Bone Abstracts

Bone remodeling and maintenance require a fine balance between bone formation of osteoblasts and resorption of osteoclasts. Therefore, various skeletal disorders cause by imbalanced differentiation and activities of these cells. RANKL (receptor activator of NF-kB ligand) induces Ca2+ oscillations and activates NFATc1 (nuclear factor of activated T cells i) during osteoclast differentiation. Although Ca2+ oscillations play a key role for osteoclastogenesis...

The P2Y14 (purinergic receptor P2Y, G protein coupled, 14) receptor for UDP-glucose and other UDP-sugars has been implicated in the regulation of the stem cell compartment as well as neuroimmune function. However, the role of P2Y14 in osteoclast formation is completely unknown. We found that RANKL selectively induced P2Y14 among seven mammalian P2Y receptors when analysed at both the mRNA and protein level, but inhibitors of the MAP pathway suppressed induction of P2Y14 protei...

There are several evidences that osteocyte plays a critical role in bone remodeling. Healthy or apoptotic osteocytes can send signals to other bone surface cells like osteoblasts, osteoclasts, osteoclast precursors and bone lining cells through their networking in canaliculi. Therefore, to determine the role for osteocytes in bone remodeling, we examined the effect of healthy and apoptotic osteocytes on osteoblasts proliferation and recruitment. In addition, the effects of mec...

Objectives: This study was designed to investigate the prevalence of low bone mass, the influence of amenorrhea on bone mineral density (BMD), and the cause of amenorrhea that provoke the severe low bone mass in premenopausal women.Materials and methods: One hundred and seventy one women diagnosed with amenorrhea in premenopausal women were included in this study. All patients underwent history taking, gynecological examination, and check serum hormone l...

Background: Familial hypocalciuric hypercalcemia (FHH) is a rare autosomal dominant condition with an estimated prevalence of 1 in 78,000. The commonest cause of FHH is inactivating mutations of the calcium-sensing receptor (CASR) gene, with the rest mostly caused by missense mutations of the GNA11 and AP2S1 genes. FHH is characterized by persistent mild-to-moderate hypercalcemia, hypocalciuria with calcium-creatinine clearance ratio ⩽0.01. The disease runs a benign cou...

Bisphosphonates (BPs) are widely used for treating osteoporosis and preventing osseous metastasis or hypercalcemia in cancers. However, osteonecrosis of the jaw in patients treated with BP after dentoalveolar surgery has been increasing, especially in those treated with strong BPs such as zoledronate (ZA). The pathobiology underlying the occurrence of osteonecrosis only in the jaw bone remains unclear. The objective of this study was to compare the effects of BPs on the in...

Osteoporosis is known to be associated with metabolic diseases characterized by insulin resistance, such as central obesity, diabetes, and metabolic syndrome. Non-alcoholic fatty liver disease (NAFLD) is also increased in such insulin resistant conditions. However, little is known about whether osteoporosis and nonalcoholic fatty liver disease are etiologically related to each other or not. We investigated whether bone mineral density(BMD) is associated with NAFLD in pre- and ...

Purpose: Osteoporosis is a progressive bone disease that is characterized by a decrease in bone mass, density and destruction of microstructure, which can lead to an increased risk of fracture. Although many studies have been published about relationship between end-stage renal disease and osteoporosis, but research on the relationship between proteinuria and the prevalence of osteoporosis is still lacking.Methods: We assessed 91 postmenopausal women wit...

Objectives: There are some studies that evaluated changes of bone marrow density (BMD) and re-fracture after zoledronic acid injection. However, there is no study that showed about the fracture on all of the body, fracture healing, and improvement of clinical symptom after zoledronic acid injection. In this study, authors evaluated the 1 year BMD change, changes of lumbar pain in lumbar spine fractures, effects on fracture healing, re-fracture and additional fracture on other ...

Objectives: Quadriplegic children are more susceptible to osteoporosis because of various risk factors for the inhibition of bone metabolism. The importance of bone metabolism is being emphasized based on extending life span of the patients but research on this area is insufficient. Intravenous (IV) pamidronate is well known as an effective treatment for pediatric osteoporosis, but there are no treatment guidelines for accurate dose capacity and duration in quadriplegic childr...