Searchable abstracts of presentations at key conferences on calcified tissues

ba0002p183 | (1) | ICCBH2013

Juvenile idiopathic osteoporosis: a case study

McDonnell Ciara , Gibbons Catherine , Murphy Nuala , Kilbane Mark , van der Kamp Susan , McKenna Malachi

Background: This case illustrates the longitudinal improvements quantified by serial bone mineral density scans in an adolescent female with juvenile idiopathic osteoporosis treated with pamidronate.Presenting problem: The girl in question presented at 11 years and 10 months with a 5-month history of increasing back pain. A MRI scan prior to referral had indicated vertebral collapse and osteopenia. She had no medical, social or developmental history of n...

ba0003oc5.5 | Important pathways in bone biology and cancer | ECTS2014

Rs55710688 in the Kozak sequence of WNT16 increases translation efficiency and is associated with osteoporosis related parameters

Hendrickx Gretl , Boudin Eveline , Fijalkowski Igor , Nielsen Torben Leo , Andersen Marianne , Brixen Kim , Van Hul Wim

Recent studies confirmed the role of WNT16 in bone mineral density (BMD), bone strength and fracture risk. These findings made WNT16 interesting for further genetic and functional studies to clarify its effect on osteoporosis related parameters.A WNT16 candidate gene association study was performed in men from the Odense Androgen Study (OAS). Five tagSNPs and one multimarker test were selected for genotyping to cover most of th...

ba0003oc6.2 | Osteoporosis treatment and the effects of physical activity | ECTS2014

Gender-specific associations between physical functioning, bone quality, and fracture risk in older people

Furrer Regula , van Schoor Natasja , de Haan Arnold , Lips Paul , de Jongh Renate

Introduction: Measures of physical function may be related to osteoporosis and fractures in older individuals and may thus be used in the identification of individuals at high fracture risk.Aim: The aim of this study was to investigate which measures of physical functioning are associated with bone quality and fracture incidence and whether gender-specific differences exist within these associations.Methods: We studied 1486 partici...

ba0003pp135 | Cell biology: osteoblasts and bone formation | ECTS2014

High-resolution molecular validation of self-renewal and spontaneous differentiation in adipose-tissue derived human mesenchymal stem cells cultured in human platelet lysate

Dudakovic Amel , Camilleri Emily , Riester Scott , Westendorf Jennifer , Kakar Sanjeev , Dietz Allan , van Wijnen Andre

Improving the effectiveness of adipose-derived human mesenchymal stromal/stem cells (AMSCs) for skeletal therapies requires a detailed molecular characterization of mechanisms supporting cell proliferation and multi-potency of AMSCs. We compared gene expression data obtained by high-throughput RNA sequencing and RT-qPCR of actively proliferating and uninduced post-proliferative AMSCs with flow cytometry data for mesenchymal stem cell markers (e.g., CD44, CD73/NT5E, CD90/THY1 a...

ba0003pp265 | Osteoporosis: pathophysiology and epidemiology | ECTS2014

High prevalence of vertebral fractures at time of screening for orthotopic liver transplantation

Krol Charlotte , Dekkers Olaf , Kroon Herman , Rabelink Ton , van Hoek Bart , Hamdy Neveen

Purpose: Osteoporosis and fractures are prevalent in orthotopic liver transplant (OLT) recipients but data on these skeletal complications are scarce in patients with end-stage liver disease awaiting liver transplantation. The aim of our study was to evaluate the prevalence of osteoporosis and vertebral fractures at screening for OLT, to determine risk factors for skeletal pathology and to evaluate the predictive value of BMD for fracture risk in these patients.<p class="a...

ba0003pp271 | Osteoporosis: pathophysiology and epidemiology | ECTS2014

Secondary causes for osteoporosis significantly contribute to fracture risk in patients with osteopenia and a recent fracture

Malgo Frank , Appelman-Dijkstra Natasha , Termaat Frank , van der Heide Huub , Schipper Inger , Hamdy Neveen

Introduction: The reported prevalence of secondary causes for osteoporosis in men and women aged ≥50 years with a fracture is 35–60%, but data on these causes are scarce in patients with osteopenia and fractures.Objective: To investigate whether secondary causes for osteoporosis are prevalent and may contribute to fracture risk in patients aged ≥50 years with osteopenia and a recent fracture.Materials and methods: ...

ba0003pp382 | Other diseases of bone and mineral metabolism | ECTS2014

Osteogenic differentiation of fibroblast derived from patients with fybrodisplasia ossificans progressiva

Bravenboer Nathalie , Micha Dimitra , van Essen Huib , Netelenbos Coen , Eekhoff Marelise , Pals Gerard

Fibrodysplasia ossificans progressiva (FOP) is a rare, extremely disabling genetic disorder characterized by progressive heterotopic ossification preceded by episodic inflammatory soft tissue swellings (flare ups) leading to early death. There is no proven effective treatment yet. We aimed to develop an in vitro system to investigate the working mechanism of flare ups induced ossification.Skin biopsies were obtained from four patients with FOP. ...

ba0004oc17 | (1) | ICCBH2015

Inhibition of TGFβ signalling delays ossification in patients with fibrodysplasia ossificans progressiva

Micha Dimitra , Voermans Elise , Huib van Essen , Drukker Jesse , Netelenbos Coen , Eekhoff Marelise , Bravenboer Nathalie

Fibrodysplasia ossificans progressiva (FOP) is a rare congenital disorder characterized by progressive heterotopic ossification. FOP patients only present great toe malformations at birth. However, as they grow older they develop soft tissue lumps as a result of flare-ups causing the irreversible replacement of skeletal muscle tissue with bone tissue leading to cumulative physical immobility. Classical FOP patients possess a mutation (c.617G>A; R206H) in the activin recept...

ba0004p10 | (1) | ICCBH2015

Infantile Blount's disease: histopathologic changes in the proximal tibial metaphysis -- comparison between medial and lateral specimens

Hollman Freek , Vroemen Pascal , Rompa Paul , Moh Prosper , van Rhijn Lodewijk , Weltink Tim , Staal Heleen

Only minor literature on histopathologic changes in Blount’s disease is available. This study presents the histologic findings of biopsies harvested from the medial and lateral part of the proximal tibia during the W/M serrated osteotomy in patients with infantile Blount’s disease, performed in Ghana. In this study it is hypothesized that the medial metaphyseal area in these children will present a different histological morphology compared to the lateral metaphyseal...

ba0004p30 | (1) | ICCBH2015

Whole-body MR imaging as diagnostic tool in children with hereditary multiple osteochondromas

Staal Heleen , Dremmen Marjolein , Robben Simon , Witlox Adhiambo , van Rhijn Lodewijk

Patients with hereditary multiple osteochondromas (HMO) undergo frequent X-rays to evaluate the growth of the osteochondromas. The conventional radiographs show clear images of the growth of the bony part of the osteochondromas and of the growth direction of the long bones. However the cartilage cap on the osteochondroma nor the cartilage of the nearby epiphysis or the surrounding soft tissue of the osteochondromas is shown. Besides these disadvantages taking frequent radiogra...