Bone Abstracts

Purpose: The aim of this study is to determine the chemical information in trabecular bone by Raman spectroscopy in the human distal femur at the microstructural level.Methods: The subchondral trabeculae were obtained from the middle of medial articular surface of the distal femurs in the two cadavers (one is with and the other is without OA). Raman spectroscopy, a non-destructive technique, was employed to determine the chemical information of the trabe...

Recent genetic studies in rodents have revealed that circulating serotonin plays a key role in regulating bone formation and skeletal mass. However, the reported effects of circulating serotonin on bone mass in humans have been conflicting. We determined whether circulating serotonin levels influenced the rate of bone loss and fractures in males.We assessed the effect of serum serotonin on bone loss rate in a population-based cohort of 202 ambulatory mal...

Inhibition of an increase of osteoclasts has become the most important treatment for osteoporosis. The CXCR4 antagonist, AMD3100, plays an important role in the mobilization of osteoclast precursors within bone marrow (BM). However, the actual therapeutic impact of AMD3100 in osteoporosis has not yet been ascertained. Here we demonstrate the therapeutic effect of AMD3100 in the treatment of ovariectomy-induced osteoporosis in mice. We found that treatment with AMD3100 resulted...

Tyrosine kinase c-Src plays an important role in actin ring formation and bone resorption activity in osteoclasts. Therefore, c-Src has been targeted for the treatment of osteolytic disorders. In the present study, we investigated anti-resorptive effect of dibenzazepine (DBZ), one of the γ-secretase inhibitors (GSIs), on osteoclast-mediated excessive bone resorption. DBZ did not affect osteoclast differentiation, but disturbed actin ring formation and inhibited osteoclast...

Background and objectives: The association between excess calcium intake and cardiovascular mortality has been reported, but the association has not yet been explored according to serum vitamin D status. Thus, we investigated the relation of dietary calcium intake and Framingham risk score (FRS) according to serum 25-hydroxyvitamin D (25(OH)D) status.Methods: A total of 7809 subjects (3452 males and 4357 female) aged over 40 years from the data of the Ko...

Background and objectives: Vitamin D deficiency causes calcium-depleted bone, which further weakens the bones and increases the risk of fractures. Also, It is known as related to obstetrics problem like gestational diabetes, infections, preeclampsia and incidence of caesarean section as well as glucose metabolism, immune system, cardiovascular diseases and cancer.Recently, the relationship between preterm birth and vitamin D deficiency becomes the main i...

Osteoclasts are bone-resorbing multinucleated cells that differentiate from monocyte/macrophage-lineage precursors. Bone destruction and osteoporosis are attributed to excessively activated osteoclasts. Osteoclast differentiation is governed by diverse regulatory processes including nuclear factor-activated T cells c1 (NFATc1) activation in response to RANKL. The mechanism of epigenetic regulation of NFATc1 in osteoclastogenesis not investigated yet. Here we test a hypothesis ...

The purpose of this study is to understand the changes of TBS scores in Asian females by comparing 1990’s and 2010’s DXA images.We have compared the DXA images of 3774 Korean females (age: 20–79) to Japanese (age: 20–79). While Korean DXA images were obtained in 2014 and 2015, Japanese data were obtained in 1996. Participants who have abnormal DXA images or lumbar disease were excluded. TBSiNsight® software (v. 2.1.1, ...

The purpose of this study is to assess the correlation of trabecular bone score (TBS) to variable factors, i.e. sex, age, body size and BMD. Moreover, we want to find variables of correlation coefficient change with aging.We randomly selected 2,906 subjects (1726 female and 1180 male, age range 20’s to 70’s) from several hospitals in Korea. Participants who have abnormal Dual Energy X-ray Absorptiometry (DXA) images or lumbar disease were exclu...

Mesenchymal cells alter and retain their phenotype during skeletal development through activation or suppression of signaling pathways. For example, we have shown that Wnt3a only stimulates osteoblast differentiation in cells with intrinsic osteogenic potential (e.g., MC3T3-E1 pre-osteoblasts) and not in fat cell precursors or fibroblasts (respectively, 3T3-L1 pre-adipocytes or NIH3T3 fibroblasts). Wnt3a promotes osteogenesis in part by stimulating autocrine production of the ...