Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp235 | Osteoporosis: evaluation and imaging | ECTS2014

The impact of vitamin D and calcium intake on estimated bone stiffness as assessed by multisite quantitative ultrasound: the Canadian Multicentre Osteoporosis study

Hanley David , Brown Jacques , Adachi Jonathan , Davison Kenneth , Olszynski Wojciech

This investigation sought to assess the relationship between vitamin D and calcium intake and estimated bone stiffness as assessed by multisite quantitative ultrasound (mQUS) in a large cohort. A total of 1177 men and 2949 women were assessed with mQUS (Beam-Med Omnisense quantitative ultrasound; Isreal) at the distal radius, tibia, and phalanx sites as part of the Canadian Multicentre Osteoporosis Study (clinical sites included Saskatoon, Calgary, Hamilton, Quebec City, Halif...

ba0005oc2.5 | Bone mass and bone strength Wnt signalling | ECTS2016

Is circulating sclerostin an endocrine modulator of bone mass?

Kulkarni Rishikesh , Schindeler Aaron , Croucher Peter , Little David , Baldock Paul

Mechanosenstitive osteocytes in bone supress the local production of sclerostin in response to mechanical loading, to increase osteoblast differentiation and bone mass. In addition, sclerostin is secreted from osteocytes into the circulation. Serum sclerostin has been shown to correlate with osteoporosis and low bone mass, however there is limited evidence by which to determine whether serum sclerostin is acting either a biomark...

ba0005p190 | Cell biology: osteoclasts and bone resorption | ECTS2016

Identification and characterisation of vesicles in resorbing osteoclasts using electron tomography

McDermott Emma , Sunderhauf David , Mackenzie Kevin , Wilkinson Debbie , Helfrich Miep

Osteoclasts are the only cell type capable of resorption of mineralised matrix such as bone or dentine. Resorbing osteoclasts form distinct membrane domains: the functional secretory, the basolateral and the ruffled border (RB) domains. The RB allows acidification of the resorption lacuna, exocytosis of osteolytic enzymes and uptake of degraded bone material, processes that require directed vesicular transport. Few studies have tried to classify the vesicles near the RB into s...

ba0005p369 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Osteoporosis-related knowledge and health beliefs among female community leaders in Peru

Sava Mihaela , Hsieh Evelyn , Garcia Patricia , Mabey David

Background: Postmenopausal women are at high risk for osteoporosis, and early adoption of osteoporosis-preventative behaviours, such as physical activity and dietary calcium intake, can help mitigate this risk. Behavioural studies have shown that knowledge and health beliefs are key factors associated with adoption of healthy behaviours. There are few such studies regarding osteoporosis in South America. Our aim was to conduct an exploratory study evaluating osteoporosis-relat...

ba0005p475 | Paediatric bone disease | ECTS2016

Validation of a novel scoring system, the radiographic global impression of change (RGI-C) scale, for assessing skeletal manifestations of hypophosphatasia in infants and children

Whyte Michael , Fujita Kenji , Moseley Scott , Thompson David , McAlister William

Hypophosphatasia (HPP) is the rare inherited metabolic disease caused by loss-of-function mutations in the tissue-nonspecific alkaline phosphatase (TNSALP) gene. TNSALP deficiency leads to extracellular excess of inorganic pyrophosphate, a bone mineralization inhibitor. Here, we report the validity and reproducibility of a novel scale to quantify HPP-specific radiographic changes in pediatric patients.The Radiographic Global Impression of Change (RGI-C) ...

ba0006p054 | (1) | ICCBH2017

The influence of immune dysregulation on bone metabolism in children with inflammatory bowel disease: the potential for bone as a secondary lymphoid organ

Penman Gareth , Campbell David , Pockley A. Graham , Bishop Nicholas

The influence of immune dysregulation on bone metabolism in children with inflammatory bowel disease: the potential for bone as a secondary lymphoid organ.Background: Whilst their clinical relevance in terms of fracture may be questioned, systemic inflammatory disorders in children impacts on their bone metabolism and reduces bone mineral density. Similar observations in adults are in part explained by interactions between lymphocytes and osteoclasts via...

ba0007p11 | (1) | ICCBH2019

Reference values of cortical thickness, bone width, and Bone Health Index in metacarpals of children from age 0 y, as determined with an extension of the fully automated BoneXpert bone age method

Thodberg Hans Henrik , Thrane Peter , Martin David D.

Objective: The BoneXpert method for automated bone age determination from hand X-rays also determines the cortical thickness T and the bone width W in the three middle metacarpals. From these, the method derives the cortical area A=π W T (1 – T/W), the metacarpal index MCI =A/(WW) and the Bone Health Index. Recently, the method has been extended down to new-borns, and the aim of this study is to report reference curves for these bone measures.M...

ba0007p93 | (1) | ICCBH2019

Assessing the ability of vibration analysis to differentiate wrist and ankle fractures from sprains in children

Fennimore David , Ali Ridita , Alboul Lyuba , Offiah Amaka

Rationale and Hypothesis: Standard practice for differentiating fractures from sprains requires conventional radiographs. Up to 21% of wrist and ankle radiographs in children are negative at a local cost of over £100,000 per annum, approximately £12 million per annum across England and Wales. Our recent pilot study in adults confirmed that vibration analysis in injured patients causes no discomfort.Objectives: To assess the ability of vibration...

ba0001pp128 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2013

Mass spectrometric immunoassay for intact parathyroid hormone: correlation with immunoassay and application to clinical samples

Couchman L , Taylor D , Krystans B , Lopez M , Prakash A , Sarracino D , Garces A , Vogelsang M , Peterman S , Vadali G , Robinson S , Moniz C

Introduction: Parathyroid hormone (PTH) measurement is of use in i) differential diagnosis of hypercalcaemia and ii) patients with renal impairment at risk of bone disease. PTH immunoassays are complicated by cross-reactivity with truncated (inactive) variant forms, which accumulate in patients with renal impairment. PTH assay variability is a critical governance issue in renal medicine, suggesting an MS-based reference method is required.Aim: To develop...