Bone Abstracts

Backgrounds: Bladder cancer is the most common malignancy and also highest mortality of the urinary tract cancer. Urothelial cell carcinoma (UCC) is the most histopathological subtype of bladder cancer. Epidemiological studies have indicated that bladder cancer risk for cigarette smoking is more than twice than never smoking and that current cigarette smoking triples bladder cancer risk relative to never smoking. Cigarette smoking after bladder cancer diagnosis decreases cance...

Background: There have been many studies on the association between vitamin D and testosterone in the world. But it has not been fully clarified. Furthermore, data in Korean men is limited. This study aimed to determine the association between vitamin D and testosterone levels in korean men.Methods: This cross sectional study analyzed serum 25-hydroxyvitamin D (25(OH)D) and total testosterone in 365 Korean men over 25 years of age who visited a local uni...

Introduction: Osteoporosis is a major bone disease among postmenopausal women. Measurement of BMD in the spine and hip is used as gold standard for the diagnosis of osteoporosis. ISCD recommended that posteroanterior L1-4 as the spine region of interest for BMD measurement. However, both L1-4 and L2-4 are used in the clinical and epidemiological studies. The aim of our study was to evaluate whether the differences of BMD between L1-4 and L2-4 would exist.<p class="abstext"...

Smurf1 is an E3 ubiquitin ligase for Smad1/5, Runx2 and MEKK2 and plays a role as a negative regulator for osteoblast differentiation and bone formation. However, the role of Smurf1 in odontoblast differentiation has not been elucidated. Previously, we reported that histone deacetylase inhibitors (HDACi) enhance odontoblast differentiation through the upregulation of Nfic expression. In this study, we investigated the regulatory effect of HDACi on Smurf1 expression and the rol...

Inflammatory processes play a role in osteoclastogenesis. C-reactive protein (CRP), an acute phase reactant that reflects different degree of inflammation. More recently, accumulating evidence suggest that CRP is not only an inflammatory marker but also direct cause of diseases. Therefore, we examined the direct effects of CRP on osteoclast formation using RAW 264.7 cells. CRP significantly inhibited RANKL-induced TRAP-positive multinucleated cell formation in RAW 264.7 cell c...

A 20-year-old male presented following a fall down. He was diagnosed with a C5–C7 burst fracture and underwent a cervical fixation surgery. He was transferred to inpatient rehabilitation with C6 ASIA A tetraplegia.70 days after the operation, he began to have intermittent mild fever with a temperature of 37.4 oC. On postoperative day 72, left thigh was noted to be edematous. The circumferential difference between the lower extremities mea...

Background and objectives: Fracture in rheumatoid arthritis (RA) patient is more frequent than general population. One of the important reasons is use of glucocorticoid (GC) for treatment of RA. In this study, we aimed to identify the effect of GC on fracture of different site.Methods: Among RA patients &gE;19 years, we established a retrospective cohort using Korean national healthcare claims database from Jan 2010 to Dec 2010, and then followed up unti...

Better quality of cartilage repair in developing skeleton is recognized. The associated repair factors may be important in osteoarthritis and those factors would be the targets for the management of osteoarthritis. Microarray analysis of cartilage repair in rat knee joint was therefore carried out. Surgical injury on the femoral cartilage of the right patello-femoral joint in the 3- and 8-week-old rats for 2 weeks was first made. The left side of joint cartilage was used as th...

Gene deletion or treatments with a cathepsin K (CatK) inhibitor in mature preclinical models result not only result in lower bone resorption but also in higher bone formation (BF) on both remodeling and modeling surfaces. Although increased production of clastokines and matrix-derived growth factors may explain the increased BF at remodeling surfaces, the mechanisms for greater BF at modeling surfaces, including the periosteum, remain unexplained. We hypothesized that the abse...

In bone marrow, bone marrow stromal cells (BMSCs) have the capacity to differentiate into osteoblasts and adipocytes. Onset of osteoporosis with age stems in part from the enhanced bone marrow adipogenesis that represses osteogenesis. In this study, we demonstrate that disruption of nuclear factor I-C (NFI-C) impairs osteoblast differentiation and bone formation, and increases bone marrow adipocytes. Interestingly, NFI-C controls postnatal bone formation but does not influence...