Bone Abstracts

Subchondral bone remodelling and osteophyte growth are widely recognised hallmarks of knee osteoarthritis (OA) although their contribution to disease is not fully understood. Murine models, with targeted genetic modifications, have become powerful tools for discovering disease pathophysiology. Our unpublished observations suggest that osteophyte formation is independent of cartilage loss thereby implying potentially independent molecular drivers. We have developed a novel imag...

Aim: Study the features changes of histomorphometric parameters of alveolar ridges in immature rats after thymectomy.Methods: The study was conducted on 120 immature male rats were divided into two groups: 1st group – sham-operated animals, 2nd group – rats with removed of the thymus under mask ether anesthesia (thymectomy). Periods of observation were 7, 15, 30, 90 and 180 days. Rats were euthanized under mask ether anesthesia. For histologica...

Objective: To compare whether interval BMD changes in adolescent females that can be detected using conventional dual energy X-ray absorptiometry (DXA) can also be detected using quantitative peripheral quantitative computerized tomography scans (pQCT) and quantitative ultrasound (QUS)of the os calcis.Methods: Two groups of adolescent females were recruited for assessment of BMD changes over an interval of 22–24 months. These included full time coll...

Background: Prolonged hypothalamic amenorrhoea with anovulation has been associated with hypo-oestrogenism in adolescents and has been shown to be associated with lower bone mineral density (BMD) values.Objective: To determine whether differences in BMD between oligo/amenorrhoeic adolescents at risk of low BMD and normal eumenorrhoeic controls can be detectable by quantitative ultrasound (QUS) of the os calcis.Methods: Adolescents ...

Biographical DetailsDr A Linglart is a Paediatric Endocrinologist working at the Hôpital St Vincent de Paul in Parism, France. She has a special interest in rare diseases....

Muscle mass and strength are known to enhance pediatric gains in bone mineral and bone cross-sectional area, providing a rationale for targeting muscle early in life as a means of improving bone health. We have recently found that the cytokine-like hormone leptin, a well-established adipokine, is abundant in skeletal muscle. Leptin levels normalized for total protein are actually higher in mouse skeletal muscle than in mouse adipose tissue, and studies in human subjects have d...

Biographical DetailsDr HamrickDr Hamrick is Regent’s Professor in the Department of Cellular Biology & Anatomy at the Medical College of Georgia, Augusta University (formerly Georgia Health Sciences University), Augusta, Georgia, USA. He received his PhD in Cellular & Integrative Biology from Northwestern University and completed postdo...

Objectives: The aim of this study was establish features changes of organometric parameters of bones in mature male rats after a 60-day inhalation seed toluene.Materials and methods: For the experiment were selected 60 mature male rats were divided into two groups: 1st – intact rats, 2nd group – the rats that every day for 2 months to device for inhalation agents received a one-time inhalation of toluene exposure 4 h in 10 maximum permissible c...

The purpose of this research was to study the histological structure of albino rats lower incisors of different ages after thymectomy under the injections of thymogen intrapritoneally.Materials and methods: The experiment was conducted on 360 white rats of three age groups: immature, mature, and senile period.Results: Injection of thymogen on the traditional pattern immature rats was accompanied by an increase in the width of the p...

Introduction: The purpose of this research was to study the histological structure of albino rats lower incisors of different ages after thymectomy.Materials and methods: The experiment was conducted on 360 white rats of three age groups: immature, mature and senile period. All animals were subjected to surgical thymectomy.Results: In immature rats after thymectomy predentin layer width was less than the control from 30 till 180 da...