Bone Abstracts

Age is one of the most important factors that influence bone condition. At the age of 40–45 years for women (F) and 50 years for men (M) processes of bone formation and resorption are balanced, then bone resorption predominates.We examined 103 M (20–78 years) and 360 F (20–87 years), residing in the Republic of Karelia. Densitometry was performed for all patients to assess age-related changes in bone mineral density (BMD) at the lumbar spi...

There are few cases of pregnancy described in which the fetus was exposed to some bisphosphonates, but not ibandronate to our knowledge. Meanwhile, ibandronate has a high protein binding rate (87%) and short tissue’s half-life (24 days) and might be a less potentially harmful drug in the event of pregnancy.A 23-year-old woman was admitted to our hospital with evident ACTH-dependent Cushing’s syndrome CS (24 h urinary free cortisol – 2413 n...

see PP178....

Bone-marrow mesenchymal stem cells (MSCs) are the origin of bone-forming cells with immunomodulation potential. Among the generated immunosuppressive molecules there is HLA-G5. HLA-G proteins play a crucial role in promoting the acceptance of allografts. However, the mechanisms regulating the expression of HLA-G5 in human MSCs are unknown. We induced differentiation of human MSCs (harvested from iliac crests of healthy volunteers after their informed consent following approved...

Caffeine is a methylxanthine found in many foods and is widely consumed by the human population. Therefore, its effects and mechanisms in various tissues have been widely studied. But despite changing the postnatal bone growth, there are few studies about its effect on growth cartilage. The objective of this study was to evaluate the In vitro effects of caffeine on proliferation, apoptosis and gene transcripts expression of chondrogenic differentiation in growth carti...

Despite the presence of skeletal anomalies in fetuses of female rats treated with caffeine, their effect on bone’s formation and growth have not yet been elucidated. The objective of this study was to evaluate the effects of caffeine on the formation and endochondral bone growth in rats. There had been used 36 Wistar rats distributed among the control group and others treated with caffeine at doses of 25, 50, and 100 mg/kg. Treated groups received caffeine daily throughou...

Glucocorticoids are the most commonly used drugs in medical therapy, released in stress and necessary for normal development in both humans and animals.The aim of this study was to investigate the effect of prenatally administered dexamethasone (Dex), a synthetic glucocorticoid, on the histomorphometry of the femur in the offsprings of spiny mice, as a precocial species, characterized by high fertility, and the rapid development of the fetal, allowing th...

Alterations in fetal nutrition result in developmental adaptations that permanently alter the structure, physiology and metabolism of the offspring. β-hydroxy-β-methylbutyrate (HMB) is the bioactive metabolite of leucine responsible for inhibiting proteolysis and for modulating protein turnover in vitro and in vivo.The aim of the study was to determine the effect of maternal administration with HMB on mineralization, geometry ...

Caffeine is a methylxanthine found in many foods and is widely consumed by the human population. Therefore, its effects and mechanisms in various tissues have been widely studied. Various bone abnormalities have been observed in fetuses from rats treated with caffeine. But the genesis of these abnormalities is not known. The objective of this study was to verify the metabolism and activity of calvaria osteoblasts from offspring of rats treated with caffeine during pregnancy. T...

Tea is the second most consumed beverage in the world, next to water. The popularity of tea is determined by healthy properties connected with the presence of antioxidants, hence tea can be classified as functional food. Cadmium (Cd) and lead (Pb) are toxic metals commonly occurring in the human environment with exposure ~5 and 35 mg/kg Bw per week respectively.Thirty growing male Wistar rats (12 weeks old, 326.4±31.0 g) were used. Rat were fed ...