Bone Abstracts

Biographical DetailsMichael D Briggs obtained his PhD at the MRC Clinical Research Centre, Harrow, studying the genetic basis of osteogenesis imperfecta. He undertook postdoctoral work at UCLA identifying the genetic basis of chondrodysplasias. In 1996 Mike moved to Manchester as an AR-UK Fellow to continue studying disease mechanisms in chondrodysplasia. In 2004 he was awarded a Wellcome...

Objectives: Young male jockeys undertake calorie restriction and high volumes of physical activity during periods of musculoskeletal growth and development. Previous research shows that jockeys have compromised bone health1–4 and display disordered eating5–7. Restricted intakes of calcium and vitamin D, together with excessive amounts of exercise, increase the risk of osteoporosis in males8. The aim of this study was to establish whet...

Background: A 3 month-old boy was born at term, to non-consanguineous parents by spontaneous vaginal delivery, in good condition, weighing 4.19 kg. Newborn examination, including eyes, was normal prior to discharge. He has two older brothers in good health.Presenting problem: He was admitted at 7 days of life with focal seizures and hypocalcaemia (1.5 mmol/l), hypomagnesaemia (0.6 mmol/l), hyperphosphataemia (3.7 mmol/l) and inappropriately low parathyro...

Patients with osteoporosis require treatment with therapies that reduce the risk of fracture which at the spine is significantly influenced by bone microarchitecture. Quantitative computed tomography (QCT) and dual X-ray absorptiometry (DXA) allow measurement of bone mineral density (BMD), a known indicator of fracture risk. Trabecular bone score (TBS) is a novel gray-level measurement derived from spine DXA image texture that is related to microarchitecture and associates wit...

In sharp contrast to the great interest in morphology of the proximal femur in aged individuals, there is a paucity of studies in children. To date, a comprehensive quantitative analysis of trabecular micro-architecture in various biomechanically relevant subregions of the immature proximal femur has been lacking. The aim of this study was to characterize postnatal development of trabecular bone in various regions of the human proximal femur. The study sample was comprised of ...

Habitual physical activities of past populations are frequently reconstructed based on musculoskeletal markers (MSM) in human skeletal remains, i.e. particular morphological features of muscles attachment sites. However, the relationship between muscular activity and bone microstructure at the site of muscle attachments is unexplored. Therefore, this study aimed at analyzing bone microstructural characteristics of the muscles attachments sites and correlating these features wi...

Success in periodontal regeneration through guided tissue regeneration relies on the healing capacity of the host tissue. Platelet preparations are mitogenic and stimulate regeneration through high growth factor levels. Here we assessed collagen barrier membranes (CBM) as carriers for the secretome of activated platelets. We evaluated cell-attachment, the release of the secretome, and cell proliferation.Secretome of washed platelets (washed PSEC) and unw...

Temporary brittle bone disease has been a controversial explanation of multiple unexplained fractures in early childhood. Evidence for its existence is growing. We report the clinical and laboratory features of 104 patients investigated personally. These patients had in aggregate 984 fractures or fracture-like lesions.Our patients included disproportionate numbers of infants born preterm or as a result of multiple pregnancy. The fractures were mainly ide...

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Objective: Childhood onset Crohn’s disease (CO-CD) is associated with musculoskeletal deficits. However, there are limited data regarding muscle-bone outcomes in adults with CO-CD. The current study aimed to comprehensively assess the muscle-fat-bone unit in young adults with CO-CD, using novel methods of MRI, in comparison with healthy controls.Methods: Trabecular microarchitecture and cortical geometry of the distal femur were assessed using 3T mi...