Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp476 | Other diseases of bone and mineral metabolism | ECTS2013

multidisciplinary studies of ancient calcified tissues II: contents from Egyptian canopic jars

Rucci Nadia , Arrizza Lorenzo , Capulli Mattia , Maurizi Antonio , Mercurio Cinzia , Guidotti Maria Cristina , Fornaciari Gino , Teti Anna , Ventura Luca

Ancient Egyptians were well known for the art of embalming, performed in the belief that preservation of the body was essential for survival in the afterlife. During the mummification process, internal organs were removed and some of them (lungs, stomach, liver, and intestines) washed, dehydrated with natron, perfumed, and stored in so-called canopic jars, buried with the mummy. Each jar had established contents and its own protective deity. To date, a limited number of studie...

ba0003cc1 | (1) | ECTS2014

Molecular diagnosis of osteopetrotic patients with atypical presentations using traditional approaches and exome sequencing

Palagano Eleonora , Pangrazio Alessandra , Strina Dario , Puddu Alessandro , Oppo Manuela , Valentini Maria , Vezzoni Paolo , Villa Anna , Sobacchi Cristina

Autosomal Recessive Osteopetrosis (ARO) presents early in life with extreme sclerosis of the skeleton, reduction of bone marrow spaces, hepatosplenomegaly, cranial nerves compression and severe growth failure. ARO is often lethal and at present the only therapy is HSCT, which should be performed as soon as possible in order to obtain a major benefit. ARO is genetically heterogeneous and delays in clinical diagnosis sometimes occur, due to its rareness and to the presence of co...

ba0003pp222 | Osteoporosis: evaluation and imaging | ECTS2014

Association of CT-based finite element estimates of femur strength with fracture status in three clinical studies on post-menopausal women

Schileo Enrico , Falcinelli Cristina , Balistreri Luca , Henys Petr , Baruffaldi Fabio , Sigurdsson Sigurdur , Gudnason Vilmundur , Boutroy Stephanie , Taddei Fulvia

Introduction: The first clinical applications of FE-strength estimates to classify osteoporotic fractures showed inhomogeneous results. We developed a FE model that correlated well with femur strength in-vitro (R2=0.9, 14 femurs). This work aims to verify if our model can classify osteoporotic fractures in three case-control studies: a retrospective and a prospective study on proximal femur fracture, and a retrospective study on prevalent ...

ba0003pp250 | Osteoporosis: evaluation and imaging | ECTS2014

Vitamin D levels in male patients with systemic lupus erythematosus

Vergara Cristina , Martinez-Ferrer Angels , Vicens Elvira , Valls Elia , Oller Jose , De la Morena Isabel , Ybanez Desamparados , Alegre Juan Jose

Introduction: Although systemic lupus erythematosus (SLE) has traditionally been considered a disease of women, men may also be afected. Male osteoporosis is increasingly recognised. Several studies have reported that mean bone mineral density is significantly reduced in SLE women patients and most of them have low levels of vitamin D. The aim of our study is to analize this situation in men.Objectives: Determine 25-hydroxyvitamin-D (25OHD) serum concent...

ba0005p237 | Genetics and Epigenetics | ECTS2016

Association among oxidative stress, Wnt signaling and trabecular bone microstructure in osteoporosis and osteoarthritis

Giner Merce , Miranda Cristina , Jose Montoya M. , Portal Sergio , Angeles Vazquez M. , Jose Miranda M. , Esbrit Pedro , Perez-Cano Ramon

Experimental studies suggested that both, oxidative stress and the Wnt pathway, are important factors in the regulation of bone remodeling. Thus, low antioxidant levels and elevated markers of Wnt pathway inhibitors (sclerostin) levels are associated with a reduced bone mineral density and increased risk of osteoporotic fracture. Whether oxidative stress and the Wnt pathway are related to fracture risk is poorly understood.M&M: Cross-sectional study ...

ba0005p435 | Other diseases of bone and mineral metabolism | ECTS2016

Association between serum levels of PPARγ and vertebral fractures in type 2 diabetes mellitus patients

Garcia-Fontana Beatriz , Morales-Santana Sonia , Novo-Rodriguez Cristina , Rozas-Moreno Pedro , Reyes-Garcia Rebeca , Munoz-Torres Manuel

Introduction: Type 2 diabetes mellitus (T2DM) is a risk factor for the development of fractures. Several studies have shown an inverse relationship between osteoblastogenesis and adipogenesis through a competition model between these processes.PPARγ acts as regulator of adipogenesis and its increased expression is associated to decreased osteoblastogenesis. The treatment of insulin resistance with glitazones, one of the ligands of PPARγ, reduce...

ba0005p451 | Other diseases of bone and mineral metabolism | ECTS2016

Rankl−/− mesenchymal stromal cells have an unexpected osteogenic differentiation defect which is improved by a RANKL-expressing lentiviral vector

Menale Ciro , Schena Francesca , Diomede Lorenzo , Sergi Lucia Sergi , Susani Lucia , Palagano Eleonora , Traggiai Elisabetta , Sobacchi Cristina , Villa Anna

Osteoclast-poor RANKL-dependent autosomal recessive osteopetrosis (ARO) is a rare bone disease characterized by an increase in bone density due to the failure of bone resorption by impaired osteoclast formation. Haematopoietic stem cell transplantation is not an effective therapy for this ARO form, since in bone RANKL is produced mainly by cells of mesenchymal origin. Whether also these cells, besides the osteoclast, are in some way affected by RANKL deficiency is not known. T...

ba0005p395 | Osteoporosis: treatment | ECTS2016

Acute kidney injury after a single intravenous zoledronic acid administration in patients with osteoporosis

Cipriani Cristiana , Clementelli Carolina , Fassino Valeria , Manai Rizieri , Danese Vittoria , Cecchetti Veronica , Ferrone Federica , Pepe Jessica , Minisola Salvatore

Safety data on zoledronic acid (ZA) administration for osteoporosis suggest potential kidney toxicity; indeed, it is not indicated in patients with impaired renal function. Patients’ clinical monitoring usually includes glomerular filtration rate (GFR) evaluation; no study addressed the issue of the early kidney injury. We evaluated the early (within 3 months) effect of iv ZA on renal function defining the potential role of AKI biomarkers in unveiling subtle damage.<p...