Bone Abstracts

Objectives: Anorexia nervosa (AN) is a life-threatening eating disorder often associated with reduced bone mass. The aim of the present study was to investigate vitamin D status and the association with BMI, fat mass and bone mineral density (BMD) during a novel intensive nutrition therapy in young AN women.Methods: Twenty-five female AN patients (20.1±2.3 years, BMI 15.5±0.9 kg/m2) admitted to a specialised inpatient eating disorder...

Introduction: Vertebral fracture has been recognized as a major health concern. Our purposes were to evaluate the trends in the incidence and mortality of vertebral fracture between 2008 and 2012 and predict the number of vertebral fracture that will occur in Korea up to 2025, using nationwide data from the National Health Insurance Service (NHIS).Method: A nationwide data set was evaluated to identify all new visits to medical institutes for vertebral f...

Introduction: Bioelectrical impendance analysis (BIA) and dual enargy X-ray absorptiometry (DXA) are two most common methods used for body composition analysis. The aim of this study was to investigate: i) if there is a correlation between body mineral content (BMC) determined by BIA and by DXA for bone mineral content (BMC) and ii) correlation of BMC (BIA) vs bone mineral density (BMD) of L1–L4 spine, dual femur total mean and neck mean.Methods: Tw...

Objectives: To establish the average bone mineral density (BMD) and bone mineral content (BMC) in young male population from the different ethno-geographical groupsMaterials and methods: Estimations of the calcaneal BMD (g/cm2) and BMC (r), using on ALOKA-5.0 DXA machine among Indian (n=58) and Nigerian (n=72) male students (17–20 years), were done. The anthropometric program included body weight, height, shoulder and th...

Introduction: Standard clinical treatments for postmenopausal osteoporosis utilize resorption-inhibiting drugs such as bisphosphonates, which selectively bind to bone mineral but also suppress bone formation over time. Prostaglandin E2 (PGE2) has bone-anabolic effects in vivo, but its clinical utility is hindered by side effects upon systemic administration. Since PGE2 acts on bone via the EP4 receptor, our approach utilizes a specific...

Periodontitis is an inflammatory disease that affects connective tissue attachments and the supporting bone that surrounds the teeth. Periodontal ligament fibroblasts induce the overexpression of matrix metalloproteinase (MMP), which is involved in inflammatory progression in periodontitis. Osteoclasts are responsible for skeletal modeling and remodeling but may also destroy bone in several bone diseases, including osteoporosis and periodontitis. This study examined the anti-d...

Background: Pamidronate is FDA approved only in adults. It is frequently used off-label in the treatment of pediatric bone diseases, such as osteogenesis imperfecta, juvenile osteoporosis, and osteopenia in nonambulatory patients with cerebral palsy. The use of pamidronate in these conditions is relatively common, but there may be more to be understood about its role in other rare pediatric bone diseases.Presenting problem: Jansen’s Metaphyseal Chon...

Introduction: Acute vertebral compression fractures cause severe back pain and need long time to heal. The progression of fracture or nonunion is not rare. The teriparatide is a synthetic parathyroid hormone which has been used as anabolic agent and treatment of osteoporosis. It can also be used for promoting fracture healing in special condition. Periodic infusion of teriparatide enhances bone formation and increases bone strength. We evaluated the effect of periodic teripara...

Introduction: To compare serum vitamin D levels in elderly patients with or without osteoporotic spinal compression fractures (OSCF) and to evaluate a correlation between serum vitamin D level and several variables such as age, and bone mineral density (BMD), bone turnover markers.Methods: The medical records of 78 patients with OSCF (fracture group) and 84 age-matched control patients who were diagnosed osteoporosis without OSCF (control group) were rev...

Introduction: To analyze clinical assessment and efficacy of once-yearly i.v. zoledronic acid for osteoporosis.Materials and methods: The subjects were 322 osteoporotic patients who received more than single infusion of zoledronic acid in our hospital from October 2008 to March 2011. On clinical assessment, the adherence was evaluated by measuring the rate of reinfusion. Adverse events were recorded for safety assessment. For efficacy assessment, the bon...