiographs are the most common complication of osteoporosis. Those that come to medical attention, with symptoms such as back pain and kyphosis are termed clinical vertebral fractures (CVF) and account for significant morbidity and mortality. Although much progress was made in identifying loci for bone mineral density, the genetic determinants of CVF remain unclear. Here we present the initial results from a g...

Introduction: Parathyroid hormone (PTH) measurement is of use in i) differential diagnosis of hypercalcaemia and ii) patients with renal impairment at risk of bone disease. PTH immunoassays are complicated by cross-reactivity with truncated (inactive) variant forms, which accumulate in patients with renal impairment. PTH assay variability is a critical governance issue in renal medicine, suggesting an MS-based reference method is required.Aim: To develop...

Objective: To determine serum 25-lydroxivitamin D (25OHD) and intact parathyroid hormone (PTH) levels in an immobilized population from Northern Spain.Subjects and methods: We studied 125 immobilized people (37 men and 88 women) aged 53–101 years. (85±8 years.). Seventy-five percent of the subjects lived at home, residing in nursing homes the remaining 25%. None of them received antiresorptive therapy, corticosteroids or vitamin D supplements. ...

Objective: To analyze the effects of statins on bone mineral density (BMD), in participants from a large population-based cohort.Subjects and methods: We studied 2315 subjects (1422 women and 893 men) from the Camargo Cohort, and analyzed the differences in BMD between statin or non-statin users. We also studied the effect of the type of statin, dose, pharmacokinetic properties, and length of treatment, on BMD.Results: Four hundred...

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The regions of the proximal femur that are at greater risk of structural failure during a fall are those with less adaptive protection promoted by mechanical loading of the activities of daily living. Considering the associations between bone geometry of the proximal femur with bone fracture risk, we intended to examine how geometrical characteristics of the proximal femur (FNL, femoral neck length; FNW, femoral neck width; NSA, neck shaft angle) moderate the effect of mechani...