Bone Abstracts

Paget’s disease of bone is a condition where the process of bone remodeling is disrupted; Its primary event is an increased bone resorption followed by a subsequent reactive bone formation. The disease is most common in central Europe, the United Kingdom, Australia, and New Zealand. It is also found, though with lower incidence, in southern Europe, Scandinavia, and the United States. It is extremely rare in East Asian countries, especially in Korea, Japan, China, the Midd...

Objective: The use of high-impact weight bearing physical activities has been accepted as a means to increase osteogenic effects on bone. Studies in adolescents found that physical activity could counteract the detrimental effects on bone associated with television time in boys and time spent studying in girls. Our aim was to test the effects of the percent of time spent in moderate plus vigorous activities (ModVig) and sitting (SIT) on bone health. We hypothesized that high M...

Introduction: Most reports focused on clinical advantages of intervertebral cages; only a few studies reviewed the complications. As one of the major complications, cage migrating into vertebral body or spinal canal may result in disastrous consequence. Multiple risk factors may result in cage migration, such as geometric design of cage, surgical technique, the bone quality and post-operative protection. The following is a presentation of nine patients with migrated cage.<...

Background and objectives: Vitamin D deficiency causes calcium-depleted bone, which further weakens the bones and increases the risk of fractures. Also, It is known as related to obstetrics problem like gestational diabetes, infections, preeclampsia and incidence of caesarean section as well as glucose metabolism, immune system, cardiovascular diseases and cancer.Recently, the relationship between preterm birth and vitamin D deficiency becomes the main i...

Limb length discrepancy has been observed in children with hemiplegic cerebral palsy (HCP). However, the difference of bone age and limb lengths have been a controversial issue. The purpose of this study was to analyze the bone age and the upper extremity segmental lengths between affected and naffected in HCP patients.Seventy-eight patients (39 boys and 39 girls; mean age 71.3±28.1 months). Fourty-five children were right and 33 were left hemiplegi...

Introduction: It has been reported that low bone mass is common in patients with pulmonary disorders such as chronic obstructive pulmonary disease. However, in healthy non-smoking women, the relationship between bone mass and pulmonary function has yet to be clarified. The object of this study was to determine whether pulmonary function is related to BMD in healthy non-smoking women based on menopausal status.Methods: This study was a cross-sectional stu...

Objectives: To examine the association of gastrointestinal (GI) events and osteoporosis (OP) therapy initiation patterns among postmenopausal women following a diagnosis of OP from a large health plan in Israel.Methods: Women aged ≥55 years were included in the analysis if they had ≥1 OP diagnosis (ICD-9 733.0X) (date for first OP diagnosis was index date), no estrogen use, no diagnosis of Paget’s disease or malignant neoplasm. OP treatm...

Objective: To estimate the proportion of patients who experienced cardiovascular (CV) events or were at risk for CV events prior to initiation of strontium ranelate among osteoporotic (OP) patients.Methods: This was a retrospective database analysis using the Clinical Practice Research Datalink (CPRD) database. Patients were included if they had ≥1 prescription (Rx) of strontium from 9/1/2008 to 8/31/2013, were aged ≥50 years as of the index ...

Introduction: Children with chronic kidney disease (CKD) who suffer from growth retardation have usually normal circulating GH but low IGF1, suggesting GH resistance. We have previously shown in growth retarded CKD rats an increase in suppressor of cytokine signaling 2 (SOCS2) levels, a key negative regulator of GH signaling. SOCS2 spontaneously mutated (HG) mice show an exaggerated body growth and increased bone mass. We investigated growth and GH receptor (GHR) signaling in ...

Periosteum contains mesenchymal progenitors and is essential for fracture healing. Signaling mechanisms governing periosteal reaction to injury remain largely unidentified. We previously investigated how PI3 kinase signaling affects the skeletal system using CblYF/YF knock-in (YF) mice wherein PI3K signaling is perturbed by abolition of interaction between Cbl, an E3 ubiquitin-ligase/adaptor protein, and p85 subunit of PI3K. YF mice displayed increased bone volume u...