Bone Abstracts

Introduction: Optimal 25(OH)D serum level is very important for bone health and calcium–phosphate homeostasis as well as for optimal function of many organs and tissues. The consequences of vitamin D deficiency are mineralization defects, which may lead to osteomalacia in the long-term, and muscle weakness, causing falls and fractures.Objectives: The aim of the research is to determine the frequency of vitamin D deficiency and it’s influence on...

Aim: Periodontologists all over the world are more and more interested in connection between pathogenesis of aggressive periodontitis (AP) and calcium and vitamin D metabolic disturbances. Vitamin D besides its direct effect on calcium homeostasis, has immunomodulatory action, that makes interesting the study of vitamin D effect on pathogenesis of AP.Materials and methods: We studied 102 (49 males; 53 females) patients with AP (40.32±1.13), 42 patie...

Objective: Transfusion dependent thalassemia (TM) patients have routinely been placed on vitamin D supplementation due to their increased risk of osteoporosis, as well as their high rates of vitamin D deficiency (serum 25 hydroxyvitamin D (25-OHD) <11 ng/ml) and insufficiency (25-OHD <30 ng/ml). Furthermore, recent studies have linked 25-OHD levels to hypercalciuria and nephrolithiasis in TM. The objective of this study is to determine the effect of vitamin D supplemen...

There is wide variation in the dose-response to oral vitamin D and the increment in plasma 25(OH)D decreases per unit vitamin D given. We hypothesised that this is related to increased 25(OH)D catabolism as reflected in 25OHD half-life (25(OH)D3 t1/2).Design: 25(OH)D3 t1/2 was measured with a stable isotope (SI) technique in older (70y+) men and women in the UK during winter before (<...

Aim: Low serum vitamin D levels are common in sunny Lebanon. Vitamin D is essential component of osteoporosis management strategies. This study surveys the referral rate of Lebanese males for vitamin D testing.Subjects and methods: A 13 000 Lebanese subjects included in this study were coming for routine check-ups. Patients on renal dialysis and cancer patients on chemotherapy were excluded. Serum 25-hydroxy vitamin D is considered the best indicator of ...

Vitamin D deficiency is common in older persons and non-western immigrants. Vitamin D is often started in loading doses of 50 000 IU/ml solution. Though, generally considered safe, this highly concentrated solution carries some risks as is illustrated by the following cases. A woman of >80 years old was admitted with hypercalcemia, calcium 3.27 mmol/l. She complained of nausea, thirst and polyuria for 3 months. History included cholecystitis, atrial fibrillation, myocardia...

Objective: To find whether treatment with cholecalciferol and calcium in a group of vitamin D deficient women is associated with changes in muscular function, musculoskeletal pain, and fatigue.Design: Prospective interventional cohort study.Sample: A study group of 25 post partum women recruited and diagnosed with hypovitaminosis D during pregnancy.Setting: The study group was recruited 2006–2009 at two ...

Background: Improving the general population’s vitamin D status through food fortification is part of an ongoing international debate. Vitamin D status during pregnancy may influence the long-term bone health of the offspring; yet conflicting results have been reported and none of the studies have examined paediatric fracture as outcome.Method: The influence of extra vitamin D exposure during prenatal life and risk of fracture during adolescence was...

Classical vitamin D biology relates the active hormone, 1,25-dihydroxvitamin D3, to promotion of calcium homeostasis through actions on the intestine and bone, and regulation of parathyroid hormone production and release. Added to this classical action of vitamin D is the up-regulation of FGF23 production and release by osteocytes as a means of regulation of circulating levels of vitamin D by reducing kidney synthesis of 1,25-dihydroxvitamin D3 and increa...

Pathologist Christian Georg Schmorl described a specific type of vertebral lesion, which is now known as Schmorl’s node. A Schmorl’s node or intradiscal herniation is herniation of nucleus pulposus through the cartilaginous and bony end plate into the body of an adjacent vertebra. Schmorl nodes are seen primarily in the thoracolumbar spines in an elderly population. Schmorl nodes are associated with moderate but not advanced degenerative changes. An 11-year-male pres...