Bone Abstracts

Objectives: Single nucleotide polymorphisms (SNP) in genes related to vitamin D metabolism have been associated with 25-hydroxyvitamin D (25(OH)D) status, but these relationships have not been examined in pregnancy or following antenatal vitamin D supplementation. We assessed whether SNPs in DHCR7 (7-dehydrocholesterol reductase), CYP2R1 (25-hydroxylase), CYP24A1 (24-hydroxylase) and GC (Vitamin D binding protein) were associated with the re...

Introduction: Vitamin D deficiency has been associated with impaired physical functioning and several chronic diseases and might thereby affect quality of life and self-rated health. The aim of this study was to assess relationships of serum 25-hydroxyvitamin D (25(OH)D) with quality of life and self-rated health, and to examine whether physical performance and number of chronic diseases mediate these relationships.Methods: Data were obtained from the LA...

The aim of the work was to determine the influence of vitamin D deficiency on bone mineral density in schoolchildren.Methods: There were examined 304 children aged 10–18 years. The boys consisted 55.0%. The average age of boys was 12.9±0.2 and girls – 12.4±0.2 years old. Researches included ultrasound densitometry of calcaneus by SAHARA (Hologic), blood chemistry, 25(OH)D and intact parathyroid hormone (iPTH) in plasma were determined...

Objectives: The linear growth of child is characterized by the presence of phases of growth spurt which allowed to rich the peak growth to the end of puberty. Acceleration of velocity of linear growth required the adequate calcium and vitamin D supplementation necessary for mineralization of bone matrix and osteoblast proliferation.The aim of our study was to evaluate changes of serum concentrations of vitamin D during the growth phases.<p class="abs...

Objectives: Vitamin D deficiency is of current interest especially in high risk patients for reduced bone mineral density as in pediatric hematologic oncologic patients.Methods: During a 4 year period 194 pediatric hematologic oncologic patients were screened for serological vitamin D deficiency (defined as 25 (OH)D levels <30 ng/ml and accordingly <75 nmol/l). 61 patients were in the prospective group 1 defined as screening at time of diagnosis,...

Objectives: Study the prevalence of hypovitaminosis D in chronically ill children in Greece, as well the efficacy of a proposed replacement therapy.Methods: A total number of 213 children (121 males and 92 females), with mean age 10.1 years (1–18), suffering various pathological conditions (cerebral palsy, Duchenne myopathy, epilepsy), were sampled to measure serum 25(OH)D and parameters of bone turnover. 101 children were given replacement therapy ...

Data on the prevalence of vitamin D deficiency/insufficiency in children with haematological malignancies (HM) in Sweden are scarce. Our studies indicate that one third of children with HM had vitamin deficiency/insufficiency already at the time of diagnosis. In this study, we aimed to investigate the impact of season and age at HM onset on vitamin D status by analysing 25(OH)D levels in two different age groups: children ≤6 years of age, and children >6 years of age...

Objectives: 1) To determine the prevalence of Vitamin D deficiency in children with newly diagnosed cancer; 2) Compare Vitamin D levels of children with and without cancer; 3) Evaluate race and sex differences in Vitamin D levels.Methods: IRB approved retrospective review of medical records from our pediatric tertiary care center from 2011–2018. Inclusion criteria were serum 25-OH D within 3 months of oncology diagnosis and other non-oncology diagno...

Objective: Biochemical assessment of teenage patients with adolescent idiopathic scoliosis (AIS).Methods: Blood sampling from 120 patients with AIS aged 12–17 years. The patients all had significant scoliosis and blood samples were taken a few days or weeks before they underwent scoliosis surgery. Serum 25-hydroxy-vitamin D (25-OHD), calcium, phosphate, alkaline phosphatase and parathyroid hormone (PTH) were measured. Patients with a 25-OHD level be...

The skeletal effects and new biological effect of Vitamin D are receiving increased attention. However detection methods in 25-hydroxyvitamin D (25(OH) D) measurement are not standardized and variation between laboratories ahd methods has become attractive. This study emphasizes relativity and consistency between ELISA, ESI-LC-MS/MS and electrochemical luminescence analysis which are used widely in China. This study collected 64 cases of blood, and finally obtained good relati...