Bone Abstracts

Introduction: The patients with rheumatoid arthritis (RA) are less physically active than the general population. The aim of the study is to assess the effect of two exercise programs on the functional status of patients with early RA.Methods: Fifteen patients with early RA underwent ten high-intensity dynamic exercises using Enraf-Nonius gym for 45–60 min, including aerobic part (En-Cardio) and 18–20 muscle-strengthening exercises (En-Dynamic ...

Osteogenesis Imperfecta (OI) is in most cases a congenital disease of collagen. The mutations have been reported in COLIA1 and COLIA2 genes, localised to chromosomes 17 and 7 respectively. The incidence at birth is 6–20/100 000. Children and youths with OI often display a complex and heterogeneous picture with fragile skeleton, fractures, curvature in the long bones, short stature, pain and limitations in mobility and everyday activity. The impact of those factors for the...

Objective: To investigate i) the analytic stability of PTH in venous blood specimens in serum tubes processed at different time intervals after collection compared to immediately processed blood samples collected in K2EDTA tubes, and ii) whether storage of samples in serum tubes for 5 years at −20 °C had an effect on stability of PTH.Methods: Venous blood samples were collected from ten healthy Caucasian females. One K2EDTA tube and three seru...

Introduction: Recent data suggest that imbalances in lipid metabolism affect bone cell function resulting in osteoporosis. Here, we investigated the role of apolipoprotein E (ApoE), essential component of chylomicron and very low density Lipoprotein metabolic pathways, in the regulation of osteoblast and osteoclast function and thus in the pathogenesis of osteoporosis.Material and methods: We used apoE deficient (ApoE−/−) and wild ...

Introduction: Evidence in literature shows how is useful to use antiresorptive drugs such as bisphosphonates, in severe osteoporosi severe after PTH (1–34 or 1–84) treatment.Methods: This study was divided into two parts: the first one analyzed BMD changes by DXA at the lumbar and femoral and serum osteocalcin and β-CTX, monitoring their performance after 6, 12 and 18 months in 71 women with severe postmenopausal osteoporosis, treated for ...

Recent meta-analyses of vitamin D without co-administration of calcium have not demonstrated fracture prevention, possibly through lack of power, inappropriate choice of doses, or failure to target the intervention to deficient populations. Bone mineral density (BMD) is able to detect biologically significant effects in much smaller cohorts, so is a relevant surrogate measure with which to re-assess the skeletal efficacy of these supplements. We searched Web of Science, Embase...

Introduction: Bisphosphonates gain increasingly greater significance in treatment oncologic diseases with bone metastasis. However, a lot of articles have lately been published in dental and oncological journals on jaw osteonecrosis (ONJ) associated with long-term ingestion of bisphosphonates. Besides extension of clinical recommendations for zolendronate use, most commonly referred to in connection with ONJ, for treatment of Paget’s diseaseand other disturbances of bone ...

Objectives: Erythropoietic protoporphyria (EPP) is a rare disease with cutaneous photosensitivity, in which patients avoid sun exposure and use sunscreen. Our purpose was to study bone mineral density (BMD), serum 25-OHD levels and other mineral parameters, to evaluate the impact of these measures in the follow-up of EPP patients.Patients and methods: A ten EPP patients (median age 25; range 22–55, four males and six females), were study for clinica...

Objectives: To describe the clinical, laboratory, radiological and genetic findings of camptodactyly-arthropathycoxa vara-pericarditis (CACP) syndrome in Saudi children.Methods: Medical records of all children with CACP syndrome seen between June 1990 and June 2012 at KFSHRC-Riyadh were reviewed. The data included: gender, age at disease onset, referral diagnosis, clinical and radiological features and molecular genetic studies as well as functional stat...

Aim: To investigate the effect of psychoeducation program in families with osteogenesis imperfecta (OI).Methods: Sixteen family members of OI patients were included in the program. The research was designed as a semi structural, semi experimental pre and post test. The scales used were; Introductory Information Form, Burden Interview (BI), Coping Strategies Scale (CSS), Problem Solving Inventory (PSI), and Psychosocial Adjustment to Illness Scale (PAIS)....