Bone Abstracts

Adiposity, physical inactivity and sedentary behavior have become an increasing problem during the past decade and raise concerns about future health. Increased sedentary behavior may change the body composition by increasing the fat mass (FM) relative to the lean mass (LM). These changes may influence bone health. This study aimed at evaluating the influence of BMI and body fat percent (BF%) and LM on children’s bone health represented by bone mineral content (BMC), bone...

Lack of extension of the knee and fixed flexion of the knee may occur in patients with arthrogryposis, rheumatoid arthritis, achondroplasia, osteogenesis imperfecta, cerebral palsy and other conditions. They develop a crouch gait and this is an energy non-efficient condition that causes a compensatory flexion deformity of the hip and lumbar lordosis. Recommended treatments have included bracing, physical therapy, posterior release, distal femoral osteotomy or progressive distr...

Epigenetic mechanisms regulate gene expression and are heritable through cell divisions even though they do not involve modifications in the gene sequence. They include methylation and other chemical modifications of cytosine nucleotides, histone posttranslational modifications, microRNAs and other non-coding RNAs. Most cytosines in the human genome are methylated, particularly in the inactive, tightly packed, heterochromatin of autosomes, and the inactivated X-chromosome in f...

Blood vessels and bone display spatial and functional relationships. While the coupling of angiogenesis to bone formation during modeling situations is well documented, the vessels roles in bone remodeling, although widely acknowledged, remain poorly explored. In order to image and quantify the bone vessel network in rodents, we contrasted the vascular bed with barium sulfate, followed by histology or either conventional or synchrotron radiation micro-computed tomography. We s...

Recent studies confirmed the role of WNT16 in bone mineral density (BMD), bone strength and fracture risk. These findings made WNT16 interesting for further genetic and functional studies to clarify its effect on osteoporosis related parameters.A WNT16 candidate gene association study was performed in men from the Odense Androgen Study (OAS). Five tagSNPs and one multimarker test were selected for genotyping to cover most of th...

Osteoporosis is a multifactorial disease that represents an increase public health problem, given the impact on functional independence and quality of life. Among the favoring factors to the imbalance in bone cell activity, the hypoestrogenism is primordial. Strength training (ST) proves to be effective because of its ability to stimulate estrogen receptor independent of ligand. In this study, we analyzed the action of ST on bone quality of rats during the aging. For this stud...

Introduction: Osteoarthritis is the most common and debilitating degenerative arthropathy. Prevention and patient education are part of the international recommendations. A survey was realized with 43 medical specialists at the Hospital University of Casablanca, about their point of views on the role of therapeutic education for patients with osteoarthritis of the lower limb. Doctors justified the importance of patient education.Study purpose: Evaluate o...

Molecules secreted by the osteoclast or ‘clastokynes’ are essential to stimulate bone formation by osteoblasts. Treatments with bisphosphates and Denosumab target osteoclast survival and differentiation. This suppresses bone turnover and is suspected to increase the risk of atypical fractures in the long term. A solution to overcome this is to develop strategies that target selectively the activity of osteoclasts without affecting their survival or differentiation. S...

A Danish database initiative was established in 2003 with the purpose of evaluating patients treated with teriparatide. After the introduction in 2006 of 1–84-PTH, these patients were also included. A total of 1494 patients from 19 centers were reported to the database, until closure in 2011. The reported patients correspond to a third of all patients in Denmark receiving anabolic treatment during this time period. With regard to age and sex the reported patients do not d...

Introduction and aim: Many patients with osteoporosis are elderly and oral health is an important aspect of patient care especially in patients on bisphosphonates. Our aim was to determine oral health attitudes and practices in patients with osteoporosis receiving bisphosphonates.Methods: A questionnaire study was conducted after informed consent on cognitively intact patients diagnosed with osteoporosis who were attending hospital Osteoporosis clinic an...