Bone Abstracts

Pathologist Christian Georg Schmorl described a specific type of vertebral lesion, which is now known as Schmorl’s node. A Schmorl’s node or intradiscal herniation is herniation of nucleus pulposus through the cartilaginous and bony end plate into the body of an adjacent vertebra. Schmorl nodes are seen primarily in the thoracolumbar spines in an elderly population. Schmorl nodes are associated with moderate but not advanced degenerative changes. An 11-year-male pres...

Objectives: To determine the prevalence and intensity of D-deficiency in children and adolescents in the metropolitan area with subtotal deficiency of ultraviolet B (55° N).Methods: From May 2008 to May 2010 in a random sample of 163 Muscovites 0–18 years old (9.9±0.4; girls/boys, 81/82) serum 25-hydroxyvitamin D content was determined by chemiluminescent analysis (DiaSorin, Inc., USA; n=56 and Roche Diagnostics; n=107). ...

Evidence is unclear on the effect of vitamin D intake on vitamin D status in children.Objective: In a meta-analysis, investigate the effect of vitamin D supplements and/or fortified foods on vitamin D status, using the biomarker 25-hydroxyvitamin D (25(OH)D) in children 2–18 years.Methods: Eligible studies were randomized placebo-controlled trials, published in English, in children 2–18 years that compared vitamin D suppl...

Vitamin D and its metabolites are bound to vitamin D binding protein (DBP) in the circulation. Only a small proportion is in unbound, free form. According to the ‘free-hormone-hypothesis’ only the free form is biologically active. DBP is a polymorphic protein and different variants of the protein differ in their ability to bind vitamin D. This may have an impact on the amount of free and bioavailable (free+albumin-bound) 25-hydroxyvitamin D (25(OH)D) in the circulati...

Objectives: To assess the effects of short-term vitamin D supplementation on bone metabolism, glycaemic status and immune function in vitamin D deficient children.Method: Treatment with daily 5000 IU cholecalciferol supplementation for 6 weeks. At baseline and end of treatment serum 25 hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), alkaline phosphatase (ALP), serum collagen type 1 cross-linked C-telopeptide (CTX), serum calcium, HbA1c, sex hormon...

Introduction and aims: Deficiency of vitamin D has been reported in subjects with many types of musculoskeletal pain. The aim of the present study was to determine the association between serum 25-hydroxyvitamin D (25(OH)D) and nonspecific skeletal pain in healthy Saudi women.Methods: Serum 25(OH)D were measured for 223 healthy women with nonspecific skeletal pain at different regions of the skeletal system including back pain. Serum 25(OH)D was measured...

Introduction: Vitamin D is an essential material in bone metabolism, and regulation of body minerals. Vitamin D deficiency has various causes, including limitations in sunlight exposure (type of clothing, sunscreen usage, indoor activity), seasonal geographic latitude and altitude, atmospheric pollution, diet, and ageing.The aim of the work was to determine the frequency of vitamin D deficiency among Ukrainian schoolchildren and its influence on bone min...

Background: Improving the general population’s vitamin D status through food fortification is part of an ongoing debate. Vitamin D status during pregnancy may influence the long-term bone health of offspring; yet conflicting results have been reported and none of the studies have examined paediatric fracture as outcome.Method: The influence of extra vitamin D exposure during prenatal life and risk of fracture during adolescence was determined by com...

Objective: To analyse the influential factors of lifestyle on vitamin D status among aged people in Shanghai community.Method: Lifestyles of 3846 elderly men and women aged over 65 years were investigated using a self-designed questionnaire from ten communities of urban and suburb in Shanghai China, which contained sociodemographic factors and lifestyle factors and so on. The levels of serum 25(OH)D were measured by Cobas Diagnosis System of Roche. Univa...

Suppression of parathyroid hormone (PTH) has been suggested as a potential biochemical outcome measure for determining the optimal serum 25-hydroxyvitamin D (S25(OH)D) concentration for bone health in adults. However, in adolescents increases in PTH may not be driven by the same mechanisms and may not be detrimental to bone health. Adolescent studies have provided a wide range of estimates of the S25(OH)D concentration at which PTH plateaus (40–90 nmol/l), with some repor...