Bone Abstracts

Sustained release of bone morphogeneic protein (BMP)-2 by heparin-contained biomaterials is advantageous for bone tissue regeneration using low dose BMP-2. However, its effect in high dose BMP-2 is still unclear and should be clarified considering the clinical use of high dose of BMP-2 in spine and oral surgery. This study aimed to evaluate the efficacy of heparin-conjugated collagen sponge (HCS) in high dose BMP-2 delivery by investigating in vivo initial osteogenic regulatio...

Study Design: Retrospective study.Purpose: To estimate the usefulness of bone scan and magnetic resonance imaging (MRI) for the diagnosis of new fracture in osteoporotic vertebral fractures.Overview of Literature: The diagnosis of new fracture in osteoporotic vertebral fractures requires simple X-ray and supplementary studies.Methods: We analyzed 87 vertebrae in 44 patients, who diagnosed with osteoporotic ve...

Introduction: The purpose of this prospective study is to investigate whether bisphosphonate-based anti-osteoporosis medication affects fracture healing and clinical outcomes of conservatively treated osteoporotic spinal fractures (OSFs).Method: A total of 105 patients who were diagnosed with acute OSFs were prospectively enrolled. According to their previous medication history, the patients were allocated into group I (n=39, no history of bisph...

Osteoclasts are cells specialized for resorption of calcified tissue. Osteoclasts are formed from precursor cells of monocyte lineage under the control of receptor activator of nuclear factor kappaB ligand (RANKL). Mitogen- and stress-activated protein kinase 1 (MSK1) has been reported to be an important regulator of immune response and mitogenic signaling. In this study, we for the first time found that MSK1 was activated by RANKL in osteoclast precursor, bone marrow macropha...

Objective: The purpose of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in leptin (LEP), its receptor (LEPR) and β adrenergic receptor (ADRB) genes and bone mineral density (BMD) in postmenopausal Korean women.Methods: The LEP c.280G>A, LEPR c.326A>G, c.668A>G, c.1968G>C, c.2096C>T, ADRB2 c.46A>G, c.79C>G, c.718T>C, c....

Introduction: Advancing age is associated with decline in bone and muscle mass and quality. Sarcopenia, one of Geriatric syndromes, is defined as the age-associated loss of skeletal muscle mass and function resulting in disability, poor QOL and death.Objective: To evaluate the prevalence of sarcopenia and its association with osteopenia/osteoporosis in Korean PMW.Materials and methods: Subjects: total 225 Korean PMW over 50 years w...

Aim: Alendronate enhances bone morphogenetic proteins (BMP)-mediated osteoblast differentiation. A balanced regulation of inhibitors of DNA binding/differentiation (Ids) plays an important role in BMP-induced osteoblast differentiation. However, there are no studies on the possible roles of Id genes in alendronate-induced osteoblast differentiation. This study investigated the effect of alendronate on the expression of Id genes in osteoblast differentiation. ...

Introduction: It has been reported that low bone mass is common in patients with pulmonary disorders such as chronic obstructive pulmonary disease. However, in healthy non-smoking women, the relationship between bone mass and pulmonary function has yet to be clarified. The object of this study was to determine whether pulmonary function is related to BMD in healthy non-smoking women based on menopausal status.Methods: This study was a cross-sectional stu...

When cells detach from or re-attach to the substrates, there is a drastic change in shape. Molecular mechanism by which controls shape upon cell attachment to the substrates was studied in osteoblastic MC3T3-E1 cells in vitro. Most striking feature found in the ovoid cells detached from the substrates was densely packed cortical actin bundles (CAB) encircling cells. Cells lost the CAB upon attachment and spreading on to the substrates. CABs were under control of small...

Notch signaling plays a central role in various cell fate decisions, including skeletal development. Recently, Notch signaling was implicated in osteoclast differentiation and maturation, including the resorption activity of osteoclasts. However, the specific involvement of notch signaling in resorption activity was not fully investigated. Here, we investigated the roles of Notch signaling in the resorption activity of osteoclasts by use of the γ-secretase inhibitor diben...