Bone Abstracts

Introduction: Acute vertebral compression fractures cause severe back pain and need long time to heal. The progression of fracture or nonunion is not rare. The teriparatide is a synthetic parathyroid hormone which has been used as anabolic agent and treatment of osteoporosis. It can also be used for promoting fracture healing in special condition. Periodic infusion of teriparatide enhances bone formation and increases bone strength. We evaluated the effect of periodic teripara...

Autogenous bone graft has been used in the treatment of a fracture, non-union, and bone defect. However, bone graft substitutes have been developed and used because of the limited amount or donor site morbidity of the autogenous bone graft. Many kinds of bone graft substitutes including osteoconductive materials and osteoinductive materials are used for improving bone healing. Osteoconductive materials help to provide a three-dimensional structure to support the ingrowth of th...

Calcium and vitamin D are essential components for bone health, thus calcium and vitamin D supplementation is an important strategy in the management of osteoporosis.However, the benefit of calcium and vitamin D supplementation on bone health is still controversial. Moreover, potentially harmful effects of excessive calcium supplementation on cardiovascular health are recently suggested. Too high a level of vitamin D has been also reported to have severa...

Objective: The purpose of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in leptin (LEP), its receptor (LEPR) and β adrenergic receptor (ADRB) genes and bone mineral density (BMD) in postmenopausal Korean women.Methods: The LEP c.280G>A, LEPR c.326A>G, c.668A>G, c.1968G>C, c.2096C>T, ADRB2 c.46A>G, c.79C>G, c.718T>C, c....

Background: Both osteoporosis and tooth loss are major health problems that are frequently observed in postmenopausal women. Authors in this study investigated the relationship between low bone mineral density and edentulism.Methods: This cross-sectional study used data from the fifth Korea National Health and Nutrition Examination Survey 2011–2012. A total of 2129 postmenopausal women (50–80 years), who had bone mineral density measured and ha...

Objectives: There are some studies that evaluated changes of bone marrow density (BMD) and re-fracture after zoledronic acid injection. However, there is no study that showed about the fracture on all of the body, fracture healing, and improvement of clinical symptom after zoledronic acid injection. In this study, authors evaluated the 1-year BMD change, changes of lumbar pain in lumbar spine fractures, effects on fracture healing, re-fracture and additional fracture on other ...

Inflammatory processes play a role in osteoclastogenesis. C-reactive protein (CRP), an acute phase reactant that reflects different degree of inflammation. More recently, accumulating evidence suggest that CRP is not only an inflammatory marker but also direct cause of diseases. Therefore, we examined the direct effects of CRP on osteoclast formation using RAW 264.7 cells. CRP significantly inhibited RANKL-induced TRAP-positive multinucleated cell formation in RAW 264.7 cell c...

We previously elucidated that β-adrenergic blockade attenuates high fat diet induced obesity development and such an effect is associated with suppressed pancreatic lipase (PNLIP) expressions. In the present study, we tested whether β-adrenergic blockade downregulates bioactive osteocalcin secretion in osteoblasts, thereby reduces PNLIP secretion in pancreatic acinar cells.Forty of male 6wk old C57BL/6 mice were assigned into control diet (CON)...

Better quality of cartilage repair in developing skeleton is recognized. The associated repair factors may be important in osteoarthritis and those factors would be the targets for the management of osteoarthritis. Microarray analysis of cartilage repair in rat knee joint was therefore carried out. Surgical injury on the femoral cartilage of the right patello-femoral joint in the 3- and 8-week-old rats for 2 weeks was first made. The left side of joint cartilage was used as th...

Gene deletion or treatments with a cathepsin K (CatK) inhibitor in mature preclinical models result not only result in lower bone resorption but also in higher bone formation (BF) on both remodeling and modeling surfaces. Although increased production of clastokines and matrix-derived growth factors may explain the increased BF at remodeling surfaces, the mechanisms for greater BF at modeling surfaces, including the periosteum, remain unexplained. We hypothesized that the abse...