Bone Abstracts

Objective: Bone is one of endocrine organ and osteocytes secretes FGF23, Sclerostin and DKK1. FGF23 inhibits renal phosphate reabsorption and suppresses 1-α hydroxylase activity. Calcitriol stimulates FGF23 synthesis in bone. We aimed to determine the effect of single bolus injection of vitamin D on serum FGF23, DKK1 and Sclerostin concentrations in vitamin D-deficient subjects.Design and methods: The study group was composed of placebo group with s...

Objective: Individuals with type 2 diabetes have increased fracture risk despite higher bone mineral density (BMD). There are few studies regarding the effect of diabetes on bone mineral density and hip geometry in Asian population. The aim of this study was to examine the gender-specific influence of diabetes on BMD and hip geometry.Subjects and methods: A total of 1334 subjects (571 men and 763 women) ≥50 years of age were analyzed using data fro...

Introduction: This study aims to assess 25-hydroxyvitamin D—25(OH)D—status in perimenopausal women to analyze its relationships with serum PTH levels and bone mineral density (BMD).Methods: A total of 102 individuals who visited to climacteric clinic in Sanggye paik hospital participated in the study. Serum 25(OH)D and intact parathyroid hormone (PTH) were measured. BMD was determined by dual x-ray absorptiometry (DXA) at lumbar spine, femoral ...

Objective: We analyze changes of spine BMD and hip BMD after total knee replacement (TKR) according to osteoporosis medication, bilaterality of operation site, degree of obesity, degree of knee function and osteoporosis diagnosis at operation in female patients above 65 years old, who received TKR due to severe knee osteoarthritis,Method: 52 patients who checked 1 year follow-up BMD were enrolled. Patients were checked the spine and hip BMD at pre-operat...

Introduction: The authors experienced a ipsilateral femoral stress fracture after total knee arthroplasty (TKR). Decreased bone mineral density (BMD) after TKR have been proposed as cause. However, reports regarding changes of BMD in the proximal hip after TKR have been rare. Therefore, first, we studied the question of whether TKR can effect change of proximal hip BMD? Second, if so, does TKR have different effects on BMD of the operative and non-operative sides?<p class=...

Objectives: Vitamin D dependent rickets type I (VDDR-I) is an autosomal recessive disorder with impaired activation of vitamin D, caused by mutations in CYP27B1. Characteristic clinical features are hypotonia, muscle weakness, growth failure, hypocalcemic seizures in early infancy, and radiographic findings of rickets. We aimed to describe the clinical and laboratory findings in a VDDR-1 case and to report a mutation in CYP27B1.Methods and results: The p...

Background: Vitamin D status is associated with bone health. Vitamin D deficiency leads to decreased bone formation and increased bone resorption. 25-hydroxyvitamin D (25(OH) D), parathyroid hormone (PTH) levels in children could affect bone turnover, and in turn, the bone markers should reflect vitamin D condition. In children the relationships among 25(OH) D, PTH and bone turnover markers are remain.Objective: To explore the associations among serum 25...

Purpose: Risk factors for intertrochanteric fracture (IF) severity were not studied thoroughly despite the high failure rate of osteosynthesis. The purpose of this study was to identify the risk factor for each fracture type using AO/OTA classification in elderly female patients who experienced IF.Materials and methods: This retrospective study identified 240 women over 50 years old with an incident IF in whom dual-energy x-ray absorptiometry (DEXA) was ...

Mutations in PLEKHM1 cause bone disease in humans and animals. Truncations causedeficient bone resorption by osteoclasts leading to osteopetrosis. A gain-of-function point mutation causes increased resorption leading to osteopenia. We and others have shown that PLEKHM1, a multi-modular protein, interacts with the small GTPase rab7 and is involved in vesicle trafficking, secretion, and membrane biogenesis. To investigate other interactions of PLEKHM1 we performed tandem affinit...

The purpose of this study was to investigate the effects of fitness program with vitamin D supplementation for biochemistry related to vitamin D, muscle mass and physical functions in elderly women.The subjects were elderly women aged 65 or older, regularly visiting a senior welfare center and a senior citizen center in city. A total of 65 subjects were divided into experimental group (n=34) and control group (n=31). The intervention fo...