Bone Abstracts

see P368....

Low body mass index (BMI) or body weight is a well-known risk factor for osteoporosis and fragility fractures. However, the relative contribution of lean mass and fat mass on bone health, i.e. fragility fractures is inconclusive.We elucidated the relative contribution of lean and fat mass on fracture risk by group analysis in Korean men and women. This was an ongoing prospective community-dwelling cohort study at Ansung in Korea, begun in 2001. We includ...

Multiple Myeloma (MM) is a malignancy of Plasma Cells (PC), characterized by severe osteolytic lesions but poor 99Tc-MDP uptake in bone scans due to osteoblast inhibition. We hypothesized that high demands for membrane biosynthesis in tumour PC would enhance monocarboxylic acid anabolism and uptake, which could be exploited for treatment and molecular imaging. Here, we tested the efficacy of clinically available 11C-Acetate PET to detect myeloma and quant...

Context: As bone metabolic markers, recent studies indicated vitamin D and osteocalcin (OC) were also involved in energy metabolism. While the exact relationship between vitamin D and OC in regulating energy metabolism is unclear. One of the possibilities is that: low vitamin D could lead to secondary hyperparathyroidism and following high bone turnover, which would enhance the quantity of bioactive OC.Objective: Our aim was to study whether OC mediated ...

Introduction: Low-magnitude, high-frequency (LMHF) mechanical stimuli lead to enhance bone formation and decrease resorption. This study aimed to investigate the effect of vibration on the bone loss induced by inflammatory cytokine, lipopolysaccharide (LPS).Methods and designs: Balb-C mice were administered to LPS (5 mg/kg) with two i.p. injections on days 0 and 4, while sham control group was injected with 400 μl of water for injection without LPS....

Purpose: To investigate the effect of enamel matrix derivative (Emdogain) on the attachment, growth behavior and the genetic effect of human gingival fibroblasts (HGF) cultured on zirconium disc surfaces.Materials and methods: HGF cells were cultured on i) zirconium discs without enamel matrix derivative (EMD), ii) zirconium discs with EMD 25 μg/ml, and iii) zirconium discs with EMD 100 μg/ml. The cell proliferation activity was evaluated throu...

Indoxyl sulfate (IS) is one of a number of protein-bound uremic toxins that accumulate in patients with chronic kidney disease. Current conventional hemodialysis is ineffective at removing this toxin. Although IS may impair osteoblast function and induce abnormalities of bone turnover or arthropathy, the effects on knee joint tissue by IS has not been investigated yet. The present studies have been carried out to test the IS effects on synovial fibroblasts, meniscal fibrochond...

Objectives: To find the predicting factors for bone density in premenopausal women.Methods: Two hundred and forty-five premenopausal women without factors that can cause secondary osteoporosis were analyzed. Age, height, weight, change of height from peak height, history (Hx) of fracture, family Hx of hip or other fracture, Hx of estrogen use, calcium or vitamin D supplementation, smoking and previous Hx of amenorrhea more than 3 months were questioned. ...

Introduction: A significant number of patient who have experienced previous surgical treatment for an osteoporotic hip fracture, experienced a subsequent hip fracture (SHF) on the opposite side. The incidence of asynchronous bilateral hip fractures is 1.7–14.8%. All hip fracture patients treated at five university hospitals in the Inchon and Bucheon area of Korea, were reviewed. The patients were divided into two groups, a group that had experienced subsequent hip fractur...

Objectives: To evaluate the effect of hormone therapy on the change of bone mineral density in women who showed early menopause after pelvic radiation therapy for uterine cervical cancer.Materials and methods: Through retrospective chart review, the changes of bone mineral density in 63 women with early menopause after pelvic radiation therapy for uterine cervical cancer were evaluated. After the diagnosis of early menopause which was defined as level of...