Bone Abstracts

Objectives: Young male jockeys undertake calorie restriction and high volumes of physical activity during periods of musculoskeletal growth and development. Previous research shows that jockeys have compromised bone health1–4 and display disordered eating5–7. Restricted intakes of calcium and vitamin D, together with excessive amounts of exercise, increase the risk of osteoporosis in males8. The aim of this study was to establish whet...

Purpose: The purpose of this study was to scan femoral heads from cadaveric donors and investigate the microarchitecture within each femoral head comprehensively.Material and methods: Ten proximal femora was harvested from eight human cadaveric donors and these specimens were scanned using micro-computed tomography. Reconstructed batches of images were aligned along the main trabecular direction (MTD). The upper hemisphere of each femoral head was includ...

Objectives: Hypophosphatasia (HPP) is a rare metabolic disease caused by loss-of-function mutation(s) in the gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). HPP in infants is characterized by poor skeletal mineralization, respiratory compromise, and a high risk of mortality. We previously reported improved mineralization and respiratory function in 15 patients enrolled in this second study of asfotase alfa, a bone-targeted recombinant human TNSALP, in infants a...

Objective: Childhood onset Crohn’s disease (CO-CD) is associated with musculoskeletal deficits. However, there are limited data regarding muscle-bone outcomes in adults with CO-CD. The current study aimed to comprehensively assess the muscle-fat-bone unit in young adults with CO-CD, using novel methods of MRI, in comparison with healthy controls.Methods: Trabecular microarchitecture and cortical geometry of the distal femur were assessed using 3T mi...

Introduction: Intracellular fat within muscle and visceral tissue has been suggested to adversely influence bone development.Design: We aimed to compare associations between intramuscular and subcutaneous fat and cortical bone outcomes in young adults, in cross-sectional analyses based on the Avon Longitudinal Study of Parents and Children.Method: Data were collected from a research clinic conducted at 17 years of age. Intramuscula...

Women suffer more fragility fractures in old age and have a higher incidence of fractures at the femoral neck region compared to men who have higher incidence of trochanteric femoral fractures. The purpose of this cross-sectional study was to analyze associations between physical activity (PA) and bone mass distribution at the femoral neck (FN) and trochanter (TR) in young adults. A left hip DXA scan was used to measure bone mineral density (BMD) at the integral, superolateral...

Objectives: The aim of this study was to determine the relationship between 25-hydroxyvitamin D (25(OH) D) level and blood pressure (BP) in Saudi women and to assess the effect of BMI, as a measure of adiposity, on this relationship.Methods: Three-hundred and three apparently healthy Saudi women (20–40 years old) were randomly selected for this cross-sectional study. All women signed an informed consent and the study was approved by the Ethical Comm...

Objective: To evaluate the bone mineral density (BMD) of the axial and appendicular skeleton in a group of collegiate dance students undergoing intensive training between a 24 months interval and to correlate these changes to the presence or absence of apparent athlete triad syndrome (ATS).Methods: Forty full time collegiate dance students were recruited from a tertiary Performing Arts Institute. All subjects had basic anthropometric measurements, a full...

Calcium (Ca) and vitamin D nutritional status effects on oral health were evaluated in 85 healthy women aged between 20 and 30 years (24.6±0.4). They attended the first year of the Nutrition Carrier at the Private University (ISALUD, Buenos Aires, Argentine). Usual Ca intake (CaI) was determined by a food-frequency questionnaire that included consumption of dairy products and calcium-enriched foods. Blood samples were obtained in a fasting state in winter: the end of Augu...

Background: Hypophosphatasia (HPP) results from inactivating mutation(s) in the gene for tissue non-specific alkaline phosphatase (TNSALP). Substantial improvement has been reported in skeletal mineralization and physical function in patients (pts) with life-threatening perinatal and infantile HPP treated for 48 weaks with asfotase alfa, a bone-targeted recombinant human TNSALP.Objective: To evaluate long-term efficacy and tolerability of asfotase alfa i...