Bone Abstracts

Biographical DetailsEleonora Dondossola is a Senior Postdoctoral Fellow in the Intravital Imaging Lab, Koch Center for Applied Research in Genitourinary Cancers, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. She received her PhD in Cell and Molecular Biology from S. Raffaele Vita-Salute University, Milan, Italy, in 2010. Her current research is focused on metastasis...

Hip fractures in children are extremely rare and account for less than 1% of all fractures in children. Most orthopaedic surgeons will treat only a few such fractures in a lifetime. They are associated with high complication rate because the vascular and osseous anatomy of the child’s proximal femur is vulnerable to injury. Knowledge of the blood supply to the immature proximal femoral epiphysis is necessary to adequately manage these injuries. Hip pain in children is a d...

Introduction: Hereditary multiple osteochondromas (HMO) is characterized by the outward growth of cartilage-capped bone tumors. Osteochondromas contain a bone marrow cavity continuous with the normal bone cavity. Because of their off-axis position, osteochondromas are expected to carry less load than normal bone tissue. According to Wolff’s law, we therefore hypothesized that osteochondromas would have a less developed, osteoporotic-like microstructure. To test this hypot...

Childhood cancer has become curable in the majority (>70%) of patients. This is mainly due to rising intensity of treatment, including (combinations of) surgery, chemotherapy, radiotherapy and stem cell transplantation. In addition, intensive international collaboration for rare subgroups, enhanced stratification for treatment regimens and optimised supportive care has contributed to the improved survival of pediatric cancer that was accomplished over the last decades....

According various guidelines the basic recommendation in prevention and treatment of postmenopausal osteoporosis (PMO) is adequate intake of calcium (1000– 1300 mg/day) and vitamin D (800–1000 IU/day).Aim: To determine the intake dose of calcium and also the vitamin D saturation in women treated for PMO.Patients and methods: 465 women with PMO, divided into two groups: patients with newly diagnosed osteoporosis (n</em...

Introduction: Umbilical cord blood (UCB) is increasingly used in hematopoietic stem cell (HSC) transplantations; however, the low cell numbers are still remaining as a limiting factor for proper engraftment. Osteoblasts are major constituents of HSC niche and play important roles in regulating HSC self-renewal and differentiation. Recently, extracellular vesicles (EVs) have been implicated in stem cell fate regulation via horizontal transfer of proteins and nucleic acids betwe...

: This study analyses the long-term effect of rhGH on final height (FH) and bone health in renal transplanted patients.Twenty-one young adult patients, aged 17–26 years, were studied. Group A consisted of 15 patients (12 boys) who received rhGH during 3.0 years before transplantation. After transplantation three boys needed rhGH again for 3.5 years. In group B six patients (three boys) didn’t need rhGH before transplantation, three girls receiv...

Background: Bisphosphonates are widely used to prevent and treat osteoporosis. Limited evidence suggest that these drugs may reduce mortality, perhaps by protecting against cardiovascular disease. This study investigated the occurrence of heart failure in patients treated with bisphosphonates.Methods: Nationwide retrospective cohort study from Denmark. All users of bisphosphonates and raloxifene (n=4.831) between 1996 and 2006 (n=102.34...

Objectives: The ability to discriminate bone fractures that result from non-accidental injuries and those that result from underlying bone fragility is limited by the lack of clinical instrumentation to directly measure bone mechanical properties. The BioDent Hfc (Active Life Scientific) is an experimental device that has been validated for measuring cortical bone fracture resistance in adults. We are currently developing protocols to test the feasibility of its use in infants...

Background and aim: Eight cases of bisphosphonate-associated osteonecrosis of the external auditory canal have been reported in case-reports. Our aim was to describe the incidence of external auditory canal and middle ear diseases in Danish patients exposed to bisphosphonates in the treatment of osteoporosis.Methods: The study was a retrospective, nationwide cohort study, within the Danish population of approximately 5.6 million individuals and based on ...