Bone Abstracts

Introduction: Estrogen therapy decreases circulating levels of sclerostin, a protein product of SOST which increase in postmenopausal women. However, the mechanisms of estrogen on the expression of SOST remain unclear. This study was hypothesized that estrogen modulates SOST expression by interfering bone morphogenic protein (BMP) signaling on the basis that BMP is an inducer of SOST in osteoblasts.Description of methods: We investigated the expression o...

Objectives: The purpose of our study was to investigate RANK/RANKL/OPG system and the concentrations of other markers of bone turn-over in normal pregnancy and pre-eclampsia.Materials and methods: Forty five patients with pre-eclampsia, 78 healthy pregnant women and twenty non-pregnant women were included in the study. Sera concentrations of the markers of bone turn-over: osteoprotegrin (OPG), sRANKL, osteocalcin and CrosLaps – degradation products ...

Over the years, it has been demonstrated that the ability to maintain body core temperature in older adult’s declines with age. Temperature is a vital physical factor for cell growth and a downshift in core body temperature (<37 °C) might have a direct affect on maintaining bone density or repair fractures. Disruption in any of the cellular processes involved in bone remodelling leads to a net loss of bone mineral density and bone loss. Therefore our study looked...

Objective: Turner syndrome (TS) is a chromosomal aberration characterized by total or partial loss of one of the two X-chromosomes, and affects about 1 in every 2500 girls. TS patients can develop the bone disease with decreased bone density and selective reduction in cortical bone thickness, which probably contributes to the increased fracture risk. However, the mechanisms underlying the bone disease remain poorly understood. Thus, the aim of this study was to investigate the...

Evaluation of time-related changes of serum biochemical bone metabolism markers was performed in male pigs. Control group (n=7) received saline. NanoCa group (n=7) received nanopartical calcium per os (Ace Nano Calcium, NanoTechWorld, Korea). Dex group (n=7) received dexamethasone (1 mg/kg/48 hr i.m.). NanoCa/Dex group (n=6) received simultaneously nanopartical calcium and dexamethasone the same as the groups NanoCa and Dex...

Background: Breast cancer clinical trials have shown an enhanced anti-tumour activity of bone-targeted agents in postmenopausal patients. We have reported that zoledronic acid (ZOL) decreases serum levels of the tumour promoter follistatin in postmenopausal women and also inhibits expression of follistatin by breast tumour cells both in vitro and in vivo. We hypothesised that inhibin-A (InA) and ZOL may be altering bone levels of follistatin and its bound tum...

The aim of the study was to evaluate time-related changes in serum concentration of bone tissue metabolism markers in Polish Large White male pigs. At birth, the piglets were divided into four groups. The first control group (n=7) received physiological saline i.m. (placebo). The second group (NanoCa group; n=7) were administered p.o. with nanopartical calcium (Ace Nano Calcium, NanoTechWorld, Pohang, Korea). The third group (Dex group; n=7) received...

Glucocorticoids (GC) are effective drugs in the treatment of inflammatory diseases, including various forms of arthritis. However, their use is limited by negative effects on bone mass and strength, resulting in increased osteoporotic fractures. Conditional knockout mice demonstrated that the GR in osteoblasts is essential for GC-dependent bone loss. Recent studies show that GC profoundly inhibit Wnt signaling by stimulating the expression of Wnt antagonists such as dickkopf-1...

Introduction: Rheumatoid arthritis is the most common inflammatory arthritis. It is also an autoimmune disease. It’s immunological profile is typical and often correlated with clinical presentation. If acticorps anti-CCP and rheumatoid factor are part of the diagnostic criteria. Anti-nuclear antibody are found in 15–40%.Objectives: Studying the immunological profile in 110 patients treated for rheumatoid arthritis.Materie...

Epidemiological and experimental data indicates that cadmium creates a risk of bone damage even at low exposure. Our recent findings suggest that this heavy metal may affect bone via destroying the receptor activator of nuclear factor (NF)-κβ (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) system balance that plays a key role in the regulation of bone metabolism. The aim of this study was to investigate whether low-level exposure to cadmium, corresponding to low lif...