Bone Abstracts

Suppression of parathyroid hormone (PTH) has been suggested as a potential biochemical outcome measure for determining the optimal serum 25-hydroxyvitamin D (S25(OH)D) concentration for bone health in adults. However, in adolescents increases in PTH may not be driven by the same mechanisms and may not be detrimental to bone health. Adolescent studies have provided a wide range of estimates of the S25(OH)D concentration at which PTH plateaus (40–90 nmol/l), with some repor...

Background: Sun exposure may be limited in Arctic populations and Greenland Inuit have adapted to the Arctic environment. The influence of chronic low vitamin D level on PTH to uphold a normal serum calcium remains to be elucidated.Objective: To describe the association between PTH and factors known to influence PTH-, including vitamin D (25OHD) and calcium, in Arctic populations.Methods: Inuit and non-Inuit in the capital city Nuu...

Introduction: The effect of vitamin D± calcium supplementation in children has traditionally been assessed using growth parameters, biochemical markers and radiographs.Objectives: To evaluate the utility of Bone Health Index (BHI), obtained using automated hand radiogrammetry, in assessing treatment effect in children participating in a vitamin D supplementation trial.Methods: In this double-blind placebo-controlled trial, Afg...

Recent studies suggest the link between low vitamin D levels and the prevalence of cardiovascular disease, diabetes, hypertension and a number of different types of cancer. Nowadays, vitamin D deficiency is recognized as a pandemic health problem and pediatric cancer patients may be even at higher risk than the healthy children. Children suffered from malignancy are especially exposed to its deficiency, because of the potential impact of the disease and its treatment. However,...

Introduction: Serum 25(OH)D concentrations for optimal bone metabolism in children is unknown. Only few data exist describing the effects of increasing serum 25(OH)D on bone metabolism markers.Aim: The aim of the study was to explore the association between serum 25(OH)D and bone metabolism markers in children.Patients and methods: Serum levels of bone formation (OC, P1NP) and bone resorption (CTx) markers (Cobas e411, Roche Diagno...

Objective: The objective of this observational cross-sectional study is to identify the prevalence of vitamin D deficiency in healthy women in Greece, as reflected by the levels of 25-hydroxyvitamin D (25(OH)D), since recent data indicate that vitamin D deficiency can be common in countries previously considered as low risk (e.g. Mediterranean countries).Materials and methods: A population of 840 community dwelling women was recruited at the health promo...

Recent studies suggest that the concentration and genotype of vitamin D binding protein are important factors that determine the bioavailability of 25OH Vit-D in blood. It has been suggested that measurement of free, non-protein bound 25OH Vit-D in serum, may provide more relevant diagnostic information than total 25OH Vit-D, for instance in chronic kidney disease, bladder cancer and pancreatic cancer, or in hemodialysis patients.To measure free 25OH Vit...

Introduction: Vitamin D deficiency is common in patients with rheumatoid arthritis and may be related to disease activity.The aim of the study was to evaluate the association between 25(OH)D level and disease activity in patients with rheumatoid arthritis.Materials and methods: The study included 61 patients with rheumatoid arthritis, 73.8% were women, 70.4 patients were younger 60 years old. Subjects suffering from liver and kidne...

Background and objectives: Vitamin D deficiency causes calcium-depleted bone, which further weakens the bones and increases the risk of fractures. Also, It is known as related to obstetrics problem like gestational diabetes, infections, preeclampsia and incidence of caesarean section as well as glucose metabolism, immune system, cardiovascular diseases and cancer.Recently, the relationship between preterm birth and vitamin D deficiency becomes the main i...

A osteoporotic fracture has become a global health issue that causes tremendous impact on mortality as well as heavy socioeconomic burden. Previous studies suggested that vitamin D may prevent fractures by improving muscle mass as well as via increasing bone density directly. The purpose of the study is to determine that the influence of vitamin D on bone mineral density depends on its effects on muscle mass.We analyzed the data from Korean National Heal...