Bone Abstracts

Objectives: We recently demonstrated that cow’s milk allergic infants who received an amino acid-based formula (AAF) for 16 weeks as oral feeding had adequate mineral status (1). One factor that may negatively affect mineral solubility and bioavailability and hence mineral status, is high gastric pH (2), but data on this in infants are lacking. Therefore, the present study evaluates serum concentrations of phosphorus, calcium and magnesium in a subgroup of infants on AAF ...

Background: We identified a family with early onset X-linked osteoporosis and fracturesMethods: We performed whole exome sequencing of the X chromosome in three affected members. After discovering a putative pathogenic variant we performed Sanger sequencing of all exons of this gene in other members of this family and in 95 unrelated men suspected of OI type I without COL1A1/2 mutations. We also genotyped a SNP in this gene (minor allele frequency 0.02) ...

Background and aims: Bone and joint infections like osteomyelitis and septic arthritis occur in ~3–12/100.000 children per year in high-income countries with predominance in males. The most common causative pathogen is Staphylococcus aureus, however, only in 50% pathogen detection succeeds. The aim of this study is to describe clinical characteristics of osteomyelitis and septic arthritis in children recruited within the EUCLIDS network (<a href="http://www.eucli...

A number of cancers develop in the skeleton or will metastasize to bone, including multiple myeloma and solid tumours such as breast and prostate cancer. Once established in the skeleton, cancer cells have the ability to modify the environment and cause devastating bone disease. The last decade has seen considerable progress in defining the critical cellular and molecular mechanisms responsible and also identified new roles for the cells of bone in the pathogenesis of metastas...

Abstract unavailable....

Our skeleton needs to carry the body weight and to resist mechanical impacts. This capability or, conversely, bone fragility are controlled by the amount of bone mass, the shape and internal architecture of the bones, as well as by the material of which they are built. Bone material consists of a complex multi-scale arrangement of mineralized collagen fibrils containing also water, proteoglycans as well as some non-collagenous proteins. This organization is by no means constan...

Biographical DetailsPeter Fratzl is director at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, and honorary professor at Humboldt University Berlin and Potsdam University. He holds an engineering degree from Ecole Polytechnique in Paris, France, and a doctorate in Physics from the University of Vienna, Austria. His scientific interests include the relation betwee...

There is discussed an interrelation of BMD, progressing of erosive and destructive changes in hands and feet with development of vertebral deformations in rheumatoid arthritis (RA).The aim: To receive data on bone mineral density (BMD), erosive and destructive changes in hands and feet and vertebral deformations in patients with RA.Materials/methods: In this research, it was included 106 women, with RA, age 23–69 years. In all...

Abstract not submitted...

Multiphoton microscopy (MPM) is a powerful approach to visualize live cells and tissues, including bone, in three dimensions and over time. To enable preclinical longitudinal monitoring of bone by intravital MPM we developed an animal window model of bone using existing tissue engineering strategies. Electrospun polycaprolactone scaffolds and human mesenchymal stem cells after osteoblastic differentiation, in vitro, were implanted into the mouse skin in the presence o...