Bone Abstracts

Calcium (Ca) and vitamin D nutritional status effects on oral health were evaluated in 85 healthy women aged between 20 and 30 years (24.6±0.4). They attended the first year of the Nutrition Carrier at the Private University (ISALUD, Buenos Aires, Argentine). Usual Ca intake (CaI) was determined by a food-frequency questionnaire that included consumption of dairy products and calcium-enriched foods. Blood samples were obtained in a fasting state in winter: the end of Augu...

Background: Hypophosphatasia (HPP) results from inactivating mutation(s) in the gene for tissue non-specific alkaline phosphatase (TNSALP). Substantial improvement has been reported in skeletal mineralization and physical function in patients (pts) with life-threatening perinatal and infantile HPP treated for 48 weaks with asfotase alfa, a bone-targeted recombinant human TNSALP.Objective: To evaluate long-term efficacy and tolerability of asfotase alfa i...

Objectives: Anorexia nervosa (AN) is a life-threatening eating disorder often associated with reduced bone mass. The aim of the present study was to investigate vitamin D status and the association with BMI, fat mass and bone mineral density (BMD) during a novel intensive nutrition therapy in young AN women.Methods: Twenty-five female AN patients (20.1±2.3 years, BMI 15.5±0.9 kg/m2) admitted to a specialised inpatient eating disorder...

Introduction: Vertebral fracture has been recognized as a major health concern. Our purposes were to evaluate the trends in the incidence and mortality of vertebral fracture between 2008 and 2012 and predict the number of vertebral fracture that will occur in Korea up to 2025, using nationwide data from the National Health Insurance Service (NHIS).Method: A nationwide data set was evaluated to identify all new visits to medical institutes for vertebral f...

Introduction: Bioelectrical impendance analysis (BIA) and dual enargy X-ray absorptiometry (DXA) are two most common methods used for body composition analysis. The aim of this study was to investigate: i) if there is a correlation between body mineral content (BMC) determined by BIA and by DXA for bone mineral content (BMC) and ii) correlation of BMC (BIA) vs bone mineral density (BMD) of L1–L4 spine, dual femur total mean and neck mean.Methods: Tw...

Objectives: To establish the average bone mineral density (BMD) and bone mineral content (BMC) in young male population from the different ethno-geographical groupsMaterials and methods: Estimations of the calcaneal BMD (g/cm2) and BMC (r), using on ALOKA-5.0 DXA machine among Indian (n=58) and Nigerian (n=72) male students (17–20 years), were done. The anthropometric program included body weight, height, shoulder and th...

Introduction: Standard clinical treatments for postmenopausal osteoporosis utilize resorption-inhibiting drugs such as bisphosphonates, which selectively bind to bone mineral but also suppress bone formation over time. Prostaglandin E2 (PGE2) has bone-anabolic effects in vivo, but its clinical utility is hindered by side effects upon systemic administration. Since PGE2 acts on bone via the EP4 receptor, our approach utilizes a specific...

Periodontitis is an inflammatory disease that affects connective tissue attachments and the supporting bone that surrounds the teeth. Periodontal ligament fibroblasts induce the overexpression of matrix metalloproteinase (MMP), which is involved in inflammatory progression in periodontitis. Osteoclasts are responsible for skeletal modeling and remodeling but may also destroy bone in several bone diseases, including osteoporosis and periodontitis. This study examined the anti-d...

The purposes of this present study were to compare the osteoconductivity and absorbability in patients of open wedge high tibial osteotomy with medially gaps filled with hydroxyapatite (HA) or beta-tricalcium phosphate (β-TCP).Total 41 knees of 40 patients in whose follow up period more than 1 year were enrolled. The patients were divides into two groups, group I (22 knees, 21 patients) used HA and group II (19knees, 19 patients) used β-TCP...

Background: Pamidronate is FDA approved only in adults. It is frequently used off-label in the treatment of pediatric bone diseases, such as osteogenesis imperfecta, juvenile osteoporosis, and osteopenia in nonambulatory patients with cerebral palsy. The use of pamidronate in these conditions is relatively common, but there may be more to be understood about its role in other rare pediatric bone diseases.Presenting problem: Jansen’s Metaphyseal Chon...