Bone Abstracts

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There have been considerable advances in our knowledge of how loss of androgens signalling leads to bone loss in aging male with hypogonadism. However, the roles of androgen actions on the skeletal growth remain limited. Recently, new insights into the function of and androgen receptor (AR), learned from human genetic mutations and gene targeting mouse models have contributed to emerged understanding of the androgenic effects on bone and cartilage in health and diseases. Here,...

Purpose: The aim of this research was to develop an in vivo platform for conveniently examining the potential of various factors to augment chondral bone regeneration. For this purpose, we have established a de novo partial tail amputation model in adult zebrafish, which includes the resection of cartilage-template based bones from the endoskeletal caudal complex. Endoskeletal amputations were rarely studied, as opposed to those of the distal caudal fin rays, a well-e...

Background: WHO recommends diagnostic criteria of osteoporosis can be based on double energy absorption of x-ray bone densitometry (DXA), but the DXA method has some limitations such as relatively higher cost, relatively longer detection time, inconvenience in equipment transportation and so on. Quantitative Ultrasound (QUS) method has the potential to diagnose osteoporosis and it is convenient to carry around and low-cost. Asian osteoporosis self-assessment tool (OSTA) is an ...

Objective: To analyse the influential factors of lifestyle on vitamin D status among aged people in Shanghai community.Method: Lifestyles of 3846 elderly men and women aged over 65 years were investigated using a self-designed questionnaire from ten communities of urban and suburb in Shanghai China, which contained sociodemographic factors and lifestyle factors and so on. The levels of serum 25(OH)D were measured by Cobas Diagnosis System of Roche. Univa...

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Treatment with sclerostin antibody (Scl-Ab) increases bone formation and strength in animal models. Here, we aimed to i) characterize the longer-term effects of Scl-Ab on bone in cynomolgus monkeys (cynos) and ovariectomized (OVX) rats and ii) test whether follow-up treatment with OPG-Fc would maintain the bone mass gains induced by Scl-Ab in OVX rats. In the cynos study, 3 to 5-year-old male cynos were treated for 6 months with weekly SC injections of vehicle (Veh), 3, 10, or...

Objective: To estimate the proportion of patients who experienced cardiovascular (CV) events or were at risk for CV events prior to initiation of strontium ranelate among osteoporotic (OP) patients.Methods: This was a retrospective database analysis using the Clinical Practice Research Datalink (CPRD) database. Patients were included if they had ≥1 prescription (Rx) of strontium from 9/1/2008 to 8/31/2013, were aged ≥50 years as of the index ...

Chronic stress and depression are associated with alterations in the hypothalamic–pituitary–adrenal signalling cascade and considered a risk factor for bone loss and fractures. However, the mechanisms underlying the association between stress and poor bone health are unclear. Utilising a transgenic (tg) mouse model in which glucocorticoid signalling is selectively disrupted in mature osteoblasts and osteocytes (HSD2OB-tg mice), the current study examines t...

Introduction: Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic syndrome which is usually induced by mesenchymal tissue tumor with excessive secretion of FGF23. The misdiagnosis of TIO is frequently seen in clinic. Therefore, this study is aimed to describe the misdiagnosed situation of TIO, explore the possible underlying reasons for missed diagnosis and misdiagnosis through the analysis of 144 TIO patients, and improve clinicians’ awareness of TIO.<...