Bone Abstracts

Objectives: Bone remodeling and maintenance require a fine balance between bone formation of osteoblasts and resorption of osteoclasts. Therefore, various skeletal disorders cause by imbalanced differentiation and activities of these cells. Receptor activator of NF-κB ligand (RANKL) induces Ca2+ oscillations and activates nuclear factor of activated T cells 1 (NFATc1) during osteoclast differentiation. Although Ca2+ oscillations play a key role for o...

Many reports have proposed significant role of vitamin D on immune mediated disease. This study analyzed lymphocyte subsets according to serum 25(OH) vitamin D levels in postmenopausal women to determine the potential effect of vitamin D on immune-mediated disease.On a prospective observational basis, we enrolled 31 postmenopausal women who underwent health checkup in our hospital. Peripheral blood drawn for the estimation of total T, B cell, NK cell cou...

Objective: We aim to investigate gender similarities and differences in femoral neck (FN) structure of elderly population by bone investigational tookit (BIT) of quantitative computed tomography (QCT).Material and methods: This cross-sectional study was part of China Action on Spine and Hip Status study, including 207 males aged 55–87 years and 400 females aged 55–96 years. QCT scans were performed in the hip for the subjects, and we used BIT s...

Objective: Individuals with type 2 diabetes have increased fracture risk despite higher bone mineral density (BMD). There are few studies regarding the effect of diabetes on bone mineral density and hip geometry in Asian population. The aim of this study was to examine the gender-specific influence of diabetes on BMD and hip geometry.Subjects and methods: A total of 1334 subjects (571 men and 763 women) ≥50 years of age were analyzed using data fro...

Autogenous bone graft has been used in the treatment of a fracture, non-union, and bone defect. However, bone graft substitutes have been developed and used because of the limited amount or donor site morbidity of the autogenous bone graft. Many kinds of bone graft substitutes including osteoconductive materials and osteoinductive materials are used for improving bone healing. Osteoconductive materials help to provide a three-dimensional structure to support the ingrowth of th...

Calcium and vitamin D are essential components for bone health, thus calcium and vitamin D supplementation is an important strategy in the management of osteoporosis.However, the benefit of calcium and vitamin D supplementation on bone health is still controversial. Moreover, potentially harmful effects of excessive calcium supplementation on cardiovascular health are recently suggested. Too high a level of vitamin D has been also reported to have severa...

Background: Both osteoporosis and tooth loss are major health problems that are frequently observed in postmenopausal women. Authors in this study investigated the relationship between low bone mineral density and edentulism.Methods: This cross-sectional study used data from the fifth Korea National Health and Nutrition Examination Survey 2011–2012. A total of 2129 postmenopausal women (50–80 years), who had bone mineral density measured and ha...

The osteocyte most likely plays a role in bone remodeling by instructing osteoclasts to remove bone at specific sites. This entire process includes recruitment, proliferation and differentiation of osteoclast precursors. And osteocytes are responsible for detecting and responding to mechanical strain and may send signal to other cells. Therefore, to determine the role for osteocytes and mechanical strain in bone remodeling, we examined the effect of steady or pulsatile shear s...

Objectives: There are some studies that evaluated changes of bone marrow density (BMD) and re-fracture after zoledronic acid injection. However, there is no study that showed about the fracture on all of the body, fracture healing, and improvement of clinical symptom after zoledronic acid injection. In this study, authors evaluated the 1-year BMD change, changes of lumbar pain in lumbar spine fractures, effects on fracture healing, re-fracture and additional fracture on other ...

Prostate cancer is a commonly diagnosed malignancy in Europe. Bone is one of the common metastasis sites. There is increasing evidence for estrogen involvement in the prostate tumorigenesis. ERβ knockout (BERKO) mice have been reported to have anti-proliferative, anti-inflammatory and potential anti-tumorigenic functions of ERβ. However, prostate phenotype of BERKO mice has been under debate.The potential effect of ERβ on prostate tumorgen...