Bone Abstracts

Aim: Alendronate enhances bone morphogenetic proteins (BMP)-mediated osteoblast differentiation. A balanced regulation of inhibitors of DNA binding/differentiation (Ids) plays an important role in BMP-induced osteoblast differentiation. However, there are no studies on the possible roles of Id genes in alendronate-induced osteoblast differentiation. This study investigated the effect of alendronate on the expression of Id genes in osteoblast differentiation. ...

Introduction: It has been reported that low bone mass is common in patients with pulmonary disorders such as chronic obstructive pulmonary disease. However, in healthy non-smoking women, the relationship between bone mass and pulmonary function has yet to be clarified. The object of this study was to determine whether pulmonary function is related to BMD in healthy non-smoking women based on menopausal status.Methods: This study was a cross-sectional stu...

When cells detach from or re-attach to the substrates, there is a drastic change in shape. Molecular mechanism by which controls shape upon cell attachment to the substrates was studied in osteoblastic MC3T3-E1 cells in vitro. Most striking feature found in the ovoid cells detached from the substrates was densely packed cortical actin bundles (CAB) encircling cells. Cells lost the CAB upon attachment and spreading on to the substrates. CABs were under control of small...

Notch signaling plays a central role in various cell fate decisions, including skeletal development. Recently, Notch signaling was implicated in osteoclast differentiation and maturation, including the resorption activity of osteoclasts. However, the specific involvement of notch signaling in resorption activity was not fully investigated. Here, we investigated the roles of Notch signaling in the resorption activity of osteoclasts by use of the γ-secretase inhibitor diben...

Objectives: To evaluate risk factors of subsequent vertebral fracture following acute osteoporotic vertebral compression fracture.Methods: As a multicenter retrospective study, we recruited 135 patients treated for acute osteoporotic compression fracture with available spine image taken at 1-year follow-up in three hospitals. The patients were divided into two groups according to occurrence of subsequent vertebral fracture. Two groups were analyzed with ...

Engulfment adaptor phosphotyrosine-binding (PTB) domain containing 1 (GULP1) is an adaptor protein involved in the engulfment of apoptotic cells via phagocytosis. Although GULP1 is widely expressed in various tissues, including the brain, muscle, testis, and bone, the function of GULP1 has not been well studied. Here, we investigated whether GULP1 plays a role in the regulation of bone remodeling and examined its expression in bone cells. Conditional Gulp1 floxed mice...

The present study figured out the relationship between social network and osteoporosis among elderly women. Social network could be beneficial to one’s health since it works as social capital providing several supports. On the other hand, social network can also be a source of social burden aggravating one’s health. To examine the seemingly contradicting associations, Korean Urban Rural Elderly Study (KURE) data was analyzed. There were 1938 older women aged over 65,...

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Introduction: Osteoporotic fractures are known to be costly to society but estimates tend to be based on small scale prospective studies. In the following we report national data for healthcare costs due to fractures in patients with osteoporosis.Study population and methods: All Danish residents aged 35+, mean age 70.5 years, 13% men, 27.3% prior major osteoporotic fracture, who began bisphosphonates for osteoporosis between 1/1997 and 12/2002 (n</e...

Purpose: The aim of this study is to determine the chemical information in trabecular bone by Raman spectroscopy in the human distal femur at the microstructural level.Methods: The subchondral trabeculae were obtained from the middle of medial articular surface of the distal femurs in the two cadavers (one is with and the other is without OA). Raman spectroscopy, a non-destructive technique, was employed to determine the chemical information of the trabe...