Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

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ba0005p395 | Osteoporosis: treatment | ECTS2016

Acute kidney injury after a single intravenous zoledronic acid administration in patients with osteoporosis

Cipriani Cristiana , Clementelli Carolina , Fassino Valeria , Manai Rizieri , Danese Vittoria , Cecchetti Veronica , Ferrone Federica , Pepe Jessica , Minisola Salvatore

Safety data on zoledronic acid (ZA) administration for osteoporosis suggest potential kidney toxicity; indeed, it is not indicated in patients with impaired renal function. Patients’ clinical monitoring usually includes glomerular filtration rate (GFR) evaluation; no study addressed the issue of the early kidney injury. We evaluated the early (within 3 months) effect of iv ZA on renal function defining the potential role of AKI biomarkers in unveiling subtle damage.<p...
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ba0006oc13 | (1) | ICCBH2017

Enterococccus faecium abundance in gut microbiome is associated with higher bone mineral density in school age children

Medina-Gomez Carolina , Radjabzadeh Djawad , Boer Cindy G. , Van Meurs Joyce , Kraaij Robert , Uitterlinden Andre G , Rivadeneira Fernando

Aim: Human gut microbiota is an important determinant of health and disease. Discoveries from recent microbiome studies have been postulated as actionable targets to treat malnutrition, diabetes, obesity among other conditions. The role of the gut microbiome on the development of the human musculoskeletal system is yet to be established. The aim of our study was to investigate the association between bacterial operational taxonomic units (OTUs) of the gut in relation to bone m...
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ba0006oc15 | (1) | ICCBH2017

Fractures in school age children in relation to sex, ethnic background and bone mineral density: the generation R Study

Grgic Olja , Medina-Gomez Carolina , Trajanoska Katerina , Shevroja Enisa , Koromani Fjorda , Uitterlinden Andre , Jaddoe Vincent , Wolvius Eppo , Rivadeneira Fernando

Objectives: Previous studies indicate that about half of boys and one fourth of girls suffer a fracture before the age of 16 years. Similarly, children of European descent are more prone to fracture. Here we aimed to investigate at the population level the influence of sex, ethnic background and bone mineral density (BMD) on the occurrence of bone fractures in children of school age.Methods: This study (n=3,633 children with complete information...
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ba0006p015 | (1) | ICCBH2017

Structural geometry of bones is prominently associated with risk of fracture in children

Medina-Gomez Carolina , Grgic Olja , Shevroja Enisa , Trajanoska Katerina , Uitterlinden Andre G , Jaddoe Vincent W , Beck Tom J , Rivadeneira Fernando

Background: Low total body BMD (TB-BMD) is an established risk factor for fractures in healthy children. However, bone strength depends not only on bone mass and density, but also on the structural geometry of bones. Hip structural analysis (HSA) is a technique applied on hip DXA scans to calculate several bone geometry parameters. The aim of our study was to evaluate other bone geometrical parameters that can constitute determinants of fracture risk. Specifically, we examined...
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ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...
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ba0003pp319 | Osteoporosis: treatment | ECTS2014

Perceived vs objective knowledge in patients with osteoporosis

Miller Amanda , Thompson Kara , Cole Jenneth , Kaiser Stephanie

Previous studies have demonstrated that patients with osteoporosis (OP) have a poor understanding of their bone disease and that this negatively influences treatment decisions and medication compliance. The aim of this study is to determine if there is a discrepancy between perceived and objective disease knowledge (PK and OK, respectively) in patients with OP and whether this correlates with certain patient characteristics.Design and methods: After ethi...
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ba0001op29 | Pre-Clinical | ECTS2013

miR-192 impairs invasion and tumor-induced osteolysis by repressing CCL2 in bone metastatic colonization

Valencia Karmele , Luis-Ravelo Diego , Bovy Nicolas , Martinez-Canarias Susana , Ormazabal Cristina , Zandueta Carolina , Anton Iker , Struman Ingrid , Tabruyn Sebastien , Segura Victor , De Las Rivas Javier , Bandres Eva

see PP154....
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ba0001pp154 | Cancer and bone: basic, translational and clinical | ECTS2013

miR-192 impairs invasion and tumor-induced osteolysis by repressing CCL2 in bone metastatic colonization

Valencia Karmele , Luis-Ravelo Diego , Bovy Nicolas , Martinez-Canarias Susana , Ormazabal Cristina , Zandueta Carolina , Anton Iker , Struman Ingrid , Tabruyn Sebastien , Segura Victor , De Las Rivas Javier , Bandres Eva

Emerging evidence suggests that miRNAs (miR) can modulate a complex gene network in a cell-intrinsic and non-cell autonomous manner. We previously identified by transcriptomic analysis miR-192 to be heavily downregulated in different highly metastatic subpopulations (HMS) isolated from bone metastases in a lung cancer mice model, but its mechanistic contribution to the prometastatic activity remains unknown.To delineate the pleiotropic functions elicited...
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ba0001pp484 | Other diseases of bone and mineral metabolism | ECTS2013

Osteocyte metabolism on post-menopausal bone loss and role of hormone replacement therapy

Silva Ana Maria , Moreira Ana Carolina , Santos Maria Sancha , Albuquerque Anabela , Ferreira Izilda , Gil Paulo , Isidoro Jorge , Videira Romeu , Carvalho Rui , Sardao Vilma

Introduction: Osteocytes play a major role in the bone remodelling unit (BRU). Thus, we hypothesize that mitochondrial bioenergetics impairment and mitochondrial/peroxisomal fatty acid β-oxidation unbalance is a cause of osteocytes metabolic decline during 17β-estradiol (E2) reduction. E2 and a phytochemical substitute, coumestrol (COU) were used (30 mg/kg during 24 h in ovariectomized rats in order to compare bone loss with sham-operated animal...
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ba0002oc7 | Biology | ICCBH2013

The PPP6R3/LRP5 locus influences lean mass in children of different ethnic background and highlights pleiotropic effects and muscle–bone interactions

Medina-Gomez Carolina , Heppe Denise , Estrada Karol , Hofman Albert , Hsu Yi-Hsiang , Karasik David , Jaddoe Vincent , Zillikens M Carola , Uitterlinden Andre G , Rivadeneira Fernando

Aim: Lean and bone mass have considerably high phenotypic and genetic correlations with a shared heritability estimate ranging between 30 and 40% in adults. A genome-wide association study (GWAS) on total body lean mass and a bivariate GWAS on lean mass and BMD were ran in a cohort of children to identify genes with pleiotropic effects on muscle mass and peak bone mass attainment.Methods: Subjects are part of the Generation R study, a prospective multiet...
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Bone Abstracts
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